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Dian Cahyanti
Korelasi Ekspresi Rad51 dengan Penyusutan Massa Tumor Karsinoma Nasofaring = Rad51 Expression Correlation with the Tumor Shrinkage of Nasopharyngeal Carcinoma
"Latar Belakang: Salah satu masalah dalam tatalaksana karsinoma nasofaring (KNF) adalah masih tingginya angka rekurensi pascaterapi. Hingga saat ini, biomarker yang digunakan di klinik untuk mengevaluasi hasil terapi definitif pada KNF adalah melalui CT scan nasofaring. Overekspresi Rad51 berhubungan dengan peningkatan resistensi sel tumor terhadap radiasi dan kemoterapi. Oleh karena rekurensi pascaterapi berhubungan dengan resistensi sel-sel tumornya, maka penelitian ini dilakukan dengan tujuan untuk menilai korelasi antara ekspresi Rad51 pada biopsi nasofaring sebelum terapi dengan penyusutan massa tumor pascaterapi yang diukur dengan metode unidimensional.
Bahan dan Metode: Studi potong lintang dilakukan pada 15 kasus KNF. Ekspresi Rad51 dinilai dari biopsi nasofaring sebelum terapi. Evaluasi hasil terapi dilihat dari penyusutan massa tumor, berdasarkan CT scan nasofaring sebelum dan setelah terapi definitif. Cara yang digunakan untuk mengukur penyusutan massa tumor adalah dengan mengukur diameter terpanjang (unidimensional).
Hasil: Ekspresi dari pewarnaan Rad51 yang dinilai berdasarkan skor-H menunjukkan hubungan bermakna dan korelasi yang kuat dengan penyusutan massa tumor. Diperoleh nilai p = 0,005 dan koefisien korelasi r = - 0,64.
Kesimpulan: Ekspresi Rad51 memiliki korelasi negatif dengan penyusutan massa tumor karsinoma nasofaring.
Background: The remain challenging problem in the management of nasopharyngeal carcinoma (NPC) is its higher rate of recurrency. Untill now, CT scan is the most common use biomarker to evaluate the treatment response after the definitive therapy. There’s a significance association between Rad51 overexpression and the increasing of resistancy to irradiation and chemotherapy in tumor cells and the resistancy of tumor cells correlates to its recurrency after therapy. Therefore, this study was conducted to evaluate the correlation between Rad51 expression level and the tumor’s shrinkage with unidimensional measurement. Material and
Methods: Fifteen cases of NPC were analyzed by a cross-sectional study. The expression of Rad51 were taken from the pretreatment of nasopharyngeal biopsy. The treatment response was evaluated from the nasopharyngeal CT scan, before and after definitive therapy, using the unidimensional measurement based on the change in sum longest diameter.
Result: The expression of Rad51 immunostaining assessed by the H-score were strongly correlate with the regression of the tumor mass which represent the treatment response. The p value is 0,005 and the correlation’s coefficient is -0,64.
Conclusion: There is significant correlation with negative magnitude between the expression of Rad51 with the shrinkage of tumor mass in nasopharyngeal carcinoma."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2014
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UI - Tugas Akhir  Universitas Indonesia Library
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Sugianto Santoso
Beda rerata ukuran beberapa organ telinga dalam balita tuli sensorineural kongenital dengan balita normal berdasarkan hrct tulang temporal = The mean size different of several inner ear organ on congenital hearing loss toddler with normal toddler based on temporal bone hrct
"Latar Belakang : Pemeriksaan HRCT tulang temporal pada pasien dengan tuli sensorienural kongenital / congenital sensorineural hearing loss (CSNHL) mengidentifikasi malformasi telinga dalam sebesar 25%, sementara itu organ telinga dalam terlihat normal secara kualitatif pada 75% pasien. Malformasi berat dari struktur telinga dalam mudah terdiagnosis melalui inspeksi kualitatif, sementara itu displasia yang kurang berat atau malformasi ringan luput dari pemeriksaan kualitatif.
Tujuan : Mempertajam evaluasi diagnosis malformasi telinga dalam menggunakan CT scan untuk diagnosis CSNHL sebagai kandidat implan koklea. Desain penelitian : retrospektif potong lintang.
