Full Description
| Cataloguing Source : | |
| ISSN : | |
| Magazine/Journal : | Makara: Sains |
| Volume : | 11 (2) November 2007: 56-62 |
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| Electronic Access : | |
| Holding Company : | Universitas Indonesia |
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- Availability
- Digital Files: 1
- Review
- Cover
- Abstract
| Call Number | Barcode Number | Availability |
|---|---|---|
| AJ-Pdf | 03-20-849793089 | TERSEDIA |
| No review available for this collection: 118307 |
Abstract
Infeksi Human Papillomavirus (HPV) memiliki korelasi yang erat dengan insidensi kanker serviks. Pada penelitian ini dikembangkan chimeric virus like particles (cVLP) sebagai kandidat vaksin untuk mencegah kanker serviks. cVLP dikembangkan dengan mensubstitusi epitop dari protein HPV-18 L1 dan HPV-52 L1 dengan protein HPV-16 L1. Pada penelitian ini ditemukan empat desain vaksin kimerik, yaitu ANN1, ANN2, HMM1, dan HMM2. Kajian ini akan menentukan efek dari modifikasi pos translasi. Berdasarkan kajian in silico, modifikasi pos translasi yang dominan adalah glikosilasi.
Computational Study of Post Translation Modification in Chimeric Virus Like Particles Vaccine of Human Papilloma Virus with Virion Capsid L1. The Human Papillomavirus (HPV) infection has a tight correlation with the incidence of cervical cancer. Chimeric virus like particles (cVLP) has been developed as vaccine candidate for preventing cervical cancer. cVLPs are improvement of Virus Like Particles (VLP) by substituting the epitope of L1 HPV -18 and -52 protein to L1 HPV -16 protein. They are ANN1, ANN2, HMM1, and HMM2. The impact of post translation modification will be determined. Based on In Silico study, the dominant post translation modification is glycosylation.
Computational Study of Post Translation Modification in Chimeric Virus Like Particles Vaccine of Human Papilloma Virus with Virion Capsid L1. The Human Papillomavirus (HPV) infection has a tight correlation with the incidence of cervical cancer. Chimeric virus like particles (cVLP) has been developed as vaccine candidate for preventing cervical cancer. cVLPs are improvement of Virus Like Particles (VLP) by substituting the epitope of L1 HPV -18 and -52 protein to L1 HPV -16 protein. They are ANN1, ANN2, HMM1, and HMM2. The impact of post translation modification will be determined. Based on In Silico study, the dominant post translation modification is glycosylation.