[Latar belakang: Hipertensi akan meningkatkan kadar asam urat yang akan memperburuk terjadinya Major Adverse Cardiac Events (MACE) pada penderita sindroma koroner akut (SKA). Dengan mengetahui kadar asam urat maka kita memprediksi terjadinya MACE sehingga dapat melakukan tata laksana SKA yang lebih optimal. Metode: Penelitian diakukan secara kohort retrospektif dengan menggunakan analisa kesintasan MACE selama tujuh hari pada penderita hipertensi yang mengalami SKA. Data diambil melalui rekam medis ICCU RSCM selama 2009-2013 secara konsekutif. Analisa data menggunakan kurva Kaplan Meir, Cox proportional hazard regression, analisis multivariat Cox proportional hazard regression Hasil Penelitian: Dua ratus lima puluh subyek penelitian dibagi dalam dua kelompok hiperurisemia dan tanpa hiperurisemia. MACE lebih banyak terjadi pada kelompok hiperurisemia yaitu 38 pasien dari 125 pasien (30.4%) dibandingkan tanpa hiperurisemia sebesar 16 pasien dari 125 pasien (12.8%). Analisa kesintasan mendapatkan MACE lebih cepat dan bermakna pada penderita hiperurisemia (P<0.001). Analisa Cox proportional hazard regression mendapatkan hasil hazard ratio sebesar 1.676 (IK95% 1.243-2.260). Analisa multivariat mendapatkan adjusted hazard ratio tidak berbeda bermakna pada variabel-variabel karakteristik dasar yang inhomogen yaitu variabel gagal jantung, ejeksi fraksi ventrikel kiri dan gangguan fungsi ginjal. Simpulan: Terdapat perbedaan kesintasan terjadinya MACE selama tujuh hari pada hipertensi yang mengalami SKA dengan hiperurisemia dan kelompok tanpa hiperurisemia dengan Hazard Ratio sebesar 1,676.
Background: Hypertension has strong correlation with uric acid levels. Many studies shows that hyperuricemia make worse major adverse cardiac events (MACE) in acute coronary syndrome patients. This study wants to assess the clinical value of hyperuricemia to make major adverse cardiac events in seven days in hypertension patients with acute coronary syndrome Methods: This is a retrospective cohort study by using medical record in intensive care coronary unit RSCM hospital. We evaluated two hundred fifty consecutive inpatients who were hospitalized by acute coronary syndrome with hypertension from 2009 to 2014. Data were analized with Kaplan Meir curved, Cox proportional hazard regression, Cox proportional hazard regression multivariate analysis. Results: Incidence of MACE in hyperuremic patients were 38 from 125 patients (30.4%) and no hyperuricemic patients were 16 from 125 patients (12.8%). Hyperuricemia was associated higher incidence of MACE with hazard ratio 1.676 (CI 1.254-2.260). After adjustment comorbid factors which are inhomogeneity in baseline characteristics for acute heart failure, kidney dysfunction and left ventricular ejection fraction, hazard ratio were not different with Crude hazardratio. Conclusions: Hyperuricemia was associated higher incidence of Major Adverse Cardiac Events with hazard ratio 1.676 in survival analysis in seven days in hypertension patients with Acute Coronary Syndrome.;Background: Hypertension has strong correlation with uric acid levels. Many studies shows that hyperuricemia make worse major adverse cardiac events (MACE) in acute coronary syndrome patients. This study wants to assess the clinical value of hyperuricemia to make major adverse cardiac events in seven days in hypertension patients with acute coronary syndrome Methods: This is a retrospective cohort study by using medical record in intensive care coronary unit RSCM hospital. We evaluated two hundred fifty consecutive inpatients who were hospitalized by acute coronary syndrome with hypertensionfrom 2009 to 2014. Data were analized with Kaplan Meir curved, Cox proportional hazard regression, Cox proportional hazard regression multivariate analysis.Results: Incidence of MACE in hyperuremic patients were 38 from 125 patients (30.4%) and no hyperuricemic patients were 16 from 125 patients (12.8%). Hyperuricemia was associated higher incidence of MACE with hazard ratio 1.676 (CI 1.254-2.260). After adjustment comorbid factors which are inhomogeneity inbaseline characteristics for acute heart failure, kidney dysfunction and left ventricular ejection fraction, hazard ratio were not different with Crude hazardratio. Conclusions: Hyperuricemia was associated higher incidence of Major Adverse Cardiac Events with hazard ratio 1.676 in survival analysis in seven days inhypertension patients with Acute Coronary Syndrome;Background: Hypertension has strong correlation with uric acid levels. Many studies shows that hyperuricemia make worse major adverse cardiac events (MACE) in acute coronary syndrome patients. This study wants to assess the clinical value of hyperuricemia to make major adverse cardiac events in seven days in hypertension patients with acute coronary syndrome Methods: This is a retrospective cohort study by using medical record in intensive care coronary unit RSCM hospital. We evaluated two hundred fifty consecutive inpatients who were hospitalized by acute coronary syndrome with hypertensionfrom 2009 to 2014. Data were analized with Kaplan