Metode : Pengukuran koklea, bony island kanalis semisirkularis lateral (KSS lateral), kanalis akustikus internus (KAI) dan bone cochlear nerve canal (BCNC) dibuat secara 3D MPR HRCT pada 15 pasien dengan normal pendengaran dan 15 pasien CSNHL yang secara kualitatif normal pada CT scan tulang temporal. Tes T tidak berpasangan dilakukan untuk membandingkan pengukuran kedua kelompok.
Hasil : Terdapat pengecilan signifikan diameter kraniokaudal KAI (p<0.05) pada balita CSNHL dibandingkan normal, sedangkan tidak terdapat perbedaan signifikan pada ukuran koklea, bony island KSS lateral, BCNC dan diameter transversal KAI serta rata-ratanya antara kedua kelompok.
Kesimpulan : Kecilnya diameter kraniokaudal KAI mengesankan penggunaan HRCT tulang temporal dapat digunakan untuk mempertajam diagnosis pasien CSNHL serta memprediksi displasia integritas nervus kokelaris yang mempengaruhi prognosis implan koklea.
Background : Temporal bone HRCT examination on CSNHL patients are identifies with inner ear malformation in approximately 25%, whereas the inner ear is grossly normal to qualitative examination in the remaining 75% of the patients. Severe malformation of the inner ear structure are easy to diagnose via qualitative inspection, while less severe dysplasia or mild malformation are missed by simple qualitative inspection.
Objective : Sharpen diagnostic evaluation for the diagnosis of the inner ear malformation of CSNHL as cochlear implant candidates.
Study design : retrospective cross sectional Methods : Measurements of the cochlea, bony island lateral semisircular canal (LSCC), internal auditory canal (IAC), and bone cochlear nerve canal (BCNC) were made on 3D MPR HRCT on 15 patients with normal hearing and 15 patients CSNHL qualitatively normal on temporal bone CT scan. Independent t-test was performed to compare the measurements of the two groups.
Results : There is significant diminution on craniocaudal IAC diameter (p<0.05) on CSNHL toddler compare to normal, whereas there is no significant different in the measurements of the cochlea, bony island LSCC, BCNC and tranverse diameter of the IAC as well as the average between the two groups.
Conclusions : Narrowing of the IAC craniocaudal diameter impress that temporal bone HRCT can be used to refine the diagnosis CSNHL patients and predict dysplasia of the cochlear nerve integrity affecting prognosis for cochlear implant."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2014
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UI - Tugas Akhir  Universitas Indonesia Library
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Siagian, Minarma
Reliabilitas submentovertex dalam pengukuran mandibula berdasarkan perbandingan ukuran radiogram terhadap ukuran tulang asli studi kuantitatif pada tulang tengkorak kering manusia = Reliability of submentovertex image compared to direct mandible measurements study in dried human skull
"[ABSTRAK
Berbagai macam panduan rekonstruksi mandibula telah dikembangkan untuk mengurangi angka komplikasi Golden standard panduan rekonstruksi mandibula saat ini adalah pemeriksaan radiologi 3 dimensi yang memberikan ukuran sesuai dengan ukuran aslinya namun proyeksi submentovertex memiliki kelebihan berupa efektifitas dalam menampilkan keseluruhan struktur kraniomaksilofasial dalam satu film sehingga menjadi lebih singkat pengerjaannya dan ekonomis Tujuan Penelitian ini bertujuan melihat reliabilitas ronsen submentovertex dengan membandingkan hasil pengukuran menggunakan kaliper mitutuyo langsung pada tulang mandibula dengan hasil pengukuran mandibula menggunakan PACS pada ronsen submentovertex Material dan metodePenelitian ini menggunakan 50 tulang mandibula yang dipasangkan dengan tulang kranium dan tulang kalvaria Penanda logam bentuk bulat diameter 1mm dipasang pada titik Pogonion Gonion kiri dan kanan Lateral Procesus Condylaris kiri dan kanan Parameter yang diukur adalah jarak titik Gonion kiri ke Gonion kanan jarak titik Lateral Procesus Condylaris kiri ke Lateral Procesus Condylaris kiri besar sudut yang dibentuk oleh titik Gonion kanan Pogonion Gonion kiri dan besar sudut yang dibentuk oleh titik Lateral Procesus Condylaris kiri Pogonion Lateral Procesus Condylaris kanan Tulang tengkorak kemudian dironsen submentovertex Pengukuran manual dilakukan menggunakan kaliper mitutuyo langsung pada tulang