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Korelasi antara kadar vitamin D serum dengan kadar hsCRP pada usia lanjut = Correlation between serum vitamin D level and hsCRP in elderly / Audrey Haryanto

Audrey Haryanto; Savitri Sayogo, supervisor; Arya Govinda Rooshoeroe, supervisor; Drupadi H.S. Dillon, supervisor; Ninik Mudjihartini, examiner; Edy Rizal Wahyudi, examiner; Zarni Amri, examiner ([Publisher not identified] , 2013)

 Abstrak

ABSTRAK
Prevalensi penyakit kardiovaskuler (PKV) meningkat seiring dengan proses
penuaan. Aterosklerosis yang menyebabkan terjadinya inflamasi dan diikuti
peningkatan kadar C-reactive protein (CRP). Vitamin D merupakan vitamin yang
memiliki efek antiinflamasi dan dapat menurunkan kadar hsCRP. Penelitian ini
merupakan penelitian dengan desain potong lintang yang bertujuan untuk
mengetahui korelasi antara kadar vitamin D dengan kadar hsCRP pada usia lanjut
(usila). Penelitian dilakukan di Pusat Santunan Keluarga (Pusaka) 12 di Tomang
dan Pusaka 39 di Senen pada pertengahan bulan Desember 2012 sampai bulan
Januari 2013. Pengambilan subyek dilakukan dengan cara cluster random
sampling, dan didapatkan 71 orang subyek yang memenuhi kriteria penelitian.
Data dikumpulkan melalui wawancara meliputi data usia, asupan vitamin D
dengan metode Food Frequency Questionnaire (FFQ) semikuantitatif serta total
skor pajanan sinar matahari mingguan. Pengukuran antropometri untuk menilai
status gizi dan pemeriksaan laboratorium yang meliputi kadar vitamin D dan
hsCRP. Didapatkan median usia 69 (60-85) tahun dan 80,3% subyek adalah
perempuan. Malnutrisi terdapat pada 71,8 % subyek. Asupan vitamin D
menunjukkan 98,6% subyek memiliki asupan vitamin D kurang dari Angka
Kecukupan Gizi (AKG) Indonesia. Sebanyak 97,2% subyek memiliki skor
pajanan sinar matahari rendah. Nilai rerata kadar vitamin D 38,02±12,94 nmol/L
dan 78% subyek tergolong defisiensi vitamin D. Nilai median kadar hsCRP 1,5
(0,1-49,6) mg/L, dan 67,6% subyek tergolong risiko PKV sedang dan tinggi.
Didapatkan korelasi positif tidak bermakna antara kadar vitamin D serum dengan
kadar hsCRP pada usila (r=0,168, p=0,162).

ABSTRACT
The prevalence of cardiovascular disease (CVD) increases in the elderly.
Atherosclerosis is a major cause of CVD which stimulate inflammation and
followed by increase production of C-reactive protein (CRP). Vitamin D is a
vitamin which has anti-inflammatory effects and may reduce level of hsCRP. The
aim of this cross sectional study was to find the correlation between serum
vitamin D level and hsCRP in elderly. Data collection was conducted during
December 2012 to January 2013 on 2 selected Pusaka, Pusaka 12 (Tomang) and
Pusaka 39 (Senen). Subjects were obtained using cluster random sampling
method. A total of 71 elderly subjects had met the study criteria. Data were
collected through interviews including age, vitamin D intake and weekly score of
sunlight exposure. Anthropometry measurements to assess the nutritional status
and laboratory examination i.e blood levels of vitamin D and hsCRP. Majority of
the subjects were female (80,3%), median age was 69 (60-85) years. Malnutrition
was occured in 71.8% of the subjects. Intake of vitamin D showed 98.6% of the
subjects were less than recommended dietary allowances (RDA). Majority of the
subjects had low score of sunlight exposure (97,2%). Mean of vitamin D levels
38,02±12,94 nmol/L, while 78% the of subjects were categorized as vitamin D
deficiency. Median of hsCRP levels 1,5 (0,1-49,6) mg/L, while 67,6% subjects
were at moderate and high risk of CVD. No significant correlation was found
between serum vitamin D levels and hsCRP levels (r=0,168, p=0,162).

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Subjek :
Penerbitan : [Place of publication not identified]: [Publisher not identified], 2013
Program Studi :
Bahasa : ind
Sumber Pengatalogan : LibUI ind rda
Tipe Konten : text
Tipe Media : computer
Tipe Carrier : online resource
Deskripsi Fisik : xvi, 117 pages : illustration ; 28 cm + appendix
Naskah Ringkas :
Lembaga Pemilik : Universitas Indonesia
Lokasi : Perpustakaan UI, Lantai 3
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