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The preparation of liposomes derived from mixed micelles of lecithin added by sodium cholate, followed by dialysing using hemoflow high flux F60S

Erni H. Purwaningsih, Rolf Schubert (Faculty of Medicine University of Indonesia; Institute of Pharmaceutical Technology University of Freiburg, 2004)

 Abstrak

Liposomes are used for drug carriers meaning that drugs are incorporated in the membrance or the vesicle of the liposomes. In this study, liposomes were prepared from mixed micelles, consisting of phosphatidylcholone, without or with cholesterol and sodium cholate was added in several ratios namely 0.44; 0.55; 0.63; 0.70; 0.90 and 1.10. After the preparation, the sodium cholate has been removed by a dialysis membrance, using the Hemoflow High Flux, which is generally used for haemodialysis. The Hemoflow High Flux is a tool an effort to obtain a simple, quick, effective method for removing sodium cholate in the process of preparing liposomes. The effectiveness of this tool was proved by the particle size of the liposome which was measured by the Malvern Particle Sizer. The particle size of the liposome consisting of phosphatidycholine (PC) without cholesterol and with cholesterol was 63-68 nm at all ratios andapproximately 125 nm at the ratio of 0.55; 0.63; 0.70, respectively. The particle size of the liposome tended to be smaller after dialyzing although the concentration of lipids tended to increase. However, a larger amount of buffer solution has to be used with this method.

 Metadata

No. Panggil : AJ-Pdf
Entri utama-Nama orang :
Entri tambahan-Nama orang :
Subjek :
Penerbitan : [Place of publication not identified]: Faculty of Medicine University of Indonesia; Institute of Pharmaceutical Technology University of Freiburg, 2004
Sumber Pengatalogan : LibUI eng rda
ISSN : 23563656
Majalah/Jurnal : Makara Journal of Health Research
Volume : Vol. 8, No. 2, Desember 2004: Hal. : 49-52
Tipe Konten : text
Tipe Media : computer
Tipe Carrier : online resource
Akses Elektronik : http://journal.ui.ac.id/index.php/health/article/view/326
Institusi Pemilik : Universitas Indonesia
Lokasi : Perpustakaan UI, Lantai 4, R. Koleksi Jurnal
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No. Panggil No. Barkod Ketersediaan
AJ-Pdf 03-20-100378148 TERSEDIA
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