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"Telah dilakukan penelitian secara before and after terhadap pasien HD kronik antara bulan Mei 1997 - Juli 1997 di Subbagian Ginjal Hipertensi, SMF llmu Penyakit Dalam FKUI / RSUPN Dr.Cipto Mangunkusumo. Penelitian ini bertujuan untuk mengetahui perubahan sistem koagulasi akibat hemodialisis. Setelah melalui proses eksklusi terhadap faktor-faktor yang dapat mempengaruhi sistem koagulasi, diteliti 30 subyek yang terdiri dari 20 laki-laki (66,6%) dan 10 perempuan (33,3%). Umur termuda 13 tahun dan tertua 71 tahun dengan rerata 45,5; 13,5 tahun.

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A before and after study has been conducted on chronic HD patients between May 1997 - July 1997 in the Hypertension Kidney Subdivision, SMF llmu Internal Medicine FKUI / Dr.Cipto Mangunkusumo Hospital. This study aims to determine the changes in the coagulation system as a result of hemodialysis. After going through the process of exclusion of factors that can affect the coagulation system, 30 subjects consisting of 20 male (66.6%) and 10 female (33.3%). The youngest age is 13 years old and the oldest is 71 years old with an average of 45.5; 13.5 years."

"LATAR BELAKANG: Hipertensi merupakan salah satu masalah kesehatan yang turut berperan dalam peningkatan angka morbiditas dan mortalitas stroke, gagal jantung dan gagal ginjal. Morbiditas dan mortalitas hipertensi meningkat dengan makin banyaknya faktor risiko yang dimiliki, makin tinggi tekanan darah dan makin lama seseorang menderita hipertensi. Sampai saat ini mekanisme pasti terjadinya hipertensi belum jelas. Belakangan ini disfungsi endotel juga dikaitkan dengan hipertensi. Tujuan penelitian ini untuk mendapatkan gambaran kadar sVCAM-1 dan MAU, membuktikan adanya hubungan antara kadar sVCAM-1 dan MAU, menganalisis pengaruh usia, gender, obesitas, terkendali tidaknya hipertensi, lama sakit dan kadar kolesterol terhadap kadar sVCAM-1 dan MAU pada penderita hipertensi primer.BAHAN DAN METOPE: Penelitian ini menggunakan 65 subyek non diabetik dengan kadar hs-CRP < 5 mgIL dan protein win < 3+. Dilakukan pemeriksaan kadar sVCAM-1, K-LDL, albumin dan kreatinin urin terhadap subyek dengan protein win negatif atau trace, sedangkan subyek dengan protein urin 1+ atau 2+ hanya dilakukan pemeriksaan kadar sVCAM-1 dan K LDL. Penetapan kadar sVCAM-1 berdasarkan prinsip quantitative sandwich enzyme immunoassay, penetapan kadar K-LDL berdasarkan prinsip enzimatik homogen, penetapan kadar albumin urin berdasarkan prinsip imunoturbidimetri, penetapan kreatinin urin berdasarkan metode kinetik Jaffe dan MAU dinyatakan dengan rasio albumin 1 kreatinin urin.HASIL: Hasil penelitian menunjukkan proporsi kadar sVCAM-1 tinggi sebesar 81,5 % dan MAU 27,7 %. Kadar sVCAM-1 tinggi dan MAU lebih banyak dijumpai pada subyek tua, lelaki, hipertensi tak terkendali, lama sakit > 10 tahun dan obese. Dari hasil analisis multivariat derigail regresi rr ultipel, Adak didapatkan korelasi -yang bermakna antara kadar sVCAM-1 dengangender dan lama sakit namun didapatkan korelasi yang bermakna antara kadar sVCAM-1 dengan usia, MAP dan K-LDL. Hubungan tersebut dapat digambarkan melalui suatu persamaan yaitu kadar sVCAM-1 = 175 + 9,7 x usia (tahun) + 5,9 x MAP (mmHg) -- 2,9 x kadar K-LDL (rngldL) dengan nilai R2 adjusted sebesar 23,1 %. Tidak didapatkan korelasi yang bermakna antara MAU dengan usia, gender, MAP. 1MT, lama sakit dan K-LDL.Tidak didapatkan korelasi yang bermakna antara kadar sVCAM-1 dan rasio A 1 K.KESIMPULAN: Berdasarkan hasil penelitian ini didapatkan proporsi kadar sVCAM-1 tinggi 81,5 % dan MAU 27,7 %. Hal ini menunjukkan bahwa pada penderita hipertensi primer telah terjadi disfungsi endotel. Dari analisis multivariat menunjukkan kadar sVCAM-1 berkorelasi dengan usia, MAP dan K-LDL, sedangkan MAU tidak berkorelasi dengan variabel tersebut. Kadar sVCAM-1 tidak berkorelasi dengan MAU.

