Respons terapi empiris pada pasien HIV-AIDS yang diduga ensefalitis toksoplasma di RSCM dan faktor yang mempengaruhi = Response to empirical therapy in AIDS patients with suspected toxoplasma encephalitis in Cipto Mangunkusumo Hospital and the influencing factors
Donna Octaviani;
(Fakultas Kedokteran Universitas Indonesia, 2013)
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[Latar Belakang: Ensefalitis toksoplasma (ET) termasuk infeksi oportunistik yangpaling banyak menyebabkan penyakit SSP pasien AIDS. Algoritma penatalaksanaanlesi fokal otak ET pasien AIDS di Rumah Sakit Cipto Mangunkusumo (RSCM)masih berdasarkan terapi empiris ET. Tujuan: Mengetahui proporsi pasien AIDSdiduga ET yang menunjukkan perbaikan klinis dan atau radiologis setelah diberikanterapi empiris dan faktor-faktor yang mempengaruhi. Metode: Studi retrospektifpotong lintang melalui data rekam medis pasien AIDS dewasa diduga klinis ET rawatinap pertama kali di RSCM dari tahun 2010-2012 dengan CD4 <200sel/mm3.Perbaikan klinis dan atau radiologis dinilai setelah 2 minggu terapi empiris. Hasil:Didapatkan 82 subyek, dengan perbaikan klinis pada 63 pasien (77%). Terdapat 20subyek yang menjalani pencitraan evaluasi dan dapat dibandingkan.Enam belas diantaranya didapatkan perbaikan radiologis. Median usia subyek 30 tahun (23-51) dannilai median CD4 21 sel/mm3 (3-152). Penyakit penyerta terbanyak adalahtuberkulosis (46.3%), pneumonia (40.2%), dan sepsis (22%). Subyek tanpa sepsismemberikan respons yang lebih baik secara nyata dibandingkan subyek dengan sepsis(p= 0,000). Kesimpulan: Pemberian terapi empiris pada pasien yang diduga ETsecara klinis masih menghasilkan respons klinis dan atau radiologis yang baik. Sepsismenurunkan secara bermakna respons terhadap terapi empiris.;Background: Toxoplasma encephalitis (TE) is one of opportunistic infections thatmost cause CNS disease in AIDS and leads to focal brain lesions. The algorithmmanagement of focal brain lesions AIDS patients in Cipto Mangunkusumo Hospital(RSCM) was based on empirical therapy of TE. Aim: To find out the proportion ofAIDS patients in RSCM with clinical diagnosis of TE who showed clinical and orradiological improvement after administration of empirical therapy and theinfluencing factors. Method: A retrospective, cross-sectional study using medicalrecords of adult AIDS patients admitted in RSCM from year 2010–2012. The eligiblesubjects were those who were admitted with clinical diagnosis of TE for the first timeand CD4 <200cells/mm3. Clinical and or radiological improvement was assessedafter two weeks of empirical therapy. Results: There were 82 eligible subjects.Clinical improvement was found in 63 subjects (77%). There were 20 subjects whoundergone serial neuroimaging examination and have comparable result. Sixteensubjects showed radiological improvement. Median age of the subjects was 30 yearsold (23–51) and median CD4 was 21cells/mm3 (3–152).The most frequentcomorbidities were tuberculosis (46.3%), pneumonia (40.2%), and sepsis(22%).Subjects without sepsis were more responsive to empirical therapy compared tosubjects with sepsis (p= 0.00).Conclusions: Administration of empirical therapy inpatients clinically diagnosed with TE provided favourable clinical and or radiologicalresponses. Sepsis was associated with poor response to empirical therapy., Background: Toxoplasma encephalitis (TE) is one of opportunistic infections thatmost cause CNS disease in AIDS and leads to focal brain lesions. The algorithmmanagement of focal brain lesions AIDS patients in Cipto Mangunkusumo Hospital(RSCM) was based on empirical therapy of TE. Aim: To find out the proportion ofAIDS patients in RSCM with clinical diagnosis of TE who showed clinical and orradiological improvement after administration of empirical therapy and theinfluencing factors. Method: A retrospective, cross-sectional study using medicalrecords of adult AIDS patients admitted in RSCM from year 2010–2012. The eligiblesubjects were those who were admitted with clinical diagnosis of TE for the first timeand CD4 <200cells/mm3. Clinical and or radiological improvement was assessedafter two weeks of empirical therapy. Results: There were 82 eligible subjects.Clinical improvement was found in 63 subjects (77%). There were 20 subjects whoundergone serial neuroimaging examination and have comparable result. Sixteensubjects showed radiological improvement. Median age of the subjects was 30 yearsold (23–51) and median CD4 was 21cells/mm3 (3–152).The most frequentcomorbidities were tuberculosis (46.3%), pneumonia (40.2%), and sepsis(22%).Subjects without sepsis were more responsive to empirical therapy compared tosubjects with sepsis (p= 0.00).Conclusions: Administration of empirical therapy inpatients clinically diagnosed with TE provided favourable clinical and or radiologicalresponses. Sepsis was associated with poor response to empirical therapy.] |
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No. Panggil : | T58579 |
Entri utama-Nama orang : | |
Subjek : | |
Penerbitan : | Jakarta: Fakultas Kedokteran Universitas Indonesia, 2013 |
Program Studi : |
Bahasa : | ind |
Sumber Pengatalogan : | LibUI ind rda |
Tipe Konten : | text |
Tipe Media : | unmediated ; computer |
Tipe Carrier : | volume ; online resource |
Deskripsi Fisik : | xvii, 65 hlm. ; 30 cm. + lamp. |
Naskah Ringkas : | |
Lembaga Pemilik : | Universitas Indonesia |
Lokasi : | Perpustakaan UI, Lantai 3 |
No. Panggil | No. Barkod | Ketersediaan |
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T58579 | 15-24-78966331 | TERSEDIA |
Ulasan: |
Tidak ada ulasan pada koleksi ini: 20367164 |