[ABSTRAK
Latar BelakangJaringan adiposa epikardial (JAE) sebagai jaringan adiposa visera penting peranannyadalam proses aterosklerosis di arteri koroner. Studi sebelumnya menunjukkan ketebalanadiposa epikardial lebih besar pada pasien dengan penyakit jantung koroner (PJK)TujuanMengetahui korelasi antara ketebalan adiposa epikardial dengan derajat stenosis arterikoroner pada pasien PJK stabilMetodeDilakukan studi potong lintang pada tujuh puluh pasien PJK stabil yang menjalaniangiografi koroner. Derajat stenosis arteri koroner dinilai dengan skor Gensini > 40(berat) dan ≤ 40 (ringan-sedang). Ketebalan adiposa epikardial dinilai denganekokardiografi transtorakal pada fase sistolik akhir tampilan parasternal long axis.HasilNilai rerata ketebalan adiposa epikardial adalah 5,96 mm (SB 1,76) dan nilai medianskor Gensini adalah 35,0 (kisaran 2-126). Analisis bivariat menunjukkan korelasi positifkuat yang bermakna (r = 0,768, p < 0,001). Nilai titik potong terbaik dari ketebalanadiposa epikardial yang memiliki nilai klinis berkaitan dengan derajat stenosis arterikoroner berdasarkan skor Gensini adalah 6,15 mm dengan sensitivitas 85,29%,spesifisitas 83,33%, nilai duga positif 82%, nilai duga negatif 85% dengan AUC sebesar0,893 (IK 95% 0,814-0,971, p < 0,001).SimpulanKetebalan adiposa epikardial berkorelasi signifikan dengan derajat stenosis arterikoroner berdasarkan skor Gensini. Ketebalan adiposa epikardial 6,15 mm memilikikemampuan yang cukup baik untuk membedakan pasien PJK stabil ringan-sedang danberat berdasarkan skor gensini.
ABSTRACT
Background:Epicardial adipose tissue (EAT) as part of visceral adipose tissue, has an integral role inthe atherosclerotic cardiovascular disease. Previous studies have shown that EAT isthicker in those with coronary heart disease.Objective:To determine the correlation of epicardial adipose thickness with the severity ofcoronary artery stenosis in stable coronary heart disease (CHD) patientMethod:A cross-sectional study was conducted on seventy stable CHD patient undergoingcoronary angiography. Severity of coronary artery stenosis was evaluated using Gensiniscoring system : > 40 (severe) and ≤ 40 (mild-moderate). Epicardial adipose tissue wasmeasured using transthoracic echocardiography at end-systole from parasternal longaxisview.Results :Mean value of epicardial adipose thickness was 5,96 mm (SD 1,76) and median valueof Gensini score was 35,0 (range 2-126). The correlation test showed a significantstrong-positive correlation (r = 0,768, p < 0,001). The best cut-off point of epicardialadipose thickness which has a clinical value correlating to severity of coronary arterystenosis based on Gensini scoring system was 6,15 mm with the sensitivity 85,29 %,specificity 83,33%, positive predictive value 82 %, negative predictive value 85 % andAUC of 0,893 (CI 0,814-0,971, p < 0,001)Conclusion :Epicardial fat thickness is significantly correlated to the severity of coronary arterystenosis based on Gensini scoring system. The thickness cutoff point of 6,15 mm has agood capability in discriminating mild-moderate dan severe stable CHD patient basedon Gensini scoring system;Background:Epicardial adipose tissue (EAT) as part of visceral adipose tissue, has an integral role inthe atherosclerotic cardiovascular disease. Previous studies have shown that EAT isthicker in those with coronary heart disease.Objective:To determine the correlation of epicardial adipose thickness with the severity ofcoronary artery stenosis in stable coronary heart disease (CHD) patientMethod:A cross-sectional study was conducted on seventy stable CHD patient undergoingcoronary angiography. Severity of coronary artery stenosis was evaluated using Gensiniscoring system : > 40 (severe) and ≤ 40 (mild-moderate). Epicardial adipose tissue wasmeasured using transthoracic echocardiography at end-systole from parasternal longaxisview.Results :Mean value of epicardial adipose thickness was 5,96 mm (SD 1,76) and median valueof Gensini score was 35,0 (range 2-126). The correlation test showed a significantstrong-positive correlation (r = 0,768, p < 0,001). The best cut-off point of epicardialadipose thickness which has a clinical value correlating to severity of coronary arterystenosis based on Gensini scoring system was 6,15 mm with the sensitivity 85,29 %,specificity 83,33%, positive predictive value 82 %, negative predictive value 85 % andAUC of 0,893 (CI 0,814-0,971, p < 0,001)Conclusion :Epicardial fat thickness is significantly correlated to the severity of coronary arterystenosis based on Gensini scoring system. The thickness cutoff point of 6,15 mm has agood capability in discriminating mild-moderate dan severe stable CHD patient basedon Gensini scoring system, Background:Epicardial adipose tissue (EAT) as part of visceral adipose tissue, has an integral role inthe atherosclerotic cardiovascular disease. Previous studies have shown that EAT isthicker in those with coronary heart disease.Objective:To determine the correlation of epicardial adipose thickness with the severity ofcoronary artery stenosis in stable coronary heart disease (CHD) patientMethod:A cross-sectional study was conducted on seventy stable CHD patient undergoingcoronary angiography. Severity of coronary artery stenosis was evaluated using Gensiniscoring system : > 40 (severe) and ≤ 40 (mild-moderate). Epicardial adipose tissue wasmeasured using transthoracic echocardiography at end-systole from parasternal longaxisview.Results :Mean value of epicardial adipose thickness was 5,96 mm (SD 1,76) and median valueof Gensini score was 35,0 (range 2-126). The correlation test showed a significantstrong-positive correlation (r = 0,768, p < 0,001). The best cut-off point of epicardialadipose thickness which has a clinical value correlating to severity of coronary arterystenosis based on Gensini scoring system was 6,15 mm with the sensitivity 85,29 %,specificity 83,33%, positive predictive value 82 %, negative predictive value 85 % andAUC of 0,893 (CI 0,814-0,971, p < 0,001)Conclusion :Epicardial fat thickness is significantly correlated to the severity of coronary arterystenosis based on Gensini scoring system. The thickness cutoff point of 6,15 mm has agood capability in discriminating mild-moderate dan severe stable CHD patient basedon Gensini scoring system] |
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