Synthesizing derivatives from cyclopentanone analogue curcumin and their toxic, antioxidant and anti-inflammatory activities
Yum Eryanti, Yuana Nurulita, Rudi Hendra, Yuharmen, Jufrizal Syahri, Adel Zamri ([Direktorat Riset dan Pengabdian Masyarakat UI;Universitas Riau. Departemen Kimia;Universitas Riau. Departemen Kimia, Universitas Riau. Departemen Kimia], 2011)
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ABSTRACT Three types of cyclopentanone derivatives have been synthesized from aromatic aldehyde and ketone derivatives undera base condition through aldol condensation. These cyclopentanone products were 2,5-dibenzylidene-cyclopentanone (a), 2,5-bis-(4-hydroxy-benzylidene)-cyclopentanone (b),and 2,5-bis-(4-hydroxy-benzylidene)-cyclopentanone (c)which has a yield of 63-99%. The chemical structure of these compounds were determined using UV, IR and NMRspectroscopy. In order to clarify the role of hydroxyl and amine moieties, toxic, antioxidant and anti-inflammatoryactivities were carried out. The toxic test indicated that thecompounds showed strong toxicity. In addition, the presenceof hydroxyl and amine groups on both rings of curcumin increased the antioxidant and anti-inflammatory activities. |
| No. Panggil : | J-Pdf |
| Entri utama-Nama orang : | |
| Entri tambahan-Nama orang : | |
| Subjek : | |
| Penerbitan : | [Place of publication not identified]: [Direktorat Riset dan Pengabdian Masyarakat UI;Universitas Riau. Departemen Kimia;Universitas Riau. Departemen Kimia, Universitas Riau. Departemen Kimia], 2011 |
| Sumber Pengatalogan : | LibUI eng rda |
| ISSN : | 23391995 |
| Majalah/Jurnal : | Makara : Sains |
| Volume : | Vol. 15, No. 2, November 2011: 117-123 |
| Tipe Konten : | text |
| Tipe Media : | unmediated |
| Tipe Carrier : | volume |
| Akses Elektronik : | http://journal.ui.ac.id/index.php/science/article/view/1060/973 |
| Institusi Pemilik : | Universitas Indonesia |
| Lokasi : | Direktorat Riset dan Pengabdian Masyarakat UI |
| No. Panggil | No. Barkod | Ketersediaan |
|---|---|---|
| J-Pdf | 03-19-936697566 | TERSEDIA |
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