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[Latar belakang: Transplantasi ginjal dapat memperbaiki fungsi endotel. Berbagaipenelitian membuktikan bahwa peningkatan kadar eritropoietin (Epo) dapatmengaktifasi dan memobilisasi Endothelial Progenitor Cell (EPC) sehingga mampumemperbaiki fungsi endotel melalui proses angiogenesis dan neovaskularisasi.Membaiknya fungsi endotel akan menurunkan angka kesakitan dan kematian akibatpenyakit kardiovaskular pada penderita PGK.Tujuan: Untuk mengetahui hubungan peningkatan kadar Epo dan jumlah EPCCD34+ serta CD133+ dengan perbaikan fungsi endotel pada penderita gagal ginjal 3bulan setelah transplantasi ginjal.Metode Penelitian: Potong lintang sebelum dengan 3 bulan setelah transplantasiginjal pada penderita gagal ginjal yang menjalani transplantasi ginjal di RSCM.Jumlah subyek 21 orang yang dikumpulkan dalam kurun waktu Juli 2013 – Februari2014. Pengambilan sampel darah untuk memeriksa kadar Epo, jumlah EPC CD34+dan CD133+ dan kadar asimetrik dimetilarginin (ADMA) dilakukan sebelum dan 3bulan setelah transplantasi ginjal. Analisis statistik dengan uji korelasi Pearson atauSpearman.Hasil: Penelitian ini menunjukkan adanya peningkatan kadar Epo tetapi tidakbermakna secara statistik (p>0.05), sedangkan jumlah EPC CD34+ dan CD133+meningkat (p<0.05), serta kadar ADMA menurun yang bermakna secara statistik(p<0.05). Tiga bulan setelah transplantasi ada korelasi bermakna antara peningkatankadar Epo dengan jumlah EPC CD34+ (r = 0.466 ; p < 0.05). Tidak ada hubunganpeningkatan kadar Epo dan jumlah EPC CD34+ serta CD133+ dengan perbaikanfungsi endotel 3 bulan setelah transplantasi ginjal.Kesimpulan: Tiga bulan setelah transplantasi ginjal didapatkan adanya peningkatankadar Epo, jumlah EPC CD34+ dan CD133+ serta penurunan kadar ADMA. Tetapitidak ada korelasi peningkatan kadar Epo dan jumlah EPC CD34+ serta CD133+dengan perbaikan fungsi endotel dalam rentang 3 bulan setelah transplantasi ginjal., Background: Kidney transplantation improved endothelial function. Various studieshave shown that elevated level of erythropoietin (Epo) could activate and mobilizeEndothelial Progenitor Cell (EPC), thus would improve endothelial function throughthe process of angiogenesis and neovascularization. The improvement of endothelialfunction will decrease morbidity and mortality from cardiovascular disease in patientswith CKD.Aim: To determine association between elevated level of Epo and the numbers ofEPC CD34+ - CD133+ with the improvement of endothelial function in patients threemonths after kidney transplantation.Methods: cross sectional study prior and 3 months after kidney transplantation inpatients with renal failure who underwent kidney transplantation in RSCM. The studyincluded 21 subjects who enrolled from July 2013 to February 2014. Blood samplesprior and 3 months after kidney transplantation were collected to evaluate the level ofEpo, numbers of EPC CD34+ and CD133+ and level of assymetric dimethylarginine(ADMA). Statistical analysis was performed using Pearson or Spearman correlationtest.Resulys: The results of the study showed that prior to kidney transplantation, level ofEpo was increased but not statistically significant (p>0.05). The EPC numbers ofCD34+ and CD133+ were significantly increased (p<0.05), whereas the ADMA levelwas significantly decreased (p<0.05). Three months after transplantation showed asignificant association between elevated level of Epo and the numbers of EPC CD34+(r = 0.466, p > 0.05). There was no association between the elevated level of Epo andthe numbers of EPC CD34+ and CD133+ with the improvement of endothelialfunction three months after kidney transplantation.Conclusion: Three months after kidney transplantation showed an elevated level ofEpo, the numbers of EPC CD34+ and CD133+ and the decreased level of ADMA.However, there was no association between the elevated level of Epo and thenumbers of EPC CD34+ and CD133+ with the improvement of endothelial function inpatients 3 months after kidney transplantation] |
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