[ABSTRAK Terapi Paliatif bertujuan untuk meningkatkan kualitas hidup dan mengurangigejala, namun menambah kompleksitas terapi pasien. Penelitian ini bertujuanuntuk menganalisis profil pengobatan dan prevalensi DRPs yang terjadi padapasien yang menjalani terapi paliatif di RSK ?Dharmais?. Penelitian ini adalahpenelitian cross sectional. Data pada penelitian diambil secara prospektif dari datamedis pasien bulan maret sampai juni 2011. Karakteristik pasien, 33 orang(68,8%) perempuan, 15 orang (31,3%) laki-laki, dan kasus kanker padat terbesaradalah kasus kanker payudara sebanyak 15 orang (33,3%). Berdasarkan profilpengobatan, 64,6% hanya menjalani satu kali terapi paliatif. Reaksi obat yangtidak diinginkan (ROTD) manifestasi dialami olah 70,1% subyek uji dan 66,2%mengalami ROTD potensial. Lima koma tujuh persen (5,7%) mengalami interaksidengan signifikansi moderate dan 15,0% terjadi karena pemakaian morphine, danamitriptyline. Peningkatan risiko kejadian ROTD dipengaruhi oleh (1) usia,bertambahnya usia tidak selalu menyebabkan peningkatan ROTD manifestasi; (2)jenis kelamin, laki-laki akan lebih berisiko mengalami peningkatan ROTDmanifestasi; (3) riwayat rejimen kemoterapi kuratif, meningkatkan risiko ROTDmanifestasi; (4) penyakit penyerta, meningkatkan risiko ROTD manifestasi danpotensial; (5) jumlah obat; penggunaan > 5 jenis obat dapat meningkatkan risikoROTD manifestasi dan ROTD potensial. Risiko kejadian interaksi obatdipengaruhi oleh faktor adanya penyakit penyerta dan penggunaan > 5 jenis obat. ABSTRACT The goal of palliative care is to increase the quality of life and to reduce thesymptomps, but its often increace the complexity of patient?s therapy. The aim ofthese research is to analyst the patient?s therapy profile and the prevalence ofDRPs of patient undergoing the palliative care at ?Dharmais? Hospital NationalCancer Center. This reasearch is a cross sectional study. The data of the researchis prospectively taken from the patients? medical records start from march to june2011. The patient characteristic who followed the reasearch are 33 patients(68.8%) women, 15 patient (31.3%) men, and the most solid cancer case arebreast cancer, 15 patients (31.3%). Based on therapy profile, 64.6% only hadonce palliative care. Manifest adverse reaction happen in 70.1% patient ofsubject and 66.2% subjects get potential adverse reaction. Five point sevenpercent (5.7%) of drug interaction had moderate signification, 15.0% caused bythe morphine, and amitriptyline use. The risk of incident adverse reactionsinfluenced by (1) age, increasing the age not always increase the risk of havingthe manifest adverse reaction, (2) sex, men will have higher risk of manifestadverse reaction, (3) history of curative chemotherapy regimen, increase the riskof manifest adverse reaction, (4) comorbidities will increase the risk of manifestand potential adverse reaction, (5) the number of drug use, using more than 5drugs ( > 5 drugs) will increase the risk of manifest and potential adversereaction. The risk of drug interaction will increase because of the comorbiditiesand the number of drugs using ( > 5 drugs).;The goal of palliative care is to increase the quality of life and to reduce thesymptomps, but its often increace the complexity of patient’s therapy. The aim ofthese research is to analyst the patient’s therapy profile and the prevalence ofDRPs of patient undergoing the palliative care at “Dharmais” Hospital NationalCancer Center. This reasearch is a cross sectional study. The data of the researchis prospectively taken from the patients’ medical records start from march to june2011. The patient characteristic who followed the reasearch are 33 patients(68.8%) women, 15 patient (31.3%) men, and the most solid cancer case arebreast cancer, 15 patients (31.3%). Based on therapy profile, 64.6% only hadonce palliative care. Manifest adverse reaction happen in 70.1% patient ofsubject and 66.2% subjects get potential adverse reaction. Five point sevenpercent (5.7%) of drug interaction had moderate signification, 15.0% caused bythe morphine, and amitriptyline use. The risk of incident adverse reactionsinfluenced by (1) age, increasing the age not always increase the risk of havingthe manifest adverse reaction, (2) sex, men will have higher risk of manifestadverse reaction, (3) history of curative chemotherapy regimen, increase the riskof manifest adverse reaction, (4) comorbidities will increase the risk of manifestand potential adverse reaction, (5) the number of drug use, using more than 5drugs ( > 5 drugs) will increase the risk of manifest and potential adversereaction. The risk of drug interaction will increase because of the comorbiditiesand the number of drugs using ( > 5 drugs)., The goal of palliative care is to increase the quality of life and to reduce thesymptomps, but its often increace the complexity of patient’s therapy. The aim ofthese research is to analyst the patient’s therapy profile and the prevalence ofDRPs of patient undergoing the palliative care at “Dharmais” Hospital NationalCancer Center. This reasearch is a cross sectional study. The data of the researchis prospectively taken from the patients’ medical records start from march to june2011. The patient characteristic who followed the reasearch are 33 patients(68.8%) women, 15 patient (31.3%) men, and the most solid cancer case arebreast cancer, 15 patients (31.3%). Based on therapy profile, 64.6% only hadonce palliative care. Manifest adverse reaction happen in 70.1% patient ofsubject and 66.2% subjects get potential adverse reaction. Five point sevenpercent (5.7%) of drug interaction had moderate signification, 15.0% caused bythe morphine, and amitriptyline use. The risk of incident adverse reactionsinfluenced by (1) age, increasing the age not always increase the risk of havingthe manifest adverse reaction, (2) sex, men will have higher risk of manifestadverse reaction, (3) history of curative chemotherapy regimen, increase the riskof manifest adverse reaction, (4) comorbidities will increase the risk of manifestand potential adverse reaction, (5) the number of drug use, using more than 5drugs ( > 5 drugs) will increase the risk of manifest and potential adversereaction. The risk of drug interaction will increase because of the comorbiditiesand the number of drugs using ( > 5 drugs).] |