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Hypertension is a health problem which contributes in the increase morbidity and mortality of stroke, heart failure, and renal failure. The morbidity and mortality of hypertension were influenced by various risk factors, the height of blood pressure and the lenght of illness. The mechanism of hypertension up to now remains unclear. Recently, endothelial dysfunction has been associated with hypertension. The aims of this study were to obtain the level of sVCAM-1 and microalbuminuria (MAU) in primary hypertension, to analyse the relationship between sVCAM-1 level and MAU, to analyse the influences of age, gender, obesity, control of hypertension, length of illness, and the level of LDL cholesterol on sVCAM-1 level and MAU.

Sixty five non diabetic subjects with hs-CRP level < 5 mg/L and protein urine < 3 + were enrolled in this cross sectional study. The level of sVCAM-1 were performed on all subjects by ELISA using reagents from R&D system, while MAU was determined by calculated the albumin : creatinine ratio in the urine. The level of LDL cholesterol was performed by homogenous enzymatic assay.

The results indicated that the proportion of increase of sVCAM-1 level was 81.5% and MAU was 27.7% in primary hypertension. Increase of sVCAM-1 level and MAU were found more frequently in older subjects, male, uncontrolled hypertension, length of illness more than 10 years, and obese subject. The results of multivariate analysis with multiple regression showed that sVCAM-1 level significantly correlated with age, mean arterial pressure (MAP), and LDL cholesterol level, but did not correlate with gender, and length of illness. The relationship could be formulated as: sVCAM-1 level = 175 + 9.7 x age (years) + 5.9 x MAP ( mm Hg) -- 2.9 x LDL cholesterol level (mgldL) with R2 adjusted 23.1%. There were no correlation between MAU with age, gender, MAP, obesity, ienght of illness, and LDL cholesterol level. The level of sVCAM-1 did not correlate with albumin:creatinine urine ratio (MAU).

Based on high proportion of increased sVCAM-1 and MAU, it is concluded that endothelial dysfunction occur in primary hypertension. The level of sVCAM-1 significantly correlates with age, MAP, and LDL cholesterol level, while MAU does not correlate with these variables. There is no correlation between sVCAM-1 level and MAU."

"Latar Belakang: Cisplatin merupakan kemoterapi efektif dengan spektrum luas. Efek terapeutiknya bertambah bermakna pada peningkatan dosis. Namun aplikasi dosis tinggi (>50 mg/m2) dibatasi nefrotoksisitasnya yang berat.Tujuan: Mempelajari efek cisplatin terhadap aktivitas eritropoiesis, kadar eritropoietin dan fungsi ginjal pasien tumor padat ganas.Metode dan Cara : Studi pre & post sejak Nopember 2004 sampai Januari 2005 dilakukan pada 14 pasien kanker tumor solid (KNF, Osteosarkoma, Ca paru) yang mendapat rejimen kemoterapi mengandung cisplatin dosis 70-100 mg/m2. Pengambilan sampel dilakukan pra, pasta kemoterapi 1 dan II, dengan rentang 21 hari. Analisis univariat dilakukan terhadap usia, Janis kelamin, Janis tumor dan stadium klini.k Dilakukan analisis bivariat pads komponen eritropoiesis, kadar EPO dan TKK hitung..Hasil : Didapatkan tumor solid berupa karsinoma nasofaring (88,24%), osteosarkoma (5,88%) dan adenokarsinoma pare (5,88%). Di mana stadium III (70,6%) dan stadium IV (29,4%). Didapatkan penurunan nilai Hb bermakna pasca siklus 110,74% (p = 0, 029)_ Pasca siklus H, Hb turun 1% (p = 0,37). Evaluasi pasca 2 siklus, lib turun 7,7% (p 0, 035). Hasil yang sama didapatkan pada nilai Ht, pasca kemoterapi siklus I (p = 0,03) dan pasca 2 siklus (p = 0, 008). Sedangkan pasca siklus II tidak bermakna (p = 0,594). Jumlah eritrosit pasca siklus I turun 13% (p = 0,00) dan pasca siklus II turun 8,7% (p = 0,00). Jumlah eritrosit turun 20,8% pasca 2 siklus (p = 0,00). Pasca 2 siklus, indeks retikulosit turun 1,59% (p = 0,975). Kadar eritropoietin pasca siklus I turun 12,7% (p = 0,73), pasta siklus II turun 20% (p = 0,03). Pasca 2 siklus didapatkan penurunan eritropoietin 30% (p = 0,925). TKK hitung mengalami penurunan pasta siklus 112,65% (p = 0,052) dan Il 0,4% (p = 0,157). Pasca 2 siklus TKK hitung turun sebesar 13% (p = 0,052). Terdapat korelasi lemah antara eritropoietin dan jumlah eritrosit pasca siklus H. Tidak didapatkan korelasi antara eritropoietin dengan Hb, indeks retikulosit dan TKK hitung.Kesimpulan: Pemberian cisplatin dosis tinggi (70-100 mg/m2) menyebabkan penurunan eritropoiesis, TKK hitung. Penurunan kadar eritrbpoietin tidak berkorelasi gagal ginjal akut Penurunan jumlah eritrosit disebabkan pula oleh rendahnya nilai eritropoeitin.

