[Pendahuluan - Kejang pascaoperasi merupakan salah satu komplikasi pascakraniotomitumor. Prevalensinya antara 4 – 20%, dan paling banyak muncul satuminggu pascaoperasi. Penambahan obat fenitoin pada pemberian obatlevetiracetam untuk mengendalikan kejang pascaoperasi belum pernah ditelilti.Tujuan - Untuk mengetahui apakah terdapat perbedaan antara kelompok yangmendapatkan levetiracetam dengan dan tanpa penambahan fenitoin dalam halkejadian kejang pascaoperasi, efek samping, peningkatan dosis steroid, sertagambaran faktor risiko kejang pascaoperasi. Metode - Penelitian ini merupakanpenelitian pendahuluan menggunakan metode uji klinis. Pasien dirandomisasi dandikelompokkan menjadi kelompok yang mendapatkan levetiracetam saja danlevetiracetam dengan fenitoin. Diobervasi selama 7 hari pascaoperasi, apakahterdapat kejang, efek samping, dan peningkatan dosis steroid. Pada kelompokyang mendapatkan fenitoin, kadar fenitoin dalam darah diukur pada hari ke-7.Hasil - Manfaat penambahan fenitoin pada pemberian levetiracetam masih belumbisa dinilai karena jumlah sampel masih sedikit. Efek samping lebih banyakditemukan pada kelompok yang mendapatkan penambahan fenitoin.;Introduction – Postoperative seizure is one of complications of brain tumorsurgery. Prevalence is 4-20% and mostly occurred in the first postoperative week.The beneficial of giving add on phenytoin to levetiracetam has never been studiedbefore. Aims – To determine the difference of postoperative seizure incidence,side effect, elevation of steroid dose, and risk factors profile in both groups, thelevetiracetam group and levetiracetam with add on phenytoin group. Methods –This is a pilot study with clinical trial design. Patients were randomized andallocated into two groups, levetiracetam group and levetiracetam with add onphenytoin group. Observation was done in 7 postoperative days. Any incidence ofpostoperative seizures, drug side effects, and elevation of steroid dose was noted.In group receiving phenyotin, the blood level of phenytoin was measured on the7th day. Result – The benefit of add on phenytoin to levetiracetam therapy forpostoperative seizure in brain tumor patients could not be evaluated due to smallsample size. More drug related side effects were found on group receivingphenytoin., Introduction – Postoperative seizure is one of complications of brain tumorsurgery. Prevalence is 4-20% and mostly occurred in the first postoperative week.The beneficial of giving add on phenytoin to levetiracetam has never been studiedbefore. Aims – To determine the difference of postoperative seizure incidence,side effect, elevation of steroid dose, and risk factors profile in both groups, thelevetiracetam group and levetiracetam with add on phenytoin group. Methods –This is a pilot study with clinical trial design. Patients were randomized andallocated into two groups, levetiracetam group and levetiracetam with add onphenytoin group. Observation was done in 7 postoperative days. Any incidence ofpostoperative seizures, drug side effects, and elevation of steroid dose was noted.In group receiving phenyotin, the blood level of phenytoin was measured on the7th day. Result – The benefit of add on phenytoin to levetiracetam therapy forpostoperative seizure in brain tumor patients could not be evaluated due to smallsample size. More drug related side effects were found on group receivingphenytoin.] |