[ Latar Belakang Tindakan peritomi konjungtiva meningkatkan penanda inflamasipada permukaan okular dan menyebabkan penurunan densitas sel goblet yangberimplikasi pada ketidakstabilan lapisan air mata. Pemberian HP-guar diharapkanmampu memperbaiki keadaan permukaan okular pasca peritomi konjungtiva 360°dibandingkan kontrol.Tujuan Untuk menilai efektivitas artificial tears HP-guar dalam melindungipermukaan okular pasien pasca peritomi konjungtiva 360°.Desain Penelitian prospektif, uji klinis open labelHasil Terdapat 23 subjek yang berpartisipasi dalam penelitian ini. Kelompok HP-guarmenunjukkan hasil yang lebih baik dibandingkan dengan kelompok kontrol secarasignifikan dalam hal TFBUT (9,43+2,20 vs 5,95+1,93, p=0,001), densitas sel goblet(68,73 ±97,49 vs 10,00 ± 22,09,p =0,012), skor epitel (1,73±1.00 vs 4,55±1.57,p=0.000). Tidak terdapat perbedaan bermakna antara kedua kelompok dalam hal skorlissamine green (1,33±1,55 vs 2,18±1,72, p=0,146) dan IL-6 air mata (60,32 ±17,86vs 57,44 ±24,67, p=0,782)Kesimpulan Pemberian HP-guar lebih memperbaiki nilai TFBUT, densitas sel gobletdan epitel konjungtiva dibandingkan kontrol. HP-guar tidak berpengaruh terhadapskor lissamine green dan kadar IL-6 air mata., Background Conjunctival peritomy, a step commonly done in ocular surgery,increases ocular surface inflammation and decreases goblet cell density (GCD) thatcould lead to tear film instability. Hydroxypropyl-guar (HP-guar) is expected toimprove ocular surface related to conjunctival peritomyPurpose To evaluate HP-guar effectiveness in protecting ocular surface afterconjunctival peritomyMethods Randomized controlled trial, open label study, on subjects underwent scleralbuckling surgeryResult Twenty-three participants were involved in this study. The HP-guar groupshowed statistically better results compared to the control group regarding Tear-filmbreak-up time (TFBUT) (9,43±2,20 vs 5,95±1,93, p=0.001), GCD (68,73 ±97,49 vs10,00 ± 22,09,p =0.012), and epithelial score (1.73±1.00 vs 4.55±1.57, p=0.000). Nostatistical differences were found between groups in lissamine green score (1.33±1.55vs 2.18±1.72, p=0.146) and IL-6 tear fluid level (60.32 ±17.86 vs 57.44 ±24.67,p=0.782)Conclusion The addition of HP-Guar to regular treatment after conjunctival peritomyincreases TFBUT, goblet cell density, and improves conjunctival epithelial cells. HPguarhas no effect on ocular surface inflammation.] |