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Hasil Pencarian

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Dadan Rohdiana
"Gangguan pendengaran sensorineural merupakan salah satu komplikasi pada otitis media supuratif kronik (OMSK). Kelainan ini bisa bersifat sementara atau permanen dan dipengaruhi oleh banyak faktor. Pemeriksaan audiometri konvensional, masking dan tes Sensorinural Acuity Level (SAL) dapat menilai seberapa besar kejadian ini. Penelitian ini bertujuan untuk mengetahui prevalensi gangguan pendengaran sensorineural pada OMSK dan faktor yang berhubungan.
Penelitian ini merupakan penelitian potong lintang bersifat deskriptif analitik yang dilakukan di Poli THT RSUPN dr. Cipto Mangunkusumo periode Januari-Mei 2015 melibatkan 73 telinga OMSK. Gangguan pendengaran sensorineural pada OMSK didapatkan sebanyak 24,7% dan umumnya terjadi pada frekuensi tinggi. Tipe OMSK, durasi penyakit, dan tipe perforasi dapat memengaruhi gangguan pendengaran sensorineural dan secara statistik bermakna. Gangguan pendengaran sensorineural terjadi pada OMSK dan pemeriksaan audiometri yang benar dapat menentukan kejadian ini. Tipe OMSK, durasi penyakit, dan tipe perforasi memengaruhi kejadian gangguan pendengaran sensorineural pada OMSK.

Sensorineural hearing loss is one of the complications of chronic suppurative otitis media (CSOM). This order can be temporary or permanent and influenced by many factors. Conventional audiometry, masking, and Sensorineural Acuty Level (SAL) test can diagnose this incident. This study aims to determine the prevalence sensorineural hearing loss in chronic suppurative otitis media and related factors.
This study was a cross sectional descriptif analytic which done at ENT Department Cipto Mangunkusumo Hospital periode January to May 2015 involving 73 ears of CSOM. The prevalence of sensorineural hearing loss in CSOM is about 24,7% and generally occurs at high frequency. Type of CSOM, duration of disease, and type of perforation may affect sensorineural hearing loss and statistically significant. Sensorineural hearing loss accurs in CSOM and audiometry examination can determine this condition. Type of CSOM, duration of disease, and type of perforation influence the incidence of sensorineural hearing loss in CSOM.
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Jakarta: Fakultas Kedokteran Universitas Indonesia, 2015
T-Pdf
UI - Tesis Membership  Universitas Indonesia Library
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Anggina Diksita Pamasya
"[ABSTRAK
Gangguan pendengaran akibat stroke yang terjadi pada jalur auditorik merupakan aspek yang sedikit sekali dieksplorasi pada pasien pasca stroke dan berpotensi menimbulkan dampak pada fungsi dan kualitas hidup. Pendengaran memfasilitasi komunikasi verbal sehingga hal ini penting untuk memberikan penatalaksanaan yang sesuai dan maksimal. Untuk mengukur proporsi gangguan pendengaran dan gangguan komunikasi verbal pada pasien pasca stroke dapat dilakukan pemeriksaan audiometri nada murni, audiometri tutur, dan audiometri tutur dalam bising untuk mengkaji bagaimana gangguan pendengaran berkorelasi dengan karakteristik demografik dan karakteristik klinis serta faktor yang mempengaruhi. Penelitian potong lintang ini dilakukan di RSUPN dr. Cipto Mangunkusumo Jakarta pada bulan November 2014 sampai Mei 2015, melibatkan 40 subyek pasien pasca stroke otak (eksklusi afasia, gangguan fungsi luhur dan gangguan kognitif) yang terdiagnosis dari pencitraan tomografi komputer kepala. Sebanyak 40% mengalami gangguan pendengaran sensorineural (ringan 37,5% dan sedang 20%). Gangguan pendengaran sentral didapatkan 12,5 dan campuran (sensorineural dan sentral) sebanyak17,5%. Didapatkan gangguan komunikasi verbal dalam suasana tenang dan bising 12,% sedangkan gangguan dalam suasana bising sebanyak 32,5%. Berdasarkan nilai odds rasio didapatkan kecenderungan faktor risiko usia lebih dari 60 tahun, letak lesi kortikal dan atau subkortikal serta vaskularisasi lesi dapat mempengaruhi gangguan pendengaran dengan atau tanpa disertai gangguan komunikasi dan secara statistik bermakna.

