Dewasa mi gentamisin masih inerupakan obat yang pentinguntuk mengatasi infeksi berat kuman gram negatif; Karena batas keamanan gentamisin sempit maka hal ml merupkrn masalah dalam penggunaannya. Telah dilakukan pengukuran kadar gentamisin dalam serum dari 16 orang penderita pasca bedah di Bagian Kebidanan 115CM. Setiap penderita disuntikkan 80 mg gen,tamisin secara intramuskuler setiap 12 jam,selama 5 hari.pengambilam--.saxpel'.'dila kukan pada saat sebeluzn d.isuntikkan,3- jam,1 jam, 13- jam,3jam.,8 jam, 12 jam seteiah pemberian dan sesaat sebelum diberikan dosisPenentuan kadar gentamisin dalam serum dilakukan dengan cara difusi agar menurut Sabath 1930 (26) ,yang telahfikasi. Basil pengukuran yang diperoleb kemudian dicari kadar puncak dan dihiung waktu paruh gentamisin dalam serum, Dari penelitian ini didapatkan kadar puncak yang bervariasiantara 2,6 santpai 9,3 mcg/ml, ditemukan kadar subtera-peutik pada 2 penderita, waktu paruh rata-rata 2,4 jam dengan variasi antara 1 1,6 sampai Li.,6 jam. Dengan cara dan dosis yang lazim digunakan saat mi di. Bagian Kebidanan RSCM tidak ada kecenderungan terjadi toksisitas a k i b a t kumulasi, tetapi pada sebagian penderita tampaknya kadar terapeutik tidak tercapai. Gentaniicin is still an important drug to overcome seriousinfections due to gram-negative pathogens.The narrow margin of safety of this drug raises proble!n in its therapeuticuses.Serum levels of gentanilcin were determined from 16 postoperativepatients in the Gynaecological Department of RSCMEach patient was given intramuscular injection of 80 mg ofgentainicin every 12 hours for five days.Blood sampling wasdone at the moment before injection and half, one, one and ahalf, three, eight, twelve hours after administration and atthe moment before the last dose was given.Gentaniicin level in the serum was determined using modified agar diffusion assay according to Sabath 1980 (26).From the result of the measurement the peak level was detectedand calculation of half-life inerum was done. Peak level between 2,6 and 9,3 mc/m1 were obtained from this studies in which two-patients.--showed subtherapeuticlevels.The mean of half-life was 2,4 hours ; range between1,6 and 4,6 hours. It is concluded that this dose regimen does not likely to cause accumulation of drug. It may otherwise gives subtherapeut.ic levels. |