Aktii'vitas antiinikroba penisilifla terletak padakeutuhan cinciri j3-laktam. Gugus karbonil pada cincin Klaktam mempunyai frekuensi yang spesifik pada 1780 - 1770ci -( -. Penelitian mi Kan memarfaatkan kespesifikan resapanpacla ciaerah inframerah mi dalain analisiskuarititatif derivat penisi1irtaTujuah pertelitiari ml adalah membandingkan has 11penetapan kadar secara spektrofotoineti inframerah denganpotensi ainoksisilina dan untuk merigetahui sejauhmana suhudan iamanya pemanasari berpengaruh terhadap kadar danpotensi amoksisiiiria, dergan cara memariaskannya pada suhu40°C dan 60°C selama 10 menit, 20 menit, 40 meriit, 1 jam,2 jam, 4 jam, 8 jam, 16 jam, 1 han, 2 han, 4 han, 8han, 15 han, dan I bul an. Hasil pemanasan tersebutdipeniksa kadarnya secara sp .ektrofotometni inframerahmenggunakan teknik tab1et 1 KBr -dan potensinya. Penetapanpotensi dilakukan dergan uiietoda difusi. Sebagai reservoirlarutan ataoksisilina di.gunakan silinder besi tahan karat,derigan kuman uji Sarciri.a lutea ATCC 9341 'pada medium 11.Dari pengujian statistik terhadap amoksisilina baku,ternyata ads korelasi antara hasil penetapan kadar secaraspektrofotoirietni inframerah dengari poterisi amoksisilina.Penetapan kadar amoksisilina akibat pemanasan cenderungmembenikan hasil lehih tinggi dibandingkan dengan potensi, disebabkan karena •hasil urai yang terbentukrnengganggu pada penetapan kadar secara inframerah Olehsebab itu, metoda spektrofotometri infrarnerah han ya dapatdigunakan untuk penetapan kadar amoksisilina yang belummengalami penguraian.
The activity of penicillin antimicrobial is in the totality ofP-lactam ring. The group of carbonyl in P-lactam has a spesificvibration of frequency, that is 1780 - 1770 cm. This study willtake the advantage of this spesific penetration on the infra redarea in quantitative analysis of penicillin's derivate.The aim of this study is to compare the fixing of concentrationwith infra red spectrophotoinetry and amoxycillin 's potency and alsowe want to know how far the temprature and duration of heatinginfluence the concentration and amoxycillin's potency, by heating itat 400C and 60°C in 10 minutes, 20 minutes,40 minutes, an hour, 2hours, 4 hours, 8 hours, 16 hours, a day, 2 days, 4 days, 8 days anda month. The concentration of the heating's results were examinedwith infra red speetrophotometry using Or pellet and tested for itspotency. Diffusion method is used to settle the potency. An anti corrosioncylindrical iron with Sarcina lutea A1YX 9341 microbe instage-11 is used as the reservoir of amoxycillin solution.Statistically test to standard of amoxycillirz, we see there isa correlation between fixing the concentration with infra redspectrophotoinetry and ainoxycill in's potency. The fixing ofainoxycillin's concentration caused by heating is higher if wecompare with potency, it's because of the degradation formedinfluenced it. Therefore infra red speetrophotometry method is usedjust for fixing the concentration of undegr&Iated amoxyciilin |
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