ABSTRACT
Hearing loss due to stroke which disturb the auditoric path is less known, and may potentially effect the function and quality of life. Hearing facilitates a good speech hence it is important to give appropriate and optimal treatment. To measure the proportion of hearing loss and speech disorder in post stoke patient, we did pure tone audiometry, speech audiometry, and word in noise and to analyze how it could correlate with demographic, clinical characteristic and other factors. This cross sectional study was conducted in Cipto Mangunkusumo hospital Jakarta which started from November 2014 to May 2015, involving 40 samples after stroke patient (with the exclusion of aphasia and cognitive disorder) which were diagnosed with brain CT scan. Fourty percents patients had sensoryneural hearing loss (mild 37,5% and moderate 20%,). Central Hearing loss was found in 12.5% patients and mixed (sensorineural and sentral) hearing loss was found in 17.5%. Speech disorder in quite and noise background was found in 12.5% patients and disorder in noise background was found in 32.5% patients. Based on the odds ratio it is found that age older than 60 year old, cortical and or subcortical lesion, and vascularization of the lesion is the risk factor that can influence hearing disorder with or without speech disorder and it is statistically significance.;Hearing loss due to stroke which disturb the auditoric path is less known, and may potentially effect the function and quality of life. Hearing facilitates a good speech hence it is important to give appropriate and optimal treatment. To measure the proportion of hearing loss and speech disorder in post stoke patient, we did pure tone audiometry, speech audiometry, and word in noise and to analyze how it could correlate with demographic, clinical characteristic and other factors. This cross sectional study was conducted in Cipto Mangunkusumo hospital Jakarta which started from November 2014 to May 2015, involving 40 samples after stroke patient (with the exclusion of aphasia and cognitive disorder) which were diagnosed with brain CT scan. Fourty percents patients had sensoryneural hearing loss (mild 37,5% and moderate 20%,). Central Hearing loss was found in 12.5% patients and mixed (sensorineural and sentral) hearing loss was found in 17.5%. Speech disorder in quite and noise background was found in 12.5% patients and disorder in noise background was found in 32.5% patients. Based on the odds ratio it is found that age older than 60 year old, cortical and or subcortical lesion, and vascularization of the lesion is the risk factor that can influence hearing disorder with or without speech disorder and it is statistically significance., Hearing loss due to stroke which disturb the auditoric path is less known, and may potentially effect the function and quality of life. Hearing facilitates a good speech hence it is important to give appropriate and optimal treatment. To measure the proportion of hearing loss and speech disorder in post stoke patient, we did pure tone audiometry, speech audiometry, and word in noise and to analyze how it could correlate with demographic, clinical characteristic and other factors. This cross sectional study was conducted in Cipto Mangunkusumo hospital Jakarta which started from November 2014 to May 2015, involving 40 samples after stroke patient (with the exclusion of aphasia and cognitive disorder) which were diagnosed with brain CT scan. Fourty percents patients had sensoryneural hearing loss (mild 37,5% and moderate 20%,). Central Hearing loss was found in 12.5% patients and mixed (sensorineural and sentral) hearing loss was found in 17.5%. Speech disorder in quite and noise background was found in 12.5% patients and disorder in noise background was found in 32.5% patients. Based on the odds ratio it is found that age older than 60 year old, cortical and or subcortical lesion, and vascularization of the lesion is the risk factor that can influence hearing disorder with or without speech disorder and it is statistically significance.]"
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2015
T58644
UI - Tesis Membership  Universitas Indonesia Library
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Raden Ayu Anatriera
"Latar belakang: Teknik rekayasa jaringan kartilago memiliki potensi besar dalam rekonstruksi trakea. Scaffold sebagai salah satu unsur utama rekayasa jaringan berperan dalam menyediakan lingkungan tempat sel punca bertumbuh. Komposit campuran kolagen tipe I dan II dipadukan dengan kondroitin serta teknik crosslinkingkedua bahan scaffolddengan genipin dilakukan untuk meningkatkan sifat mekanis. Tujuan: Mengetahui karakteristik morfologi permukaan, biomekanik, dan sitotoksisitas scaffold komposit kolagen-kondroitin crosslink secara in vitro. Metode: Scaffold campuran komposit kolagen tipe I dan tipe II perbandingan 3:1 kemudian dicampur kondroitin dengan rasio 1:3 dibagi dalam kelompok dengan dan tanpa genipin. Hasil: Gambaran morfologi permukaan scaffold dengan genipin menunjukkan matriks padat homogen sedangkan matriks scaffoldtanpa genipin berupa fibriler longgar. Hasil sitotoksisitas menunjukkan tidak terdapat perbedaan bermakna secara statistik (p=0,09) pada rerata jumlah sel pada scaffolddengan dan tanpa genipin serta kontrol. Kesimpulan: Scaffold kolagen kondroitin dengan genipin memiliki mikrostruktur yang lebih padat dan ukuran pori kecil. Genipin dapat menunjang mikrostruktur pada scaffold berbahan kolagen-kondroitin. Scaffold kolagen kondroitin dengan dan tanpa genipin tidak bersifat toksik terhadap sel punca mesenkimal.

Background: Tissue engineering for trachea reconstruction nowadays plays an important rule to endow an ideal biomaterial for cartilage, the tracheal backbone. In this study, the biocomposit of collagen type I, type II, and chondroitin sulfate was investigated. Chemical crosslinking using genipin to improve its properties was then studied. Objective: To find out the surface morphology characteristics, biomechanics, and cytotoxicity of crosslinked scaffold collagen-chondroitin composites in vitro. Method: hydrogel mixture of collagen type I and type II at the ratio of 3:1, was then added into chondroitin sulfate (1 in 3), crosslinked using genipin. Sample without genipin was compared. Results: Crosslinked collagen chondroitin biocomposit showed a homogeneous shape while the non-crosslinked biocomposit had rough surface and bigger pore size. Both types of biocomposits were biocompatible, showed no toxic effects, as the ATP counts had no different compared to the cell colony only. Conclusion: collagen chondroitin crosslinked with genipin had generated a fine microstructure scaffold with smaller pore size, while no exhibition of residual toxicity."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2019
T59148
UI - Tesis Membership  Universitas Indonesia Library