Construction of recombinant plasmid pcDNA3.1/BMP-2 and its involvement in differentiation of human dental pulp-derived cells into an odontoblastic lineage / Hedijanti Joenoes, Mindia Yuniastuti, Endang W., Bachtiar, Boy M. Bachtiar
Hedijanti Joenoes
([Fakultas Kedokteran Gigi Universitas Indonesia, Fakultas Kedokteran Gigi Universitas Indonesia], 2009)
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Experimental studies have shown that dental pulp tissue has potential to regenerate dentine in response to adversestimuli, such as caries and associated operative procedures. However, the potential of dental pulp regeneration seems tobe limited by regenerative capacity of the cell involved. In this study, we report the effect of transfection of arecombinant plasmid containing human BMP-2 gene in proliferation and differentiation of dental pulp tissue in vitro.The regenerative capacity was analyzed by ALP production and calcium content. Results showed that the transfecteddental pulp cell was able to differentiate into the odontoblast phenotype, indicating the presence of odontoblastprogentitor cells in dental pulp tissue. |
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Penerbitan : | [Place of publication not identified]: [Fakultas Kedokteran Gigi Universitas Indonesia, Fakultas Kedokteran Gigi Universitas Indonesia], 2009 |
Sumber Pengatalogan : | LibUI eng rda |
ISSN : | 23563656 |
Majalah/Jurnal : | Makara Journal of Health Research |
Volume : | Vol. 13, No. 1, Juni 2009: Hal. : 5-8 |
Tipe Konten : | text |
Tipe Media : | computer |
Tipe Carrier : | online resource |
Akses Elektronik : | http://journal.ui.ac.id/index.php/health/article/view/327/323 |
Institusi Pemilik : | Universitas Indonesia |
Lokasi : | Direktorat Riset dan Pengabdian Masyarakat UI |
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