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Background: Cisplatin (Cis diaminodichloro Platinum II) is known as an effective broad spectrum anti tumor. Even though, the nephrotoxicity is one of serious side effects. The accumulation of toxic effects against to tubules area, where erythropoietin is produced, causes acute renal failure and anemia.Purpose: To study the effect of 2 cycles cisplatin against erythropoiesis, erythropoietin level and creatinine clearance at patients with solid tumor cancer.Methods: Pre and post study was done to 14 solid tumor cancer patients that receive high dose cisplatin regiment (70-100 mglm2). Hb, Ht, erythrocyte count, erythropoietin level and calculated creatinin clearance test were determined before each cycle. Age, sex, tumor type, clinical stages were evaluated Statistical analysis was done with student T and Wilcoxon Rank and Pearson correlation.Results: Tumors were NPC 88.24%, Adeno Ca 5.88% and Osteosarcoma 5.88%. Clinical stage Ili 70.6% and IV 29.4%. There were decline level among groups after 1" cycle in Hb (10.74%, p=O.029), Ht (7.6%, p=0.03), erythrocyte count (13%, p=0.OO), erythropoietin level (12.7%, p=4.73) and creatinin clearance (12.65%, p4'.1052). After 2°d cycle, there were decline in Hb (1%, pl.37), Ht (1.46%, p 4l.59), erythrocyte count (8.7%, p=0.00), erythropoietin level (20%, p.03) and creatinin clearance (0.4%, p 0.15).Reticulocyte index was not reduce after 1" and 2"d cycle. After 2 cycles assessment, there were decline level in Hb (7.7%, p=0.035), Ht (48.7%, p=0.008), erythrocyte count (20.8%, p=0.00), erythropoietin level (30%, p4.).92) and creatinin clearance (13%, p=0.022).There is a low correlation between erythropoietin level and erythrocyte count after 1 s` (r-0,397, p=0,159) and 2nd cycle (r x.46, p l.09). Variable's correlation between erythropoietin level and Hb, reticulocyte index, erythrocyte count did not reach statistical significance.Conclusion: High dose cisplatin (70-100 mglm2) cause decrease in eritropoiesis process and creatinin clearance. Decreasing erythropoietin level is not affected by acute renal failure. Low erythrocyte count is also caused by low level of erythropoietin."