mandibula sedangkan pengukuran ronsen Submentovertex menggunakan program Picture Archiving Computerised System Pengukuran dilakukan tiga kali dengan jarak waktu pengukuran 24 jam oleh satu orang Hasil pengukuran manual dan submentovertex kemudian dibandingkan dengan menggunakan uji statistik t berpasangan dengan tingkat ketelitian 95 p0 05 yang berarti hasil pengukuran manual dan submentovertex berbeda bermakna Kesimpulan Ukuran tulang mandibula hasil pengukuran menggunakan kaliper dengan Submentovertex berbeda bermakna Hasil pengukuran angular dan linear pada submentovertex lebih besar daripada hasil pengukuran manual pada tulang mandibula ABSTRACT IntroductionAblative tumor surgery cause discontinuity of the mandible Various guidances had been introduced in mandible reconstruction to reduce complication rate Three dimensional computed assisted is the golden standard Plain radiology such as submentovertex has some advantages cost efective and low radiation dose Every guidance must be reliable Objective The purpose of this study is to examine the reliabity of submentovertex image compared to golden standard of direct mandible measurement using caliper Material and MethodThe sample of this study were 50 dried human mandibles paired with os calvaria and os cranium 1mm diameter of metal marker were placed in Pogonion left and right Gonion right and left Lateral Procesus Condylaris Linear measurements were left Gonion ndash right Gonion right Lateral Procesus Condylaris ndash left Lateral Procesus Condylaris Angular measurements were right Gonion ndash Pogonion ndash left Gonion and right Lateral Procesus Condylaris ndash Pogonion ndash left Lateral Procesus Condylaris Direct measurement on the mandible was done by using caliper Mitutuyo and Picture Archiving Computerised System for measuring the mandible on submentovertex image One observer measured the mandible three times 24 hours range of time for each measurements The result between direct measurement and submentovertex image were compared and tested using paired t test p0 05 Conclusion There were significant difference on both angular and linear measurement of the mandible between direct caliper measurement and Picture Archiving Computerised System for Submentovertex image ;IntroductionAblative tumor surgery cause discontinuity of the mandible Various guidances had been introduced in mandible reconstruction to reduce complication rate Three dimensional computed assisted is the golden standard Plain radiology such as submentovertex has some advantages cost efective and low radiation dose Every guidance must be reliable Objective The purpose of this study is to examine the reliabity of submentovertex image compared to golden standard of direct mandible measurement using caliper Material and MethodThe sample of this study were 50 dried human mandibles paired with os calvaria and os cranium 1mm diameter of metal marker were placed in Pogonion left and right Gonion right and left Lateral Procesus Condylaris Linear measurements were left Gonion ndash right Gonion right Lateral Procesus Condylaris ndash left Lateral Procesus Condylaris Angular measurements were right Gonion ndash Pogonion ndash left Gonion and right Lateral Procesus Condylaris ndash Pogonion ndash left Lateral Procesus Condylaris Direct measurement on the mandible was done by using caliper Mitutuyo and Picture Archiving Computerised System for measuring the mandible on submentovertex image One observer measured the mandible three times 24 hours range of time for each measurements The result between direct measurement and submentovertex image were compared and tested using paired t test p0 05 Conclusion There were significant difference on both angular and linear measurement of the mandible between direct caliper measurement and Picture Archiving Computerised System for Submentovertex image , IntroductionAblative tumor surgery cause discontinuity of the mandible Various guidances had been introduced in mandible reconstruction to reduce complication rate Three dimensional computed assisted is the golden standard Plain radiology such as submentovertex has some advantages cost efective and low radiation dose Every guidance must be reliable Objective The purpose of this study is to examine the reliabity of submentovertex image compared to golden standard of direct