Deskripsi Lengkap
| Bahasa : | ind |
| Sumber Pengatalogan : | |
| Tipe Konten : | |
| Tipe Media : | |
| Tipe Carrier : | |
| Deskripsi Fisik : | xiv, 39 hlm. ; 28 cm. + lamp. |
| Naskah Ringkas : | |
| Lembaga Pemilik : | Universitas Indonesia |
| Lokasi : | Perpustakaan UI, Lantai 3 |
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| No. Panggil | No. Barkod | Ketersediaan |
|---|---|---|
| S45349 | 14-20-544779095 | TERSEDIA |
| Tidak ada ulasan pada koleksi ini: 20330648 |
Abstrak
Latar belakang: Periodontitis adalah penyakit kronis terlokalisasi pada jaringan penyangga gigi. Penyebab penyakit ini multifaktorial, termasuk faktor genetik.
Tujuan: Menganalisis hubungan polimorfisme genetik IL-10 pada laki-laki terhadap derajat keparahan periodontitis.
Metode: Menggunakan tehnik PCR dan RFLP (enzim RSA I), dianalisis dengan elektroforesis dan divisualisasi menggunakan Gel Doc.
Hasil: 44 sampel normal terdapat genotip: CC 27,27%, CA 41,37%, AA 11,36%; 70 kelompok periodontitis : ringan CC 50%, CA 12,5%, AA 37,5%; sedang: CC 38,9%, CA 47,2%, AA 13,9%; berat: CC 42,3%, CA 30,8%, AA 19,4%.
Kesimpulan: Ditemukan gambaran polimorfisme IL-10 pada pada penelitian ini, namun tidak berhubungan dengan derajat keparahan periodontitis.(p>0.05).
Background: Periodontitis is a chronic disease localized to the supporting tissue and bone of teeth. It is multifactorial, including genetic factors. Aim: To analyze the relationship of genetic polymorphisms in the IL-10 men against the severity of periodontitis. Methods: Using PCR and RFLP techniques (RSA enzyme I), were analyzed by electrophoresis and visualized using the Gel Doc. Results: 44 normal samples contained genotypes: CC 27.27%, 41.37% CA, AA 11.36%; 70 samples of periodontitis: a light CC 50%, CA 12.5% ??AA 37.5%; were: CC 38.9%, CA 47.2%, AA 13.9%, by weight: 42.3% CC, CA 30.8%, 19.4% AA. Conclusion: We found the distribution of the IL-10 genetic polymorphism in the normal group and periodontitis groups, but not related to the severity of periodontitis. (P> 0.05).
Background: Periodontitis is a chronic disease localized to the supporting tissue and bone of teeth. It is multifactorial, including genetic factors. Aim: To analyze the relationship of genetic polymorphisms in the IL-10 men against the severity of periodontitis. Methods: Using PCR and RFLP techniques (RSA enzyme I), were analyzed by electrophoresis and visualized using the Gel Doc. Results: 44 normal samples contained genotypes: CC 27.27%, 41.37% CA, AA 11.36%; 70 samples of periodontitis: a light CC 50%, CA 12.5% ??AA 37.5%; were: CC 38.9%, CA 47.2%, AA 13.9%, by weight: 42.3% CC, CA 30.8%, 19.4% AA. Conclusion: We found the distribution of the IL-10 genetic polymorphism in the normal group and periodontitis groups, but not related to the severity of periodontitis. (P> 0.05).