Latar belakang: Berbagai studi menunjukkan pasien kusta memiliki status zinc yang rendah. Namun status zinc pada narakontak kusta, yang ditentukan dengan kadar IgM anti-PGL1, belum diketahui. Tujuan penelitian ini untuk mengetahui hubungan antara kadar zinc plasma dengan IgM anti-PGL-1 pada narakontak kusta.Metode: Penelitian ini merupakan studi observasi. Subjek penelitian terdiri dari 186 narakontak kusta. Pengukuran status plasma zinc menggunakan atomic absorption spectrophotometer sedangkan pemeriksaan kadar IgM anti-PGL1 level menggunakan ELISA (Polyclonal rabbit anti human IgM/HRP/(Dako®).Hasil: Kadar rata-rata IgM anti-PGL1 subjek adalah 804 unit/mL (± 439,4) dan kadar rata-rata plasma zinc adalah 16,6 μmol/L (± 3,5). Ada hubungan yang signifikan antara kadar plasma zinc dengan IgM anti-PGL1 (r = - 0,230; p =0,002).Kesimpulan: Terdapat hubungan yang bermakna antara kadar plasma zinc dengan IgM anti-PGL1 pada nara kontak.
Abstract
Background: Previous study showed leprosy patients have low zinc status. Yet the status of zinc in close-contact, which indicated by IgM anti-PGL1 level, have not determined. The aim of the study was to determine the association of zinc plasma and IgM anti-PGL-1 levels among close contact of leprosy patients in Indonesia.Methods: This was an observational study. Subjects were 186 close-contact leprosy patients. Measurement of zinc plasma status used atomic absorption spectrophotometer while examination of IgM anti-PGL1 level used ELISA (Polyclonal rabbit anti human IgM/HRP/(Dako®).Results: The average level of IgM anti-PGL1 and zinc plasma were 804 unit/mL (± 439.4) and 16.6 μmol/L (± 3.5) consecutively. There was significant correlation between zinc plasma and IgM anti-PGL1 (r = - 0.230; p = 0.002).Conclusion: There is a significant correlation between zinc plasma and IgM anti-PGL1 in close contact of leprosy |
