Defisiensi besi merupakan keadaan dimana jumlah total besi tubuh berkurangyang bila berlanjut menyebabkan anemia defisiensi besi. Saat ini tersediaparameter immature reticulocyte fraction (IRF) yang menunjukkan fraksiretikulosit muda di sirkulasi yang bermanfaat menilai aktivitas eritropoiesis.Tujuan penelitian ini untuk mengetahui korelasi IRF dengan kadar besi dan feritinserum, dan saturasi transferin, serta korelasi feritin dan hepsidin serum. Penelitiandengan desain penelitian potong lintang ini melibatkan 77 subyek remaja putrisekolah yang telah haid dan mendapat suplementasi besi oral 2 kali semingguselama 12 minggu. Dilakukan pemeriksaan kadar hemoglobin, hitung retikulositabsolut, IRF, kadar besi, feritin, dan hepsidin serum serta saturasi transferin.Didapatkan korelasi bermakna dengan kekuatan sedang antara IRF dan kadar besidan feritin serum, serta saturasi transferin (berturut-turut p<0,0001, r = -0,443; p =<0,0001, r = -0,439, dan p<0,0001, r = -0,423), dan antara kadar feritin danhepsidin serum (p<0,001, r = 0,371). Dapat disimpulkan bahwa IRF memilikihubungan bermakna dengan status besi tubuh.
ABSTRACT
Decreased total body iron will cause iron deficiency, which could end up to irondeficiency anemia. Currently, immature reticulocyte fraction (IRF) wasintroduced as a parameter to show young reticulocyte fraction in the circulation,as a useful tool to evaluate erythropoiesis activity. The aim of this study was toinvestigate the correlation between IRF with serum iron and ferritinconcentrations, and with transferin saturation, and between serum ferritin withhepcidin concentration. A cross sectional study was conducted in Pramuka islandinvolving 77 post-menarchal adolescent school girls, who had received twiceweekly iron supplementation for 12 weeks. Serum concentrations of iron, ferritin,and hepsidin, haemoglobin concentration, transferin saturation, absolutereticulocyte count, and IRF were determined. There were significance correlationsbetween IRF with serum iron and ferritin, concentrations, and with transferinsaturation (p<0.0001, r = - 0.443; p<0.0001, r = -0.439 ; and p = <0.0001, r = -0.423, respectively), and between serum hepsidin and ferritin concentrations(p<0.001, r = 0.371). It can be concluded that IRF had significant correlation withiron status. |
T-Azma Rosida.pdf :: Unduh