mandible measurement using caliper Material and MethodThe sample of this study were 50 dried human mandibles paired with os calvaria and os cranium 1mm diameter of metal marker were placed in Pogonion left and right Gonion right and left Lateral Procesus Condylaris Linear measurements were left Gonion ndash right Gonion right Lateral Procesus Condylaris ndash left Lateral Procesus Condylaris Angular measurements were right Gonion ndash Pogonion ndash left Gonion and right Lateral Procesus Condylaris ndash Pogonion ndash left Lateral Procesus Condylaris Direct measurement on the mandible was done by using caliper Mitutuyo and Picture Archiving Computerised System for measuring the mandible on submentovertex image One observer measured the mandible three times 24 hours range of time for each measurements The result between direct measurement and submentovertex image were compared and tested using paired t test p0 05 Conclusion There were significant difference on both angular and linear measurement of the mandible between direct caliper measurement and Picture Archiving Computerised System for Submentovertex image ]"
Fakultas Kedokteran Gigi Universitas Indonesia, 2015
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UI - Tugas Akhir  Universitas Indonesia Library
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Dessy Wimelda
Proporsi defleksi kanalis fallopii segmen mastoid menggunakan high-resolution multidetector computed tomography pada tulang temporal normal = The proportion of mastoid segment of fallopian canal deflection using high-resolution multidetector with normal temporal bone
"Tujuan: Penelitian ini dilakukan untuk mendapatkan data profil kanalis fallopii segmen mastoid dan korda timpani sebelum operasi mastoidektomi untuk mengurangi angka morbiditas cedera kanalis fallopii akibat operasi.
Metode: Pada penelitian retrospektif ini dilakukan rekonstruksi High-Resolution Computed Tomography tulang temporal terhadap 100 tulang temporal normal pada 50 pasien yang menjalani pemeriksaan CT scan kepala dan leher, yang diambil dari raw-data mulai Desember 2012 sampai Februari 2013. Rekonstruksi dilakukan dengan parameter ketebalan irisan 0,6 cm, increment 0,3 cm, Kernel filter Very Sharp (H70s), Window setting Osteo/Mastoid, menggunakan pesawat MDCT Somatom Definition Flash Dual Source 128 slice.
Hasil dan diskusi: Bentuk kanalis fallopii segmen mastoid paling banyak ditemukan tipe lurus sebanyak 75%, defleksi terhadap bidang sagital dan defleksi terhadap bidang horizontal anatomi paling banyak ditemukan tidak terdapat defleksi sebanyak 62% dan 68%. Percabangan korda timpani paling banyak ditemukan intratemporal sebanyak 75%, yang tersering pada 1/3 distal kanalis fallopii segmen mastoid. Sudut korda timpani yang dibentuk korda timpani terhadap kanalis fallopii segmen mastoid paling banyak ditemukan antara 16 sampai 30 derajat sebanyak 37,3%. Ukuran korda timpani yang minimal tervisualisasi adalah 0,04 cm.
Kesimpulan: Proporsi defleksi kanalis fallopii segmen mastoid terhadap bidang sagital dan horizontal adalah tidak terdapat defleksi.
Objectives: This research was conducted to obtain profile data of mastoid segment of fallopian canal and tympanic cord before masteidectomy to reduce the morbidity rate of surgery-related fallopian canal injury.
Material and method: In this retrospective study reconstruction of High Resolution Computed Tomography of the temporal bone in 100 normal temporal bone in 50 patients who underwent a CT scan of the head and neck, were taken from the raw-data from December 2012 to February 2013. Reconstruction is done by parameters slice thickness 0,6 cm, increment 0,3 cm, Kernel filter Very Sharp (H70s), Window setting Osteo/Mastoid,using MDCT Somatom Definition Flash Dual Source 128 slice.
Result: Mastoid segment of fallopian canal commonly found type of straight as much as 75%, deflection of the sagittal plane and the horizontal field of anatomy most commonly found there was no deflection were 62% and 68%, respectively. Branching chordate tympani most commonly found intratemporal as much as 75%, which is common in 1/3 distal of mastoid segmen fallopian canal. The angled formed by chorda tympani and mastoid segment fallopian canal is most prevalent among 16 to 30 degrees as much as 37.3%. The minimum size of the chorda tympani is 0.04 cm.
