Reactions of cisplatin hydrolytes with thiols 3: reactions of cis-[Pt(15NH3)2(H2O)2]2+ with glutathione
(Lembaga Penelitian Universitas Indonesia, 2006)
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| The reaction of cis-[Pt(15NH3)2(H2O)2]2+ (3) with glutathione (GSH) was investigated in aqueous solution. In this reaction, the ammine in the platinum complex formed was liberated. Surprisingly two chelate rings were observed, six-membered-S,O-chelate ring complex cis-[Pt(15NH3)2(SG-S,O) (7) and five-membered-S,N-chelate ring complex cis-[Pt(15NH3)2(SG-S,N)] (8). The bis (thiolate) platinum(II) complex, cis-[Pt(15NH3)2(SG)2] (9) was always present in this reaction in any mole ratio used. The dinuclear sulphur-bridged complex (10), giving a broad peak in 15N NMR, was only present in very tiny amounts. |
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| Penerbitan : | [Place of publication not identified]: Lembaga Penelitian Universitas Indonesia, 2006 |
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| Majalah/Jurnal : | Makara: Sains |
| Volume : | 10 (1) April 2006: 19-23 |
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