Meir curved, Cox proportional hazard regression, Cox proportional hazard regression multivariate analysis.Results: Incidence of MACE in hyperuremic patients were 38 from 125 patients (30.4%) and no hyperuricemic patients were 16 from 125 patients (12.8%). Hyperuricemia was associated higher incidence of MACE with hazard ratio 1.676 (CI 1.254-2.260). After adjustment comorbid factors which are inhomogeneity inbaseline characteristics for acute heart failure, kidney dysfunction and left ventricular ejection fraction, hazard ratio were not different with Crude hazardratio. Conclusions: Hyperuricemia was associated higher incidence of Major Adverse Cardiac Events with hazard ratio 1.676 in survival analysis in seven days inhypertension patients with Acute Coronary Syndrome;Background: Hypertension has strong correlation with uric acid levels. Many studies shows that hyperuricemia make worse major adverse cardiac events (MACE) in acute coronary syndrome patients. This study wants to assess the clinical value of hyperuricemia to make major adverse cardiac events in seven days in hypertension patients with acute coronary syndrome Methods: This is a retrospective cohort study by using medical record in intensive care coronary unit RSCM hospital. We evaluated two hundred fifty consecutive inpatients who were hospitalized by acute coronary syndrome with hypertensionfrom 2009 to 2014. Data were analized with Kaplan Meir curved, Cox proportional hazard regression, Cox proportional hazard regression multivariate analysis.Results: Incidence of MACE in hyperuremic patients were 38 from 125 patients (30.4%) and no hyperuricemic patients were 16 from 125 patients (12.8%). Hyperuricemia was associated higher incidence of MACE with hazard ratio 1.676 (CI 1.254-2.260). After adjustment comorbid factors which are inhomogeneity inbaseline characteristics for acute heart failure, kidney dysfunction and left ventricular ejection fraction, hazard ratio were not different with Crude hazardratio. Conclusions: Hyperuricemia was associated higher incidence of Major Adverse Cardiac Events with hazard ratio 1.676 in survival analysis in seven days inhypertension patients with Acute Coronary Syndrome;Background: Hypertension has strong correlation with uric acid levels. Many studies shows that hyperuricemia make worse major adverse cardiac events (MACE) in acute coronary syndrome patients. This study wants to assess the clinical value of hyperuricemia to make major adverse cardiac events in seven days in hypertension patients with acute coronary syndrome Methods: This is a retrospective cohort study by using medical record in intensive care coronary unit RSCM hospital. We evaluated two hundred fifty consecutive inpatients who were hospitalized by acute coronary syndrome with hypertensionfrom 2009 to 2014. Data were analized with Kaplan Meir curved, Cox proportional hazard regression, Cox proportional hazard regression multivariate analysis.Results: Incidence of MACE in hyperuremic patients were 38 from 125 patients (30.4%) and no hyperuricemic patients were 16 from 125 patients (12.8%). Hyperuricemia was associated higher incidence of MACE with hazard ratio 1.676 (CI 1.254-2.260). After adjustment comorbid factors which are inhomogeneity inbaseline characteristics for acute heart failure, kidney dysfunction and left ventricular ejection fraction, hazard ratio were not different with Crude hazardratio. Conclusions: Hyperuricemia was associated higher incidence of Major Adverse Cardiac Events with hazard ratio 1.676 in survival analysis in seven days inhypertension patients with Acute Coronary Syndrome, Background: Hypertension has strong correlation with uric acid levels. Many studies shows that hyperuricemia make worse major adverse cardiac events (MACE) in acute coronary syndrome patients. This study wants to assess the clinical value of hyperuricemia to make major adverse cardiac events in seven days in hypertension patients with acute coronary syndrome Methods: This is a retrospective cohort study by using medical record in intensive care coronary unit RSCM hospital. We evaluated two hundred fifty consecutive inpatients who were hospitalized by acute coronary syndrome with hypertensionfrom 2009 to 2014. Data were analized with Kaplan Meir curved, Cox proportional hazard regression, Cox proportional hazard regression multivariate analysis.Results: Incidence of MACE in hyperuremic patients were 38 from 125 patients (30.4%) and no hyperuricemic patients were 16 from 125 patients (12.8%). Hyperuricemia was associated higher incidence of MACE with hazard ratio 1.676 (CI 1.254-2.260). After adjustment comorbid factors which are inhomogeneity inbaseline characteristics for acute heart failure, kidney dysfunction and left ventricular ejection fraction, hazard ratio were not different with Crude hazardratio. Conclusions: Hyperuricemia was associated higher incidence of Major Adverse Cardiac Events with hazard ratio 1.676 in survival analysis in seven days inhypertension patients with Acute Coronary Syndrome] |
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