Conclusion: Proportion of deflection mastoid segment facial canal of the sagittal and horizontal plane there is no deflection."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2013
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UI - Tesis Membership  Universitas Indonesia Library
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Frieska Dwi Nanrasari
Hubungan temuan kecurigaan keterlibatan saraf kranial pada tomografi komputer dengan disfungsi klinis saraf kranial pada karsinoma nasofaring T3-T4 = Association between suspicion cranial nerve involvement in computed tomography findings with clinical cranial nerve dysfunction in nasopharyngeal carcinoma T3- T4 / Frieska Dwi Nanrasari
"ABSTRAK
Penelitian ini bertujuan mengetahui hubungan kecurigaan keterlibatan saraf kranial berdasarkan temuan tomografi komputer dengan disfungsi klinis saraf kranial pada pemeriksaan neurologi penderita karsinoma nasofaring T3-T4. Penelitian ini menggunakan desain potong lintang dengan data sekunder rekam medis dan data tomografi komputer 55 penderita karsinoma nasofaring yang telah terbukti secara histopatologi dan telah dilakukan pemeriksaan neurologi. Hasil penelitian menunjukkan proporsi temuan kecurigaan keterlibatan saraf kranial berdasarkan tomografi komputer lebih tinggi dibandingkan proporsi disfungsi klinis saraf kranial pada pemeriksaan neurologi, sehingga tomografi komputer dapat menjadi acuan deteksi dini serta tatalaksana kemungkinan keterlibatan saraf kranial pada karsinoma nasofaring stadium lanjut yang belum bermanifestasi klinis.
ABSTRACT
This study aims to determined the association between suspicion cranial nerve involvement based on computed tomography findings with clinical cranial nerve dysfunction on neurological examination in nasopharyngeal carcinoma T3-T4. It used cross-sectional design with secondary data medical record and computed tomogtaphy of 55 patients nasopharyngeal carcinoma which has been proven in histopathological biopsy and have performed neurological examination. The results showed the proportion of suspicions findings of cranial nerve involvement in computed tomography is higher than the proportion of clinical cranial nerve dysfunction in neurological examination, based on this result computed tomography could be a reference for early detection and management of the possible cranial nerves involvement at an advanced stage nasopharyngeak carcinoma that has not manifested clinically."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2013
T58731
UI - Tesis Membership  Universitas Indonesia Library
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Chitra Jenni
Pengaruh perluasan pneumatisasi sinus sfenoid ke prosesus klinoid anterior terhadap risiko dehiscence dan protrusio arteri karotis interna dan saraf optik berdasarkan tomografi komputer = The influence of extensive pneumatization of sphenoid sinus to the anterior clinoid process against risk of dehiscence and protrusion of internal carotid artery and optic nerve based on computed tomography
"ABSTRAK
Penelitian ini menilai hubungan dan faktor risiko perluasan pneumatisasi sinus sfenoid ke prosesus klinoid anterior (PKA) terhadap dehiscence dan protrusio AKI dan SO, dua struktur penting yang perlu diwaspadai dalam bedah yang melibatkan sinus sfenoid. Penelitian ini bersifat analitik dengan desain perbandingan potong lintang. Dari hasil penelitian diperoleh perbedaan yang bermakna antara dehiscence AKI, dehiscence SO, protrusio AKI, dan protrusio SO pada kelompok dengan pneumatisasi PKA dan tanpa pneumatisasi PKA (p=0,004, p<0,001, p<0.001, dan p<0,001). Sebagai kesimpulan, perluasan pneumatisasi sinus sfenoid ke PKA berhubungan dan merupakan faktor risiko terhadap dehiscence dan protrusio AKI dan SO di dinding superolateral sinus sfenoid.
