Studi terakhir menunjukkan bahwa kulit bagian dalam durian (Durio zibethinus (Murr.)) yang terdiri dari mesocarp dan endocarp memiliki efek hepatoprotektif dan mengandung sejumlah senyawa bioaktif. Penelitian ini bertujuan untuk menguji efek antihiperlipidemia dari ekstrak etanol 70% kulit bagian dalam durian. Tiga puluh ekor tikus putih jantan galur Sprague dawley dan berat sekitar 200 gram dibagi dalam enam kelompok yang terdiri dari kontrol normal, kontrol perlakuan, kontrol pembanding, dan kelompok dosis 1, 2, serta 3. Kelompok kontrol normal hanya diberikan larutan CMC 0,5%. Kelompok kontrol perlakuan, kontrol pembanding, dan kelompok dosis 1, 2, serta 3 diberikan makanan tinggi kolesterol dan lemak. Setelah satu jam, berturut-turut diberikan CMC 0,5%, simvastatin 1,8 mg/200 g bb, ekstrak dengan dosis 36, 72, dan 144 mg/200 g bb. Setelah 56 hari, dilakukan pengambilan darah melalui sinus orbital dan penetapan kadar kolesterol total, trigliserida, HDL, dan LDL. Hasil penelitian menunjukkan bahwa ekstrak etanol 70% kulit bagian dalam durian (Durio zibethinus (Murr.)) memiliki efek antihiperlipidemia dengan dosis 36; 72; dan 144 mg/200 g bb terhadap tikus putih jantan ditinjau dari penurunan kadar kolesterol total, LDL, dan peningkatan HDL, tetapi penurunan kadar trigliserida hanya terjadi pada dosis 72 dan 144 mg/200 g bb.
The latest study showed that durian (Durio zibethinus (Murr.)) inner shell, which is consisted of mesocarp and endocarp, has a hepatoprotective effect and contains several kinds of bioactive compounds. This research aimed to observe antihyperlipidemic effect of 70% ethanol extract of durian inner shell. Thirty white male rats Sprague dawley strain with body weight 200 gram were divided into 6 groups, which are normal control, treatment control, comparator control, and dose group I, II, and III. Normal control group was only given 0.5% CMC solution. Treatment control, comparator control, and dose I, II, dan III groups were given high cholesterol and fat diet. After an hour, the following groups were given 0,5% CMC solution, simvastatin 1.8 mg/200 g bw, and extract 36; 72; and 144 mg/200 g bw. After 56 days, blood sampling was done through the orbital sinus and also the determination of total cholesterol, triglycerides, HDL, and LDL. The results showed that 70% ethanol extract of durian (Durio zibethinus (Murr.)) inner shell have an antihyperlipidemic effect at doses 36; 72; and 144 mg/200 g bw based on decreasing level of total cholesterol, LDL, and increasing level of HDL, yet decreasing level of triglyceride was only happened at doses 74 and 144 mg/200 g bw. |
S57359-Brillianty Shinta Devi.pdf :: Unduh