"Latar Belakang. Prevalensi malnutrisi energi-protein (MEP) tinggi pada pasien penyakit ginjaI kronik yang menjalani hemodialisis (PGK-HD), dan MEP merupakan penyebab meningkatnya morbiditas dan mortalitas. Berbagai upaya telah dilakukan untuk mengatasi MEP pada pasien PGK-HD, antara lain dengan pemberian nutrisi parenteral intradialisis (IDPN). Dari beberapa penelitian yang telah dilakukan didapatkan basil yang masih kontroversial mengenai manfaat IDPN.Tujuan. Menilai efek IDPN terhadap konsentrasi albumin dan prealbumin serum selama prosedur HD; menilai efek IDPN terhadap indeks masa tubuh (IMT), konsentrasi albumin dan prealbumin serum setelah pemberian IDPN 2 kali seminggu selama 6 minggu, dan efek IDPN terhadap konsentrasi albumin dan prealbumin serum 3 minggu setelah pemberian IDPN dihentikan.Metodologi. Studi intervensional-prospektif selama 9 minggu dilakukan pada pasien PGK-HD usia 20-65 tahun yang telah menjalani HD minimal satu tahun, konsentrasi albumin serum < 3,5 g/dL, tidak menderita penyakit infeksi berat, keganasan, sirosis had, diabetes melitus tidak terkontrol, atau gagal jantung berat, di unit HD RS Ciptomangunkusumo, RS Islam Cempaka Putih, dan RS PGI Cikini Jakarta. Subyek penelitian diberikan IDPN 2 kali seminggu selama 6 minggu, dan diukur konsentrasi albumin, prealbumin, c-reactive protein (CRP) sebelum dan setelah HD+IDPN pertama dan HD+IDPN keduabelas. IMT diukur sebelum dan setelah 6 minggu pemberian IDPN. Konsentrasi albumin, prealbumin serum 3 diukur kembali 3 minggu setelah pemberian IDPN dihentikan. Dilakukan uji-t berpasangan atau uji Wilcoxon sesuai dengan tujuan penelitian.Hasil. Selma periode Februari 2005-Maret 2006 terkumpul 14 subyek, 1 subyek meninggal setelah mendapat IDPN selama 6 minggu. Didapatkan peningkatan tidak bermakna konsentrasi albumin serum (3,24 ± 0,38 menjadi 3,34 ± 0,56 g/dL, P 0,341-dan 3,26 ± 0,40 menjadi 3,47 ± 0,55, P = 0,053), dan peningkatan bermakna prealbumin (18,76 ± 7,92 menjadi 22,37 ± 10,24 mg/dL, P = 0,033 dan 16,94 ± 7,81 menjadi 23,16 + 17,21 mgldL, P = 0019), berturut-turut setelah HD+IDPN pertama dan keduabelas. Setelah HD+IDPN 2 kali seminggu selama 6 minggu, didapatkan peningkatan tidak bermakna IMT (21,75 + 2,98 menjadi 21,95 ± 3,27, P = 0,139), konsentrasi CRP serum (38,46 + 54,92 menjadi 60,04 ± 86,54 mg/L, P = 0,826), konsentrasi albumin serum, baik dibandingkan sebelum HD+IDPN pertama dengan keduabelas (3,24 ± 0,38 menjadi 3,26 ± 0,40 gldL, P = 0,795), maupun dibandingkan setelah HD+IDPN pertarna dengan keduabelas (3,34 ± 0,56 menjadi 3,47 ± 0,55 gldL), tetapi didapatkan penurunan tidak bermakna prealbumin jika dibandingkan sebelurn HD+IDPN pertarna dengan keduabelas (18,76 ± 7,92 menjadi 16,94 ± 7,81 mg/L, P = 0,109), dan peningkatan tidak bermakna jika dibandingkan setelah HD+IDPN pertama dengan keduabelas (22,37 + 10,24 menjadi 23,16 + 17,21 mgfL). Tiga minggu setelah IDPN dihentikan, didapatkan peningkatan tidak bermakna konsentrasi albumin serum (3,26 ± 0,40 menjadi 3,30 ± 0,31, P = 0,699), penurunan tidak bermakna prealbumin (16,94 ± 7,81 menjadi 16,65 ± 6,72, P = 0,552).KesimpuIan. Pemberian IDPN dapat meningkatkan konsentrasi prealbumin serum dan mencegah menurunnya albumin dalam setiap sesi HD. Pemberian IDPN 2 kali seminggu selama 6 minggu dapat menstabilkan kecenderungan menurunnya IMT dan konsentrasi albumin serum, tetapi tidak dapat menstabilkan prealbumin, dan konsentrasi albumin serum dapat bertahan selama 3 minggu setelah IDPN dihentikan.

