Sintesis dan uji sitotoksik l1210 senyawa 2 amino n fenil benzamida sebagai zat antara pembentukan senyawa 5h fenanthridin 6 on = Synthesis and cytotoxic activity l1210 of 2 amino n phenyl benzamide as intermediates in the synthesis of 5h phenanthridin 6 one
Boby Setiawan;
Emil Budianto, supervisor; Muhammad Hanafi, supervisor; Endang Saefudin, examiner; Antonius Herry Cahyana, examiner
(Fakultas Matematika dan Ilmu Pengetahuan Alam, 2014)
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[ABSTRAK Telah dilakukan sintesis senyawa 2-amino-N-fenil benzamida yang merupakan zat antara pembentukan analog senyawa hasil isolasi 7-hidroksi-5H-fenanthridin-6-on (senyawa 5H- fenanthridin-6-on).Sintesis senyawa 2-amino-N-fenil benzamida dilakukan melalui dua tahap reaksi, yaitu tahap pertama reaksi amidasi antara asam o-nitro benzoat dengan tionil klorida. Klorida asam yang terbentuk langsung direaksikan dengan anilin tanpa isolasi menghasilkan senyawa 2-nitro-N-fenil benzamida sebesar 84, 42 %. Reaksi tahap kedua dengan reduksi gugus nitro menjadi amina menggunakan Fe/HCl dilanjutkan netralisasi dengan basa menghasilkan senyawa 2-amino-N-fenil benzamida sebesar 79,01 %. Proses pemurnian hasil sintesis secara secara kromatografi kolom dan rekristalisasi serta diidentifikasi dengan menggunakan FT-IR dan LC-MS .Uji aktivitas sitotoksik terhadap sel leukemia L1210 senyawa 2-nitro-N-fenil benzamida dan 2-amino-N-fenil benzamida, masing-masing mempunyai nilai IC50 sebesar 29,46 dan 26,90 g/ml. ABSTRACT Have performed the synthesis of 2-amino-N-phenyl benzamide (which is an intermediate formation of analog isolated compounds 7-hydroxy-5H-fenanthridin-6-one (compound 5H-fenanthridin-6-one).Synthesis of 2-amino-N-phenyl benzamide done through a two-stage reaction, the first step amidation reaction between o-nitro benzoic acid with thionyl chloride. Chloride acid is formed directly without isolation was reacted with aniline to produce compounds 2-nitro-N-phenyl benzamide by 84, 42%. The second stage of the reduction reaction of nitro groups to amines using Fe/HCl followed by neutralization of alkaline compounds produce 2-amino-N-phenyl benzamide was 79.01%. The purification process results in the synthesis of recrystallization and column chromatography and identified using FT-IR and LC-MS.Test cytotoxic activity against L1210 leukemia cells compound 2-nitro-N-phenyl benzamide and 2-amino-N-phenyl benzamide, each having an IC50 value of 29.46 and 26.90 g/ml.;Have performed the synthesis of 2-amino-N-phenyl benzamide (which is an intermediate formation of analog isolated compounds 7-hydroxy-5H-fenanthridin-6-one (compound 5H-fenanthridin-6-one).Synthesis of 2-amino-N-phenyl benzamide done through a two-stage reaction, the first step amidation reaction between o-nitro benzoic acid with thionyl chloride. Chloride acid is formed directly without isolation was reacted with aniline to produce compounds 2-nitro-N-phenyl benzamide by 84, 42%. The second stage of the reduction reaction of nitro groups to amines using Fe/HCl followed by neutralization of alkaline compounds produce 2-amino-N-phenyl benzamide was 79.01%. The purification process results in the synthesis of recrystallization and column chromatography and identified using FT-IR and LC-MS.Test cytotoxic activity against L1210 leukemia cells compound 2-nitro-N-phenyl benzamide and 2-amino-N-phenyl benzamide, each having an IC50 value of 29.46 and 26.90 g/ml., Have performed the synthesis of 2-amino-N-phenyl benzamide (which is an intermediate formation of analog isolated compounds 7-hydroxy-5H-fenanthridin-6-one (compound 5H-fenanthridin-6-one).Synthesis of 2-amino-N-phenyl benzamide done through a two-stage reaction, the first step amidation reaction between o-nitro benzoic acid with thionyl chloride. Chloride acid is formed directly without isolation was reacted with aniline to produce compounds 2-nitro-N-phenyl benzamide by 84, 42%. The second stage of the reduction reaction of nitro groups to amines using Fe/HCl followed by neutralization of alkaline compounds produce 2-amino-N-phenyl benzamide was 79.01%. The purification process results in the synthesis of recrystallization and column chromatography and identified using FT-IR and LC-MS.Test cytotoxic activity against L1210 leukemia cells compound 2-nitro-N-phenyl benzamide and 2-amino-N-phenyl benzamide, each having an IC50 value of 29.46 and 26.90 g/ml.] |
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No. Panggil : | T41804 |
Entri utama-Nama orang : | |
Entri tambahan-Nama orang : | |
Entri tambahan-Nama badan : | |
Subjek : | |
Penerbitan : | Depok: Fakultas Matematika dan Ilmu Pengetahuan Alam, 2014 |
Program Studi : |
Bahasa : | ind |
Sumber Pengatalogan : | LibUI ind rda |
Tipe Konten : | text |
Tipe Media : | unmediated ; computer |
Tipe Carrier : | volume ; online resource |
Deskripsi Fisik : | ix, 36 pages : illustration ; 28 cm + appendix |
Naskah Ringkas : | |
Lembaga Pemilik : | Universitas Indonesia |
Lokasi : | Perpustakaan UI, Lantai 3 |
No. Panggil | No. Barkod | Ketersediaan |
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T41804 | 15-17-382598403 | TERSEDIA |
Ulasan: |
Tidak ada ulasan pada koleksi ini: 20389374 |