ABSTRACT
This study assessed the relationship and risk factors of extensive pneumatization of sphenoid sinus to the anterior clinoid process (ACP) against risk of dehiscence and protrusion of ICA and ON, two important structures that need to watch out for in surgery involving sphenoid sinus. This study is an analytic study using cross-sectional comparative design. There is significant differences between dehiscence of ICA, dehiscence of ON, protrusion of ICA, and protrusion of ON in group with and without ACP pneumatization (p=0.004, p<0.001, p<0.001, and p<0.001). As conclusion, the extensive pneumatization of sphenoid sinus to the ACP is related to and is one of risk factor for dehiscence and protrusion of ICA and ON on superolateral wall of sphenoid sinus."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2013
T58557
UI - Tesis Membership  Universitas Indonesia Library
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Fahriyani
Karakteristik gambaran radiografi toraks pada pasien HIV dengan TB paru berdasarkan diagnosis mikrobiologis dan klinis di RSUPN Cipto Mangunkusumo = Characteristic of chest radiograph findings in HIV patients with lung tuberculosis based on microbiologic and clinical diagnosis in Cipto Mangunkusumo Hospital
"Latar belakang : penegakkan diagnosis TB paru pada pasien HIV dapat dilakukan berdasarkan pemeriksaan mikrobiologis dan klinis. Rekomendasi WHO 2007, memperbolehkan penegakan diagnosis berdasarkan hasil pemeriksaan klinis dengan dan tanpa melalui pemeriksaan mikrobiologis. Penelitian ini bertujuan mendapatkan perbedaan karakteristik gambaran radiografi toraks pasien HIV dengan TB paru yang didiagnosis berdasarkan pemeriksaan mikrobiologis dan klinis.
Metode : Penelitian ini adalah comparative cross sectional study. Subyek penelitian diambil secara consecutive dan dipilih berdasarkan catatan hasil pemeriksaan BTA sputum, kultur, Genexpert®, CD4+, dan radiografi toraks. Subyek penelitian dikelompokkan menjadi mikrobiologis dan klinis. Dilakukan pembacaan ulang radiografi toraks.
Hasil : gambaran radiografi toraks dengan frekuensi terbanyak pada kelompok diagnosis mikrobiologis adalah infiltrat/konsolidasi, fibroinfiltrat, limfadenopati, kavitas dan kalsifikasi. Sisanya efusi pleura, milier, fibrosis, bronkiektasis, pneumotoraks dan normal. Pada kelompok diagnosis klinis, gambaran radiografi toraks dengan frekuensi terbanyak adalah infiltrat/konsolidasi, kavitas, limfadenopati, fibroinfiltrat dan sisanya kalsifikasi, efusi pleura, milier, fibrosis, bronkiektasis, dan normal. Terdapat perbedaan bermakna karakteristik gambaran radiografi toraks fibroinfiltrat pada kelompok diagnosis mikrobiologis dan klinis. Frekuensi fibroinfiltrat terbanyak adalah di kelompok mikrobiologis dengan sebaran lokasi tersering di lapangan atas paru.
Kesimpulan : Terdapat perbedaan bermakna karakteristik gambaran radiografi toraks fibroinfiltrat pada kelompok diagnosis mikrobiologis dan klinis dengan lokasi tersering di lapangan atas paru.
Background : To diagnose Pulmonary Tuberculosis in HIV patient can be done based on microbiology examination and clinically. WHO 2007 recommendation, allowing diagnosis based on clinical examination with and without microbiological examination. This study aims to obtain the different characteristics of chest radiographs of HIV patients with pulmonary TB were diagnosed based on clinical and microbiological examination.
Methods : This study is a comparative cross-sectional study. Subjects were taken consecutively and selected based on the results of sputum smear examination, culture, Genexpert®, CD4+, and chest x-ray. The study subjects were grouped into microbiological and clinical. Then we do expertise review.
Results : The most chest x-ray finding in the microbiological group is infiltrates/ consolidation. Following by fibroinfiltrat, lymphadenopathy, cavities and calcification. The rest are pleural effusion, miliary, fibrosis, bronchiectasis, pneumothorax and normal . In the group of clinical diagnosis, the highest frequency chest x-ray finding is infiltrates/ consolidation. Following by cavities, lymphadenopathy, fibroinfiltrat and the rest are calcification, pleural effusion, miliary, fibrosis, bronchiectasis and normal. There is significant differences of fibroinfiltrat on microbiological and clinical diagnosis groups. The highest frequency of fibroinfiltrat is in the microbiological group with the most common sites in the upper of the lung field.
