:: Artikel Jurnal :: Kembali

Artikel Jurnal :: Kembali

Bioprospect of Lovastatin in Aspergillus spp. from University of Indonesia Culture Collection (UICC)

by Wibowo Mangunwardoyo, Yanti Rafliyanti and Dadang Kusmana (Department of Biology. Faculty of Mathematics and Natural Sciences. University of Indonesia, 2012)

 Abstrak

The aim of this research is to select and analyse lovastatin from isolated molds of Aspergillus spp. from University of Indonesia Culture Collection (UICC). Lovastatin is an inhibitor 3 hydroxy-3-methylglutaryl-coenzyme-A reductase (HMG-CoA reductase) enzyme and a competitive inhibitor of the biosynthesis of cholestrol. The result revealed that out of 40 cultures, 18 cultures (45%) produced lovastatin and 22 cultures (55%) were negative. Aspergillus flavus UICC 360 showed the biggest lovastatin production compared to a number of selected cultures. Thin Layer Chromatography (TLC) analysis showed an amount of Aspergillus with same similarities of Rf value compared to the standard High Performance Chromatography (HPLC) analysis which confirmed that lovastatin Aspergillus flavus UICC 360 has the same retention time with the standard (13.2) minutes.

 File Digital: 1

 Metadata

No. Panggil : AJ-Pdf
Entri utama-Nama orang :
Entri tambahan-Nama orang :
Subjek :
Penerbitan : Depok: Department of Biology. Faculty of Mathematics and Natural Sciences. University of Indonesia, 2012
Sumber Pengatalogan :
ISSN :
Majalah/Jurnal : World Applied Sciences Journal
Volume : Vol. 16 (2): 183-188, 2012
Tipe Konten :
Tipe Media :
Tipe Carrier :
Akses Elektronik :
Institusi Pemilik : Universitas Indonesia
Lokasi :
  • Ketersediaan
  • Ulasan
No. Panggil No. Barkod Ketersediaan
AJ-Pdf 08-23-50052649 TERSEDIA
Ulasan:
Tidak ada ulasan pada koleksi ini: 20280618