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Artikel Jurnal :: Kembali

Combination of depot medroxy progesterone acetate and Javanese long pepper extract on body weight, hematology, and blood biochemistry as a safe contraception model

Yurnadi, Yoel Asmida, Dwi Anita Suryandari, Nukman Moeloek ([Direktorat Riset dan Pengabdian Masyarakat UI;Fakultas Kedokteran Universitas Indonesia, Fakultas Kedokteran Universitas Indonesia], 2011)

 Abstrak

ABSTRACT
The development of male hormonal contraception is based on a decrease in sperm concentration without affecting
libido and sexual potency. The combination of depot medroxy progesterone acetate (DMPA) + extract of Javanese long
pepper (JLP) with dosages of 0.94 mg and 1.88 mg decreas
es the concentration of spermatozoa. However, it remains
unknown whether the combination influences body weight, hematology, and blood biochemistry. Therefore, it is
necessary to investigate the effect of DMPA + JLP extracts on the body weight, hematology, and blood biochemistry of
male rats (RattusnorvegicusL.) using Sprague-Dawley strains. The research uses a completely randomized design (CRD); one group control and two treatment groups. In the first group, the castrated rats were given oral administration extracts of JLP (CJ) with doses of 0, 0.94, 1.88, 2.82, and 3.76 mg. In the second group, the rats were injected with 1.25mg DMPA and given an oral administration extract of JLP. Injection was given in week-0 and 12. Administration was conducted every day from week 7-18. Analysis of the normality and homogeneity of data is done before the ANOVA test. Data that is abnormal and not homogeneous are tested with non-parametric statistical Kruskal-Wallis. This study
shows that the combination of minimal doses of DMPA and administration variousdoses of extracts of JLP does not
affect body weight and hematology (erythrocyte, hemoglobin, hematocrite), and the blood biochemistry of rats, such as
the values of SGPT, SGOT, HDL, and triglycerides (p< 0.05), but rather the total cholesterol and LDL (p< 0.05). Furthermore, it is concluded that the combination of the minimal dosage of DMPA and weaned various dosages of JLP
extracts affect the total value and LDL cholesterol but do not influence body weight, nor hematology and blood biochemistry. Such combinations can be drawn on for asafe male contraceptive model t by taking into account the value of the total cholesterol and LDL during its use.

 Metadata

No. Panggil : J-Pdf
Entri utama-Nama orang :
Entri tambahan-Nama orang :
Subjek :
Penerbitan : [Place of publication not identified]: [Direktorat Riset dan Pengabdian Masyarakat UI;Fakultas Kedokteran Universitas Indonesia, Fakultas Kedokteran Universitas Indonesia], 2011
Sumber Pengatalogan : LibUI eng rda
ISSN : 23391995
Majalah/Jurnal : Makara : Sains
Volume : Vol. 15, No. 2, November 2011: 155-162
Tipe Konten : text
Tipe Media : unmediated
Tipe Carrier : volume
Akses Elektronik : http://journal.ui.ac.id/index.php/science/article/view/1065/978
Institusi Pemilik : Universitas Indonesia
Lokasi : Direktorat Riset dan Pengabdian Masyarakat UI
  • Ketersediaan
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No. Panggil No. Barkod Ketersediaan
J-Pdf 03-19-095426461 TERSEDIA
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