Conclusions : There is significant differences of fibroinfiltrat on microbiological and clinical diagnosis groups with the most common sites in the upper lung field."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2014
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UI - Tesis Membership  Universitas Indonesia Library
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Rio Kusuma
Perbedaan posisi osikular dan volume telinga tengah pada mikrotia dibandingkan telinga normal berdasarkan HRCT tulang temporal = Differences of ossicular position and middle ear volume in microtia in comparison with normal ear using temporal bone HRCT
"Latar belakang dan tujuan: Mikrotia adalah malformasi kongenital yang seringkali disertai atresia auris dan kelainan telinga tengah. Kelainan ini dikoreksi dengan kanaloplasti dan timpanoplasti. Titik dan arah pengeboran kanaloplasti merupakan hal yang penting. Saat ini belum terdapat panduan yang objektif dalam menentukan arah pengeboran. Volume telinga tengah, berperan penting dalam penentuan keluaran hasil pembedahan, namun saat ini belum pernah dikaitkan dengan sudut α dan β. Penelitian ini bertujuan menilai hubungan sudut α dan β dengan volume telinga tengah tmikrotia dan telinga normal menggunakan HRCT temporal.
Metode: Menggunakan desain potong lintang. Subjek penelitian merupakan data sekunder HRCT tulang temporal, kemudian dilakukan pengukuran sudut α dan β dan volume telinga tengah.
Hasil: Subjek penelitian berjumlah 34 sampel. Terdapat perbedaan bermakna sudut α dan sudut β telinga mikrotia dibandingkan telinga normal, dengan nilai p<0.001. Rerata volume telinga tengah mikrotia 0.36 cc, normal 0.67 cc. Tidak didapatkan korelasi volume telinga tengah dengan sudut α dan β, pada mikrotia maupun telinga normal. Nilai cut-off sudut α sebesar 15.40, sensitivitas 85.3% dan spesifisitas 82.4%. nilai cut-off sudut β sebesar 270, sensitivitas 73.5% dan spesifisitas 76.5%.
Kesimpulan: Perbedaan posisi osikular dengan nilai cut-off yang didapat untuk sudut α dan β dapat menjadi acuan dasar pada operasi kanaloplasti.
Background and Objectives: Microtia is a congenital malformation with associated auricle atresia and middle ear abnormality, which is treated by canaloplasty and tympanoplasty. Drilling starting point and the direction in canaloplasty operation are no doubt very important things. Nowadays, guideline for determining the drilling direction has not been yet established. Middle ear volume which is one of important variable in determining operation outcome, has not been associated with α and β angle. This study intended to evaluate α and β angle and its relationship with middle ear volume using (HRCT) temporal bone.
Method: Cross-sectional design were used. Data from previous HRCT examination were used to measured α and β angle and middle ear volume.
Results: From 34 subjects, there were significant differences of α and β angle in microtic ear compared to normal ear, with p < 0.001. Middle ear volume average for microtic ear and normal ear were 0.36 cc and 0.67 cc, respectively. No significant correlation between middle ear volume and α and β angle. Cut-off value for α angle is 15.40 with sensitivity 85.3% and specificity 82.4%. Cut-off value for β angle is 270 with sensitivity 73.5% and specificity 76.5%.
Conclusion: Differences in ossicular position with obtained cut-off value for α and β angle could become a base guidance in canaloplasty operation."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2015
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UI - Tesis Membership  Universitas Indonesia Library
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Asih Maratani
Korelasi ukuran bidimensional dengan volume tumor primer karsinoma nasofaring menggunakan computed tomography scan = Correlation between bidimensional and volume measurement of the primary tumour of nasopharyngeal carcinoma using computed tomography scan
"Latar belakang: Pengukuran tumor primer karsinoma nasofaring (KNF) belum rutin dikerjakan karena bentuknya yang ireguler dengan infiltrasi yang ekstensif pada jaringan sekitarnya. Pengukuran volume memiliki akurasi tinggi namun sulit dilakukan dan memerlukan waktu lama. Lebih lanjut, belum ada penelitian yang membandingkan antara teknik pengukuran bidimensional dengan volume tumor primer KNF di Indonesia.
Tujuan: Mendapatkan nilai korelasi ukuran bidimensional terhadap volume tumor primer KNF pada pemeriksaan Computed Tomography (CT) scan.
Metode: Penelitian ini menggunakan desain potong lintang dengan metode simple random sampling. Subjek penelitian berjumlah 50 pasien KNF yang menjalani pemeriksaan CT scan nasofaring di Departemen Radiologi FKUI/RSUPN CM. Penelitian dilakukan sejak Juni hingga September 2015. Pengukuran volume tumor primer nasofaring pada PACS INFINITT dilanjutkan dengan pengukuran bidimensional satu minggu kemudian.
