ABSTRAK
Prevalensi penyakit kardiovaskuler (PKV) meningkat seiring dengan prosespenuaan. Aterosklerosis yang menyebabkan terjadinya inflamasi dan diikutipeningkatan kadar C-reactive protein (CRP). Vitamin D merupakan vitamin yangmemiliki efek antiinflamasi dan dapat menurunkan kadar hsCRP. Penelitian inimerupakan penelitian dengan desain potong lintang yang bertujuan untukmengetahui korelasi antara kadar vitamin D dengan kadar hsCRP pada usia lanjut(usila). Penelitian dilakukan di Pusat Santunan Keluarga (Pusaka) 12 di Tomangdan Pusaka 39 di Senen pada pertengahan bulan Desember 2012 sampai bulanJanuari 2013. Pengambilan subyek dilakukan dengan cara cluster randomsampling, dan didapatkan 71 orang subyek yang memenuhi kriteria penelitian.Data dikumpulkan melalui wawancara meliputi data usia, asupan vitamin Ddengan metode Food Frequency Questionnaire (FFQ) semikuantitatif serta totalskor pajanan sinar matahari mingguan. Pengukuran antropometri untuk menilaistatus gizi dan pemeriksaan laboratorium yang meliputi kadar vitamin D danhsCRP. Didapatkan median usia 69 (60-85) tahun dan 80,3% subyek adalahperempuan. Malnutrisi terdapat pada 71,8 % subyek. Asupan vitamin Dmenunjukkan 98,6% subyek memiliki asupan vitamin D kurang dari AngkaKecukupan Gizi (AKG) Indonesia. Sebanyak 97,2% subyek memiliki skorpajanan sinar matahari rendah. Nilai rerata kadar vitamin D 38,02±12,94 nmol/Ldan 78% subyek tergolong defisiensi vitamin D. Nilai median kadar hsCRP 1,5(0,1-49,6) mg/L, dan 67,6% subyek tergolong risiko PKV sedang dan tinggi.Didapatkan korelasi positif tidak bermakna antara kadar vitamin D serum dengankadar hsCRP pada usila (r=0,168, p=0,162).
ABSTRACT
The prevalence of cardiovascular disease (CVD) increases in the elderly.Atherosclerosis is a major cause of CVD which stimulate inflammation andfollowed by increase production of C-reactive protein (CRP). Vitamin D is avitamin which has anti-inflammatory effects and may reduce level of hsCRP. Theaim of this cross sectional study was to find the correlation between serumvitamin D level and hsCRP in elderly. Data collection was conducted duringDecember 2012 to January 2013 on 2 selected Pusaka, Pusaka 12 (Tomang) andPusaka 39 (Senen). Subjects were obtained using cluster random samplingmethod. A total of 71 elderly subjects had met the study criteria. Data werecollected through interviews including age, vitamin D intake and weekly score ofsunlight exposure. Anthropometry measurements to assess the nutritional statusand laboratory examination i.e blood levels of vitamin D and hsCRP. Majority ofthe subjects were female (80,3%), median age was 69 (60-85) years. Malnutritionwas occured in 71.8% of the subjects. Intake of vitamin D showed 98.6% of thesubjects were less than recommended dietary allowances (RDA). Majority of thesubjects had low score of sunlight exposure (97,2%). Mean of vitamin D levels38,02±12,94 nmol/L, while 78% the of subjects were categorized as vitamin Ddeficiency. Median of hsCRP levels 1,5 (0,1-49,6) mg/L, while 67,6% subjectswere at moderate and high risk of CVD. No significant correlation was foundbetween serum vitamin D levels and hsCRP levels (r=0,168, p=0,162). |
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