[Latar Belakang: Salah satu masalah dalam tatalaksana karsinoma nasofaring(KNF) adalah masih tingginya angka rekurensi pascaterapi. Hingga saat ini,biomarker yang digunakan di klinik untuk mengevaluasi hasil terapi definitif padaKNF adalah melalui CT scan nasofaring. Overekspresi Rad51 berhubungandengan peningkatan resistensi sel tumor terhadap radiasi dan kemoterapi. Olehkarena rekurensi pascaterapi berhubungan dengan resistensi sel-sel tumornya,maka penelitian ini dilakukan dengan tujuan untuk menilai korelasi antaraekspresi Rad51 pada biopsi nasofaring sebelum terapi dengan penyusutan massatumor pascaterapi yang diukur dengan metode unidimensional.Bahan dan Metode: Studi potong lintang dilakukan pada 15 kasus KNF.Ekspresi Rad51 dinilai dari biopsi nasofaring sebelum terapi. Evaluasi hasil terapidilihat dari penyusutan massa tumor, berdasarkan CT scan nasofaring sebelumdan setelah terapi definitif. Cara yang digunakan untuk mengukur penyusutanmassa tumor adalah dengan mengukur diameter terpanjang (unidimensional).Hasil: Ekspresi dari pewarnaan Rad51 yang dinilai berdasarkan skor-Hmenunjukkan hubungan bermakna dan korelasi yang kuat dengan penyusutanmassa tumor. Diperoleh nilai p = 0,005 dan koefisien korelasi r = - 0,64.Kesimpulan: Ekspresi Rad51 memiliki korelasi negatif dengan penyusutan massatumor karsinoma nasofaring.
Background: The remain challenging problem in the managementof nasopharyngeal carcinoma (NPC) is its higher rate of recurrency. Untill now,CT scan is the most common use biomarker to evaluate the treatment responseafter the definitive therapy. There’s a significance association between Rad51overexpression and the increasing of resistancy to irradiation and chemotherapyin tumor cells and the resistancy of tumor cells correlates to its recurrency aftertherapy. Therefore, this study was conducted to evaluate the correlation betweenRad51 expression level and the tumor’s shrinkage with unidimensionalmeasurement. Material and Methods: Fifteen cases of NPC were analyzed by a cross-sectionalstudy. The expression of Rad51 were taken from the pretreatment ofnasopharyngeal biopsy. The treatment response was evaluated from thenasopharyngeal CT scan, before and after definitive therapy, using theunidimensional measurement based on the change in sum longest diameter.Result: The expression of Rad51 immunostaining assessed by the H-score werestrongly correlate with the regression of the tumor mass which represent thetreatment response. The p value is 0,005 and the correlation’s coefficient is -0,64.Conclusion: There is significant correlation with negative magnitude between theexpression of Rad51 with the shrinkage of tumor mass in nasopharyngealcarcinoma.;Background: The remain challenging problem in the managementof nasopharyngeal carcinoma (NPC) is its higher rate of recurrency. Untill now,CT scan is the most common use biomarker to evaluate the treatment responseafter the definitive therapy. There’s a significance association between Rad51overexpression and the increasing of resistancy to irradiation and chemotherapyin tumor cells and the resistancy of tumor cells correlates to its recurrency aftertherapy. Therefore, this study was conducted to evaluate the correlation betweenRad51 expression level and the tumor’s shrinkage with unidimensionalmeasurement.Material and Methods: Fifteen cases of NPC were analyzed by a cross-sectionalstudy. The expression of Rad51 were taken from the pretreatment ofnasopharyngeal biopsy. The treatment response was evaluated from thenasopharyngeal CT scan, before and after definitive therapy, using theunidimensional measurement based on the change in sum longest diameter.Result: The expression of Rad51 immunostaining assessed by the H-score werestrongly correlate with the regression of the tumor mass which represent thetreatment response. The p value is 0,005 and the correlation’s coefficient is -0,64.Conclusion: There is significant correlation with negative magnitude between theexpression of Rad51 with the shrinkage of tumor mass in nasopharyngealcarcinoma., Background: The remain challenging problem in the managementof nasopharyngeal carcinoma (NPC) is its higher rate of recurrency. Untill now,CT scan is the most common use biomarker to evaluate the treatment responseafter the definitive therapy. There’s a significance association between Rad51overexpression and the increasing of resistancy to irradiation and chemotherapyin tumor cells and the resistancy of tumor cells correlates to its recurrency aftertherapy. Therefore, this study was conducted to evaluate the correlation betweenRad51 expression level and the tumor’s shrinkage with unidimensionalmeasurement.Material and Methods: Fifteen cases of NPC were analyzed by a cross-sectionalstudy. The expression of Rad51 were taken from the pretreatment ofnasopharyngeal biopsy. The treatment response was evaluated from thenasopharyngeal CT scan, before and after definitive therapy, using theunidimensional measurement based on the change in sum longest diameter.Result: The expression of Rad51 immunostaining assessed by the H-score werestrongly correlate with the regression of the tumor mass which represent thetreatment response. The p value is 0,005 and the correlation’s coefficient is -0,64.Conclusion: There is significant correlation with negative magnitude between theexpression of Rad51 with the shrinkage of tumor mass in nasopharyngealcarcinoma.] |
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