Activity of ethanolic extract from justicia gendarussa burm. leaves on decreasing the uric acid plasma
Katrin Basah, Berna Elya, Juheini Amin, Muhamad Iqbal Julian ([Direktorat Riset dan Pengabdian Masyarakat UI;Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Indonesia;Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Indonesia, Universitas Indonesia], 2011)
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ABSTRACT The effect of Justicia gendarussa leaves extract has been investigatedusing oxonate-induced hyperuricemic male albino rats. In this experiment thirty five male albino rats were divided randomly into seven groups. There were three group doses variations of J. gendarussa extract that were 1.3 g/kg bw, 2.6 g/kg bw and 5.2 g/kg bw; two comparison groups that were allopurinol 0.68 g/kg bw and herbal ?X? 0.85 g/kg bw; and two control groups that were induced control potassium oxonate 0.25 mg/kg bw and normal control CMC 0,5%. Intraperitoneal administration of potassiumoxonate 0.25 mg/kg bw was given one hour before administration of test drugs in eight day and plasma uric acid was measured in rats after two hours. Plasma uric acid was measured by spectrophotometric on 520 nm with enzymatic method. The results showed that all extracts could reduced uric acid level of rats. The decreasing potency of uric acid level was equal to doses increase, so the best result that can reduce uric acid level was J. gandarussa extract at a dose 5.2 g/ kg bw. This results indicated thatJ. gendarussa leaves extract may be effective for the prevention and the treatment of hyperuricemia. |
| No. Panggil : | J-Pdf |
| Entri utama-Nama orang : | |
| Entri tambahan-Nama orang : | |
| Subjek : | |
| Penerbitan : | [Place of publication not identified]: [Direktorat Riset dan Pengabdian Masyarakat UI;Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Indonesia;Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Indonesia, Universitas Indonesia], 2011 |
| Sumber Pengatalogan : | LibUI eng rda |
| ISSN : | 23391995 |
| Majalah/Jurnal : | Makara : Sains |
| Volume : | Vol. 15, No. 1, April 2011: 67-70 |
| Tipe Konten : | text |
| Tipe Media : | unmediated |
| Tipe Carrier : | volume |
| Akses Elektronik : | http://journal.ui.ac.id/index.php/science/article/view/881/840 |
| Institusi Pemilik : | Universitas Indonesia |
| Lokasi : | Direktorat Riset dan Pengabdian Masyarakat UI |
| No. Panggil | No. Barkod | Ketersediaan |
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| J-Pdf | 03-19-716427189 | TERSEDIA |
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