|
[Latar Belakang. Disfungsi endotel dan aterosklerosis merupakan kondisi yangterjadi secara sistemik. Bila ada aterosklerosis di aorta, maka kemungkinan jugaterjadi aterosklerosis di arteri koroner. Kekakuan aorta akibat aterosklerosistersebut dapat diketahui dari pulse wave velocity (PWV) aorta. Penelitian ini akanmenilai hubungan antara PWV aorta dengan keberadaan penyakit arteri koroner(PAK) berdasarkan skor SYNTAX (Synergy between percutaneous coronaryintervention with Taxus and cardiac surgery) angiografi koroner.Metode. Penelitian ini merupakan suatu penelitian observasional potong lintang.Evaluasi dilakukan pada 83 pasien yang menjalani angiografi koroner elektif diPusat Jantung Nasional harapan Kita dan memenuhi kriteria inklusi sejakSeptember hingga November 2013. Hubungan nilai PWV aorta dengankeberadaan PAK berdasarkan skor SYNTAX dinilai dengan analisis regresilogistik.Hasil. Setelah disesuaikan dengan usia, jenis kelamin, indeks massa tubuh,hipertensi, diabetes melitus, dislipidemia, penghambat enzim konvertingangiotensin, penyekat reseptor angiotensin, penyekat kanal kalsium, diuretik, danpasca infark miokard, tidak ditemukan hubungan antara PWV aorta dengankeberadaan PAK (Odds ratio 2,126; IK 95%: 0,744 – 6,072; p= 0,159). Padakelompok PAK tidak ditemukan korelasi antara nilai PWV aorta dengan skorSYNTAX (r= -0,082; p= 0,539). Uji regresi logistik multinomial antara PWVaorta dengan skor pembuluh juga tidak menunjukkan hubungan yang bermakna.Kesimpulan. PWV aorta tidak memiliki hubungan yang bermakna dengankeberadaan dan beratnya stenosis PAK, tetapi pada kelompok PAK adakecenderungan terjadi PWV aorta lebih tinggi., Background. Endothelial dysfunction and atherosclerosis are conditions thatoccurs systemically. If atherosclerosis occurred in the aorta, it may also occurredatherosclerosis in coronary artery. Aortic stiffness as a result of atherosclerosiscan be known from the pulse wave velocity (PWV) of the aorta. This study willassess the relationship between aortic PWV with the presence of coronary arterydisease (CAD) by SYNTAX (Synergy between percutaneous coronaryintervention with TAXUS and cardiac surgery) score from coronary angiography.Method. This study is a cross-sectional observational study. The evaluation wasdone on 83 patients who undergoing elective coronary angiography at theHarapan Kita National Heart Centre and met the inclusion criteria sinceSeptember to November 2013. The relationship between aortic PWV values withthe presence of CAD by SYNTAX score was assessed by logistic regressionanalysis.Results. After adjusting for age, sex, body mass index, hypertension, diabetesmellitus, dyslipidemia, angiotensin converting enzym inhibitor, angiotensinreseptor blocker, calcium channel blocker, diuretic, and post myocardialinfarction, analyses revealed there is no associated between aortic PWV with thepresence of CAD (Odds ratio 2,126; IK 95%: 0,744 – 6,072; p= 0,159). In CADgroup, there was no associated between aortic PWV value with SYNTAX score.After multinomial logistic regression between aortic PWV with vessel score, thereis also no significantly associated.Conclusion. Aortic PWV has no relation with the presence and severity of CAD,but there is a trend toward high aortic PWV in CAD group.] |
SP-Heru Sulastomo.pdf :: Unduh