Abstrak
Latar belakang: Suatu biomarker imunologis diperlukan untuk kasus yang berbatasan antara periodontitis kronis dan periodontitis agresif. Matrix Metalloproteinase-8 (MMP-8) merupakan suatu biomarker penentu risiko dan derajat keparahan penyakit periodonal serta evaluasi hasil perawatan periodontal.
Tujuan: Menganalisis kadar MMP-8 pada cairan krevikular gingiva penderita periodontitis kronis dan periodontitis agresif.
Metode: Penelitian ini mencakup 12 pasien periodontitis agresif, 17 pasien periodontitis kronis dan 6 subjek sehat. Kadar MMP-8 diukur dengan teknik ELISA.
Hasil: Kadar MMP-8 pada periodonitits kronis tidak berbeda bermakna dengan periodontitis agresif (p>0,05).
Kesimpulan: MMP-8 tidak dapat digunakan sebagai acuan diagnosis.
......Background: An immunologic biomarker is needed to distinguish between borderline cases between chronic periodontitis and agressive periodontitis. Matrix Metalloproteinase-8 (MMP-8) can be a risk profile of periodontal disease, disease progression and evaluation of periodontal treatment.
Aim: Analyze MMP-8 levels in gingival crevicular fluid of chronic and aggressive periodontitis patients.
Method: Sampel was collected from 6 healthy subjects, 12 subjects aggressive periodontitis and 17 chronic periodontitis subjects. MMP-8 levels were measured with ELISA.
Result:MMP-8 levels in chronic periodontitis did not show any difference to the MMP-8levels in aggressive periodonitits (p>0,05).
Conclusion: MMP-8 can not serve as a diagnostic parameter.