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Backgrounds. In chronic kidney disease patients undergoing hemodialysis (CKDHD), prevalence of protein-energy malnutrition (PEM) is high, and it is associated with increased morbidity and mortality. Many interventions to improve PEM in CKD-HD patients have been conducted, one of them is intradialytic parenteral nutrition (IDPN). Data from many studies showed that beneficial effect of IDPN to improve PEM in CKD-HD patients is still controversial.Objectives. To assess effect of IDPN on serum albumin and prealbumin concentration during each HD procedure, effect of IDPN on body mass index (BMI), serum albumin and prealbumin concentration after administration twice a week for 6 weeks, and effect of IDPN on serum albumin and prealbumin concentration 3 weeks after IDPN was discontinued.Methods. Prospective-interventional study for 9 weeks was conducted in CKD patients undergoing maintenance HE) at least for 1 years, age 20-65 years old, not suffering severe infection disease, malignancy, cirrhosis hepatis, severe heart disease, acute coroner syndrome, and serum albumin concentration < 3.5 gldL, at HD unit Ciptomangunkusumo hospital, Islamic Cempaka Putih hospital, and PGI Cikini hospital, Jakarta. The subjects received IDPN consisting of 9% essential and non essential amino acids, 40% glucose, and 20% fat emulsion, twice a week for 6 weeks. Before and 2 hours after the HD+151 IDPN and HD+12th IDPN, serum albumin, prealbumin, c-reactive protein (CRP) concentration were measured. BMI was measured before and after subjects received IDPN for 6 weeks. Serum albumin, prealbumin were measured again 3 weeks after IDPN discontinued. Dependent sample t-test or Wilcoxon test was used to analyse the data.Results. During February 2005 - March 2006, 14 patients were included into subjects of this study. There were no significant increase in serum albumin concentration (3.24 ± 0.38 to 3.34 ± 0.56 g/dL, P = 0.341 and 3.26 + 0.40 to 3.47 ± 0.55, P = 0.053), and significant increase in prealbumin (18.76 + 7.92 to 22.37 + 10.24 mg/dL, P = 0.033 and 16.94 + 7.81 to 23.16 + 17.21 mgldL, P = 0.019), respectively after the HD+15tIDPN and HD+12thIDPN. After IDPN administration twice a week for 6 weeks, there were no significant increase in BMI (21.75 + 2.98 to 21.95 + 3.27, P = 0.139), serum CRP (38.46 + 54.92 to 60.04 + 86.54 mg/L, P = 0.826), and albumin concentration, when it was compared before the HD+15`IDPN and HD+12tIDPN (3.24 ± 0.38 to 3.26 + 0.40 gldL, P = 0.795), and when it was compared after the HD+1$`IDPN and HD+12thIDPN (3.34 ± 0,56 to 3.47 + 0.55 g/dL,), but there was no significant decrease in prealbumin when it was compared before the HD+15`IDPN and HD+12'hIDPN (18.76 + 7.92 to16.94 + 7.81, P = 0.109), and there was no significant increase when it was compared after the HD+15tIDPN and HD+12thIDPN (22,37 + 10,24 to 23,16 + 22,10 mg/L). Three weeks after IDPN discontinued, there were no significant increase in serum albumin concentration (3.26 + 0.40 to 3.30 + 0.31 gldL, P = 0.699), but no significant decrease in prealbumin (16.94 + 7.81 to 16.65 + 6.72 mgldL, P = 0.552).Conclusions. IDPN administration during each HD session could increase serum prealbumin concentration and prevent the decrease of albumin, whereas IDPN administration twice a week for 6 weeks could stabilize the downward trend in BM1 and serum albumin concentration, but couldn't stabilize prealbumin, the serum albumin concentration could be stabilized for 3 weeks after IDPN administration discontinued."

"Dalam penelitian ini terbukti secara bermakna bahwa depresi menurunkan kualitas bidup penderita pria pasca IMA dalam jangka pendek. Dalam penelitian ini tidak terbukti secara bermakna adanya hubungan antara pengobatan psikofarmaka (diazepam) pada saat teIjadinya IMA, usia, bipertensi, DM, lama pendidikan formal, aspek spiritual dan dukungan sosial dengan kualitas bidup setelah 2 bulan pasca IMA.

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In this study, it was proven that depression significantly decreased the quality of male bids after IMA in the short term. In this study, it was not proven that there was a significant relationship between psychopharmaceutical treatment (diazepam) at the time of IMA, age, bitenasis, DM, length of formal education, spiritual aspects and social support with the quality of bidup after 2 months after IMA."