Hasil: Uji korelasi Spearman antara ukuran bidimensional dengan volume KNF memperlihatkan nilai p<0,001 dan r=0,9, dengan formula regresi volume tumor primer = - 11,38 + (1,97 x ukuran bidimensional).
Kesimpulan: Terdapat korelasi positif sangat kuat antara ukuran bidimensional dengan volume KNF.
Background: Primary tumour measurement of the nasopharyngeal carcinoma (NPC) has not been routinely performed because of its irregular shape and extensive infiltration to adjacent structures. Measuring the volume is highly accurate yet highly difficult and time-consuming. Moreover, there has not been comparison study between the bidimensional and volume measurement of the primary tumour of NPC done in Indonesia before.
Purpose: To obtain the correlation value of the bidimensional measurement to the volume of the primary tumour of NPC using the CT scan.
Method: This study used a cross-sectional design. Fifty subjects were chosen using simple random sampling from NPC patients that underwent nasopharyngeal CT scan at the Radiology Department of the Indonesia University's Faculty of Medicine/Cipto Mangunkusumo Hospital. This study was done from June until September 2015. NPC volume measurement was performed using PACS INFINITT, followed by the bidimensional measurement one week after.
Results: Spearman correlation test between bidimensional and volume measurement of NPC shows p value<0.001 and strength of correlation (r) = 0.9, with regression formula of the primary tumour volume = - 11.38 + (1.97 x bidimensional measurement).
Conclusion: There is a very strong positive correlation between bidimensional and volume measurement of NPC. "
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2015
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UI - Tugas Akhir  Universitas Indonesia Library
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Asih Maratani
Korelasi ukuran bidimensional dengan volume tumor primer karsinoma nasofaring menggunakan computed tomography scan = Correlation between bidimensional measurement and primary tumour volume in nasopharyngeal carcinoma by computed tomography examination
"Latar belakang: Pengukuran tumor primer karsinoma nasofaring KNF belum rutin dikerjakan karena bentuknya yang ireguler dengan infiltrasi yang ekstensif pada jaringan sekitarnya Pengukuran volume memiliki akurasi tinggi namun sulit dilakukan dan memerlukan waktu lama Lebih lanjut belum ada penelitian yang membandingkan antara teknik pengukuran bidimensional dengan volume tumor primer KNF di Indonesia
Tujuan: Mendapatkan nilai korelasi ukuran bidimensional terhadap volume tumor primer KNF pada pemeriksaan Computed Tomography CT scan.
Metode: Penelitian ini menggunakan desain potong lintang dengan metode simple random sampling Subjek penelitian berjumlah 50 pasien KNF yang menjalani pemeriksaan CT scan nasofaring di Departemen Radiologi FKUI RSUPN CM Penelitian dilakukan sejak Juni hingga September 2015 Pengukuran volume tumor primer nasofaring pada PACS INFINITT dilanjutkan dengan pengukuran bidimensional satu minggu kemudian
Hasil: Uji korelasi Spearman antara ukuran bidimensional dengan volume KNF memperlihatkan nilai p
Background: Primary tumour measurement of the nasopharyngeal carcinoma NPC has not been routinely performed because of its irregular shape and extensive infiltration to adjacent structures Measuring the volume is highly accurate yet highly difficult and time consuming Moreover there has not been comparison study between the bidimensional and volume measurement of the primary tumour of NPC done in Indonesia before
Purpose: To obtain the correlation value of the bidimensional measurement to the volume of the primary tumour of NPC using the CT scan
Method: This study used a cross sectional design Fifty subjects were chosen using simple random sampling from NPC patients that underwent nasopharyngeal CT scan at the Radiology Department of the Indonesia University's Faculty of Medicine Cipto Mangunkusumo Hospital This study was done from June until September 2015 NPC volume measurement was performed using PACS INFINITT followed by the bidimensional measurement one week after
Results: Spearman correlation test between bidimensional and volume measurement of NPC shows p value"
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2016
SP-PDF
UI - Tugas Akhir  Universitas Indonesia Library
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