Sintesis dan uji sitotoksik l1210 senyawa 2 amino n fenil benzamida sebagai zat antara pembentukan senyawa 5h fenanthridin 6 on = Synthesis and cytotoxic activity l1210 of 2 amino n phenyl benzamide as intermediates in the synthesis of 5h phenanthridin 6 one

Boby Setiawan, author

Abstrak

[ABSTRAK

Telah dilakukan sintesis senyawa 2-amino-N-fenil benzamida yang merupakan zat antara pembentukan analog senyawa hasil isolasi 7-hidroksi-5H-fenanthridin-6-on (senyawa 5H- fenanthridin-6-on).

Sintesis senyawa 2-amino-N-fenil benzamida dilakukan melalui dua tahap reaksi, yaitu tahap pertama reaksi amidasi antara asam o-nitro benzoat dengan tionil klorida. Klorida asam yang terbentuk langsung direaksikan dengan anilin tanpa isolasi menghasilkan senyawa 2-nitro-N-fenil benzamida sebesar 84, 42 %. Reaksi tahap kedua dengan reduksi gugus nitro menjadi amina menggunakan Fe/HCl dilanjutkan netralisasi dengan basa menghasilkan senyawa 2-amino-N-fenil benzamida sebesar 79,01 %. Proses pemurnian hasil sintesis secara secara kromatografi kolom dan rekristalisasi serta diidentifikasi dengan menggunakan FT-IR dan LC-MS .

Uji aktivitas sitotoksik terhadap sel leukemia L1210 senyawa 2-nitro-N-fenil benzamida dan 2-amino-N-fenil benzamida, masing-masing mempunyai nilai IC50 sebesar 29,46 dan 26,90 g/ml.

ABSTRACT

Have performed the synthesis of 2-amino-N-phenyl benzamide (which is an intermediate formation of analog isolated compounds 7-hydroxy-5H-fenanthridin-6-one (compound 5H-fenanthridin-6-one).

Synthesis of 2-amino-N-phenyl benzamide done through a two-stage reaction, the first step amidation reaction between o-nitro benzoic acid with thionyl chloride. Chloride acid is formed directly without isolation was reacted with aniline to produce compounds 2-nitro-N-phenyl benzamide by 84, 42%. The second stage of the reduction reaction of nitro groups to amines using Fe/HCl followed by neutralization of alkaline compounds produce 2-amino-N-phenyl benzamide was 79.01%. The purification process results in the synthesis of recrystallization and column chromatography and identified using FT-IR and LC-MS.

Test cytotoxic activity against L1210 leukemia cells compound 2-nitro-N-phenyl benzamide and 2-amino-N-phenyl benzamide, each having an IC50 value of 29.46 and 26.90 g/ml.;Have performed the synthesis of 2-amino-N-phenyl benzamide (which is an intermediate formation of analog isolated compounds 7-hydroxy-5H-fenanthridin-6-one (compound 5H-fenanthridin-6-one).

Synthesis of 2-amino-N-phenyl benzamide done through a two-stage reaction, the first step amidation reaction between o-nitro benzoic acid with thionyl chloride. Chloride acid is formed directly without isolation was reacted with aniline to produce compounds 2-nitro-N-phenyl benzamide by 84, 42%. The second stage of the reduction reaction of nitro groups to amines using Fe/HCl followed by neutralization of alkaline compounds produce 2-amino-N-phenyl benzamide was 79.01%. The purification process results in the synthesis of recrystallization and column chromatography and identified using FT-IR and LC-MS.

Test cytotoxic activity against L1210 leukemia cells compound 2-nitro-N-phenyl benzamide and 2-amino-N-phenyl benzamide, each having an IC50 value of 29.46 and 26.90 g/ml., Have performed the synthesis of 2-amino-N-phenyl benzamide (which is an intermediate formation of analog isolated compounds 7-hydroxy-5H-fenanthridin-6-one (compound 5H-fenanthridin-6-one).

Synthesis of 2-amino-N-phenyl benzamide done through a two-stage reaction, the first step amidation reaction between o-nitro benzoic acid with thionyl chloride. Chloride acid is formed directly without isolation was reacted with aniline to produce compounds 2-nitro-N-phenyl benzamide by 84, 42%. The second stage of the reduction reaction of nitro groups to amines using Fe/HCl followed by neutralization of alkaline compounds produce 2-amino-N-phenyl benzamide was 79.01%. The purification process results in the synthesis of recrystallization and column chromatography and identified using FT-IR and LC-MS.

Test cytotoxic activity against L1210 leukemia cells compound 2-nitro-N-phenyl benzamide and 2-amino-N-phenyl benzamide, each having an IC50 value of 29.46 and 26.90 g/ml.]

File Digital: 1

Shelf

T41804-Boby Setiawan.pdf :: Unduh

LOGIN required

Kata Kunci

sintesis dan uji sitotoksik

l1210 senyawa 2-amino-n-fenil benzamida

pembentukan senyawa 5h-fenanthridin-6-on

Synthesis and cytotoxic

l1210 of 2 amino n phenyl benzamide

synthesis of 5h phenanthridin 6 one;

Metadata

No. Panggil :	T41804
Entri utama-Nama orang :	Boby Setiawan, author


Entri tambahan-Nama orang :	Emil Budianto, supervisor Muhammad Hanafi, supervisor Endang Saefudin, examiner Antonius Herry Cahyana, examiner
Entri tambahan-Nama badan :	Universitas Indonesia. Fakultas Matematika dan Ilmu Pengetahuan Alam

Subjek :	cytotoxicity, Immunologic
Penerbitan :	Depok: Fakultas Matematika dan Ilmu Pengetahuan Alam, 2014
Program Studi :	Ilmu Kimia

Bahasa :	ind
Sumber Pengatalogan :	LibUI ind rda
Tipe Konten :	text
Tipe Media :	unmediated ; computer
Tipe Carrier :	volume ; online resource
Deskripsi Fisik :	ix, 36 pages : illustration ; 28 cm + appendix
Naskah Ringkas :
Lembaga Pemilik :	Universitas Indonesia
Lokasi :	Perpustakaan UI, Lantai 3

:: UI - Tesis Membership :: Kembali