ABSTRAK
Tujuan: Mengetahui kesintasan hidup, respon pengobatan dan faktor yang mungkinmempengaruhi dalam penanganan karsinoma nasofaring stadium lokal lanjutMetode: Dilakukan penelitian retrospektif deskriptif analitik terhadap 391 pasienkarsinoma nasofaring stadium lokal lanjut yang berobat di Departemen RadioterapiRSCM periode Januari 2007-Desember 2011, dilihat karakteristik pasien maupuntumor. Analisis kesintasan dihitung dengan kurva Kaplan Meier dan respon radiasidianalisa menggunakan uji korelasi Spearman pada pasien yang memenuhi kriteriainklusi.Hasil: Didapatkan 70.6% pasien adalah laki laki, median usia 45 (9-86) tahun.Sebagian besar stadium IVB (32,7%) dengan tipe histopatologis WHO III palingdominan (82,4%) Kesintasan hidup 3 dan 5 tahun untuk masing-masing stadium IIB,III, IVA, IVB berturut-turut adalah 64,9%, 57,6%, 47,4%, 48,0% dan 64,9%, 43,2%,34,3%, 26,6%. Sedangkan respon komplit untuk masing-masing stadium IIB, III,IVA, IVB berturut-turut 83,3%, 73,3%, 52,6%, 45,8%. Terdapat korelasi bermaknaantara respon radiasi dengan stadium (r=0,242;p=0,038) dan antara respon radiasidan kesintasan hidup (r=-0,251;p=0,031).
ABSTRACT
Purpose: To show the overall survival rate, radiation response and factors influencedon locally advanced nasopahryngeal cancer.Method: Retrospective analytic descriptive study of 391 newly diagnosed locallyadvanced nasopharyngeal cancer patients from January 2007 till December 2011, toshow their characteristics. Overall survival rate were analyzed by Kaplan MeierSurvival curve and the radiation response correlation with other factors wereanalyzed by Spearman correlation test.Result: Most of the subjects are male (70.6%), with median age 45 (9-86) years old.Mainly on stage IVB (32,79%) with the most hystopalogic was type III WHO(82,4%). All of the subjects were analyzed for 3 and 5 years overall survival, resultedfor stage IIB, III, IVA, IVB were 64,9%, 57,6%, 47,4%, 48,0% dan 64,9%, 43,2%,34,3%, 26,6% respectively. Complete respons for stage IIB, III, IVA, IVB were83,3%, 73,3%, 52,6%, 45,8%, respectively. There were significant correlationbetween radiation response and cancer stadium (r=0,242;p=0,038) and betweenradiation response with overall survival rate (r=-0,251;p=0,031). |
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