[Latar belakang: Neuropati perifer terinduksi kemoterapi (NPTK) merupakanefek samping kemoterapi neurotoksik yang menurunkan kualitas hidup penderitadan menghalangi pemberian kemoterapi yang optimal. Suatu alat skrining dengantingkat akurasi mendekati alat elektroneurografi (ENG) dibutuhkan untukmendeteksi NPTK secara dini. Skor Toronto clinical scoring system (TCSS)merupakan alat skrining sederhana dan terbukti unggul untuk pemeriksaanneuropati pada diabetes melitus (DM). Kesamaan gambaran klinis antaraneuropati DM dengan NPTK dapat menjadikan TCSS sebagai alat skrining untukNPTK.Tujuan: Mencari nilai ROC, senstivitas dan spesifisitas TCSS dibandingkandengan standar baku pemeriksaan ENGMetode penelitian: Penelitian berupa uji diagnostik skor TCSS pada penderitakeganasan yang mendapat kemoterapi cisplatin di poli hematoonkologi dan ruangperawatan kemoterapi RS Ciptomangunkusumo. Pemeriksaan ENG dan skorTCSS dilakukan pada setiap subjek. Hasil dianalisa untuk mendapatkan kurvaROC, sensitivitas dan spesifisitas.Hasil: Dari 77 subjek, terdapat 66 yang dapat dianalisa. Diagnosis polineuropatidengan menggunakan ENG sebanyak 34 (51,5%), begitu juga denganmenggunakan TCSS (51,5%). Komponen abnormal TCSS terbanyak adalahkomponen pemeriksaan refleks tendon (78,8%). Dari analisa uji diagnostikdidapatkan nilai AUC 75,4%, sensitivitas 79,4%, spesifisitas 59,4%, nilai prediksipositif 67,5% dan nilai prediksi negatif 73,1%, dengan titik potong optimal ≥ 5.Kesimpulan: Skor TCSS memiliki nilai diagnostik yang cukup baik sebagai alatskrining pada NPTK. Skor ini juga memiliki nilai titik potong optimal yang sesuaidengan karakteristik klinis NPTK dan komponen yang dapat digunakan untukmendeteksi gejala awal NPTK.;Background: Chemotherapy induced peripheral neuropathy (CIPN) is anadverse effect of neurotoxic chemotherapy that lower the patient’s quality of lifeand prevent optimal chemotherapy. Early detection by a screening tool that have anear accuracy to electroneurography (ENG) is needed. The Toronto clinicalscoring system (TCSS) is a simple and superior tool for screening diabeticneuropathy. Similarity between diabetic neuropathy and CIPN’s clinical picturecould make the TCSS as screening tool for CIPN.Purpose: to discover the ROC, sensitivity and specificity of TCSS compared tothe ENG as gold standardMethodology: the study is a diagnostic test of TCSS in cancer patients withcisplatin from Hematooncology clinic and chemotherapy ward of RSCM. ENGtest and TCSS examination were done for each subject. Results were analyzed forROC, sensitivity and specificity.Result: out of 77 subjects, only 66 were analyzed. CIPN were diagnosed in 34(51,5%) by ENG, and also in 34 (51,5%) by TCSS. The most abnormalcomponent of TCSS is the tendon reflex examination (78,8%). The diagnosticanalysis acquire the AUC 75,4%, 79,4% sensitivity, 59,4% specificity, positivepredictive value of 67,5% and negative predictive value of 73,1%. The optimalcut off point is ≥ 5.Conclusion: The TCSS is a passable screening tool for CIPN. It also have optimalcut-off point which resemble CIPN’s clinical characteristics and componentwhich can be use to detect early signs., Background: Chemotherapy induced peripheral neuropathy (CIPN) is anadverse effect of neurotoxic chemotherapy that lower the patient’s quality of lifeand prevent optimal chemotherapy. Early detection by a screening tool that have anear accuracy to electroneurography (ENG) is needed. The Toronto clinicalscoring system (TCSS) is a simple and superior tool for screening diabeticneuropathy. Similarity between diabetic neuropathy and CIPN’s clinical picturecould make the TCSS as screening tool for CIPN.Purpose: to discover the ROC, sensitivity and specificity of TCSS compared tothe ENG as gold standardMethodology: the study is a diagnostic test of TCSS in cancer patients withcisplatin from Hematooncology clinic and chemotherapy ward of RSCM. ENGtest and TCSS examination were done for each subject. Results were analyzed forROC, sensitivity and specificity.Result: out of 77 subjects, only 66 were analyzed. CIPN were diagnosed in 34(51,5%) by ENG, and also in 34 (51,5%) by TCSS. The most abnormalcomponent of TCSS is the tendon reflex examination (78,8%). The diagnosticanalysis acquire the AUC 75,4%, 79,4% sensitivity, 59,4% specificity, positivepredictive value of 67,5% and negative predictive value of 73,1%. The optimalcut off point is ≥ 5.Conclusion: The TCSS is a passable screening tool for CIPN. It also have optimalcut-off point which resemble CIPN’s clinical characteristics and componentwhich can be use to detect early signs.] |