"Latar belakang: Tromboemboli vena (TEV) dapat bermanifestasi sebagai trombosis vena dalam (TVD) ataupun emboli paru (EP). EP sebagai komplikasi TVD dapat berakibat fatal. TVD umumnya terjadi disebabkan multipel faktor risiko seperti penyakit penyerta (komorbid), faktor provokasi, gangguan hemostasis dll. Gangguan fungsi hemostasis berupa keadaan protrombotik sudah dimulai dari awal stadium penyakit ginjal kronik (PGK). Menurunnya laju filtrasi glomerulus berkolerasi dengan peningkatan TEV. Mekanisme pasti bagaimana terjadinya TVD pada penderita PGK sampai saat ini masih belum jelas. Tujuan: Untuk mengetahui profil hemostasis dan faktor risiko yang berhubungan dengan TVD pada pasien PGK. Metode : Penelitian potong lintang retospektif dengan memakai data sekunder pada pasien PGK stadium 3-5 yang dirawat inap selama 1.5 tahun antara Oktober 2011- April 2013. Faktor risiko TVD yang diteliti meliputi DM, CHF, stroke iskemik, faktor provokasi, usia lanjut dan penurunan LFG. Analisis bivariat dan multivariat dilakukan dengan regresi logistik untuk mendapatkan faktor risiko yang paling berhubungan dengan terjadinya TVD pada pasien PGK. Adanya perbedaan proporsi pada kedua kelompok dinilai dengan analisis bivariat. Hasil: Proporsi TVD kasus baru yang telah dikonfirmasi dengan USG Doppler ditemukan sebesar 8% (91 dari 1115 pasien). Subyek penelitian sebanyak 160 pasien terdiri atas kelompok TVD 75 orang dan kelompok Non TVD 85 orang, subyek juga terbagi dalam kelompok Dialisis 77 orang dan Non Dialisis 83 orang. Pada pemeriksaan hemostasis ditemukan persentase rasio APTT <0.8 (1.9%), rasio PT <0.8 (0%), INR <0.8 (0%), fibrinogen >400 mg/dl (56.2%) dan D-Dimer >500 μg/l (87.5%) pada keseluruhan pasien PGK. Kadar fibrinogen lebih tinggi pada kelompok TVD daripada Non TVD. Tidak ada perbedaan hemostasis antara kelompok Dialisis dan Non Dialisis. Dari beberapa faktor risiko TVD yang diteliti, DM merupakan faktor risiko yang bermakna sesuai p <0.001, OR 4.5 (95% KI 2.3-8.8). Kesimpulan: Sebagian besar pasien PGK cenderung mengalami hiperkoagulasi. Pasien PGK dengan DM berisiko untuk mengalami TVD. DM bersama faktor risiko lain dapat menjadi predisposisi terjadinya TVD pada PGK.

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Background: Venous thromboembolism (VTE) may manifest as deep vein thrombosis (DVT) or pulmonary embolism (PE). PE as a major complication of DVT and can lead to potentially fatal. DVT can occur as the result of multiple risk factors such as comorbidities, provoked factors, abnormal hemostasis functions and others. Chronic kidney disease (CKD) is typically associated with a prothrombotic tendency in the early stages of the disease. The declining of glomerular filtration rate (GFR) is correlated with increasing of VTE. The exact mechanism of how DVT develops in CKD patients remains unclear.

Aim: To determine the hemostasis profiles and risk factors associated with DVT in CKD patients.

Methods: Retrospective cross sectional study was hold by review the medical records from stage 3-5 CKD patients that hospitalized during 1.5 years (October 2011 - April 2013). Multiple risk factors for TVD such as CHF, stroke ischemic, provoked factors, elderly and decreasing of eGFR were examined. Bivariate and multivariate analysis with logistic regression performed to obtain the most risk factors associated with the occurrence of TVD in CKD patients. The differences of proportion between both groups were assessed by bivariate analysis.

Results: The proportion of first DVT confirmed by doppler ultrasound was 8% (91 of 1115 patients). 160 patients were divided into groups. 75 and 85 patients comprised the group with DVT-Non DVT as well as 77 and 83 patients comprised the group with Dialysis-Non Dialysis. We found the APTT ratio <0.8 (1.9 %), PT ratio <0.8 (0 %), INR <0.8 (0 %), fibrinogen level >400 mg/dl (56.2 %) and DDimer level >500 μg/l (87.5 %) in all CKD patients. The level of fibrinogen was higher when DVT group compared to Non DVT group. There was no significant differences of hemostasis functions between Dialysis and Non Dialysis group. Multivariate analysis demonstrated that diabetes mellitus (p<0.001, OR: 4.5; 95% CI: 2.3 to 8.8) was associated with DVT in CKD patients among all risk factors.

Conclusion: Most CKD patients tend to have hypercoagulation. Diabetes was associated with DVT risk in CKD patients. Diabetes with other risk factors could be as predispotition factors for DVT in CKD in this study."