Masaiah disolusi. zat. aktif obat dalam sediaan: padatoral banyak mendapat perhatian mengingat bahwa laju disolusiobat memegang peranan yang penting daiwa merainaikan" bi6avajlabjljtas dan bioekivalensi " obat secara in vitro.Banyak metoda yang telah dilakukan dalam usaha meninkatkan laju disolusi dan obat, khususnya yang mernpunyai klarutan yang rendah dalam air atau cairan lambung...Dari sekian banyak metoda-metoda, kami memilih untuk memat pengaruh polisorbat. 80, dioktil sodium sulfo suksinatdan glismn terhadap laju disolusi piroksikam dan kioramfe -nikol..Metoda yang kami lakukan dalam penelitian mi adaiahmetoda kristalisasi, metodapenambahan langsung dan metodagranulasi basah. Adapun uji laju disolusi dilakukan denganmetoda It basket ' pada kecepatan rotasi 100 rpm, sebagai mdia disolusi digunakan HC1 0,1 N, pada temperatur 37°C0,5°C. Sampel diambil pada menit ke 5, 10 1, 15, 20 9, 25, 30,£4.5 dan 60 setelah percobaari dimulaTL. Jumlah obat yang me -larut dalam media disolusi ditentukan dengan spektrofotometer u.v. pada panjang gelombang maksimumnya, dimana untukpiroksikam pada A 334 nm, dan kloramfenikol pada A 278mm diban.dingkan terhadap larutan standar pembanding.Hasil penelitian menunjukkan bahwa pengaruh adanya..polisorbat 80 pada piroksikam balk dengan metoda kristalisasidengan kadar 2,5 % atau metoda granulasi basah danpencampuran langsung dengan kadar 2,0 % meningkatkan lajudisolusinya, demikian pula metoda granulasi basah .glisinkadar 2,,0 %.Metoda kristalisasi kioramfenikol dalam larutan polisorbat80 2 9 5 % maupun polisorbat 80, diokthl sodium sulfo suksi-'nat dan glisin dengan kadar 17,5 % baik dengan metoda pencampuranlangsung maupun metoda granulasi basah tidak meningkatkanlaju disolusi kioramfenikol.
The problems in drug dissolution of solid, oral dosageforms draw a. lot.. att.jxtion. because drug dissolution rateplays important role in.predicting H bioavailabilty andbioequivalent it of drug in vitro.Many methods have been done to increase the drugdissolution rate, especially for those which have slightsolubility in water or gastric liquid Amoung those methods, we chose to observe the effect of the addition ofpolysorbate 80, dioctyl sodium sulfo succinate and glycinein the increating the dissolution rate of piroxicam andchioramphenicol.The methods carried out in the experiment were crystallizationmethod, direct mixing method and wet granula -tion method. Observation of the dissolution rate were doneusing the U basket's method 11 on the rotation rate of 100rpm, withHC1 0,1 N as medium at temperature of 370 LOV5°CThe sample were taken. on 5 th , 10tb , 15th , 20tb125th30th , kSth , and 60th minutes after the experiment had beenstarted The amount of drug that disolved in the dissolu -tion medium were determined by using ultra violetspectrophotometerat their maximum wave lenght, that is at 1 334nm for piroxicam, and 278 nm for chioramphenicol by cog paring to the standard solution the original drug whichconcentration had already been known.The experiment showed that the addition of 2,5 %solution of polysorbate 80 in the crystallization methodof piroxicam or 2,0 % concentration in wet granulation mthod and direct mixing method could increase their dissolutionrate, and also the addition of glycine 2,0 % andgave the same effect in wet granulation method.While in chloram.phenicol the existence of surfactantspolysorbate 80 2,5 %, polysorbate 80, dioctyl sodium sulfasuccinate and glycine 17,5 % couldn't increase the disso -lution rate in all three methods mentioned above |
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