[Pendahuluan: Kanker payudara lokal lanjut merupakan skenario klinis yang amatsering dijumpai di negara berkembang, dimana rekurensi masih menjadipermasalahan. Mastektomi merupakan salah satu terapi utama. Usia, stadiumklinis, keterlibatan kelenjar getah bening, tipe histopatologis, grade histopatologis,subtipe tumor merupakan faktor-faktor klinikohistopatologis yang mempengaruhirekurensi. Tujuan penelitian ini adalah untuk mengetahui pengaruh faktor-faktortersebut terhadap rekurensi kanker payudara lokal lanjut pasca mastektomi.Metode: Desain penelitian bersifat analitik potong lintang. Pengumpulan datadilakukan pada semua pasien kanker payudara lokal lanjut yang telah dilakukanmastektomi serta terapi definitif sesuai stadium tumor dan terdapat disease freeinterval serta dapat diikuti minimal 24 bulan pada periode Januari 2011 –Desember 2012 di RS Dr.Cipto Mangunkusumo.Hasil: Didapatkan 39 pasien dengan kanker payudara lokal lanjut yang telahdilakukan mastektomi serta terapi definitif dan terdapat disease free intervaldengan median follow up 30 bulan. Jumlah rekurensi adalah 7,6%. Pada analisisbivariat ditemukan hubungan bermakna antara jenis histopatologi (p 0,008) danketerlibatan kelenjar getah bening (p 0,026) dengan rekurensi. Pada analisismultivariat didapati faktor yang paling berpengaruh terhadap rekurensi adalahketerlibatan kelenjar getah bening (p 0,002).Konklusi: Faktor yang paling berpengaruh terhadap terjadinya rekurensi kankerpayudara lokal lanjut pasca mastektomi adalah kelenjar getah bening positif tumordengan jumlah lebih dari tiga.;Introduction: Locally advanced breast cancer is clinical scenario that is verycommon in developing countries where recurrence is still a problem. Mastectomyis one of the primary teraphy. Age, clinical stage, lymph nodes involvement,histopathlogic type, histopatologic grades, tumor subtypes areclinicohystopatoligic factors affecting recurrence. The purpose of this study wasto determine the influence of these factors on the recurrence of locally advancedbreast cancer after mastectomy.Methodology: The study design was analytical cross-sectional. Data collectionwas performed in all patients with locally advanced breast cancer who hadperformed mastectomy and appropriate definitive therapy according to tumorstage, had disease free interval and can be followed at least 24 month in the periodJanuary 2011 – December 2012 at the Hospital Dr. Cipto Mangunkusumo.Result: There were 39 patient with locally advanced breast cancer patient who hadperformed mastectomy as well as definitive therapy, had disease free interval witha median follow-up interval of 30 months. The number of recurrences was 7,6%.In the bivariate analysis found a significant relationship between thehystopathology type (p 0,008), lymph node involvement (p 0,026) withrecurrence. In multivariate analysis found that the most influential factor toreccurrence was lymph node involvement (p 0,002).Conclusion: The most influential factor on the occurrence of locally advancedbreast cancer recurrence after mastectomy is tumor positive lymph nodes in anamount greater than three.;Introduction: Locally advanced breast cancer is clinical scenario that is verycommon in developing countries where recurrence is still a problem. Mastectomyis one of the primary teraphy. Age, clinical stage, lymph nodes involvement,histopathlogic type, histopatologic grades, tumor subtypes areclinicohystopatoligic factors affecting recurrence. The purpose of this study wasto determine the influence of these factors on the recurrence of locally advancedbreast cancer after mastectomy.Methodology: The study design was analytical cross-sectional. Data collectionwas performed in all patients with locally advanced breast cancer who hadperformed mastectomy and appropriate definitive therapy according to tumorstage, had disease free interval and can be followed at least 24 month in the periodJanuary 2011 – December 2012 at the Hospital Dr. Cipto Mangunkusumo.Result: There were 39 patient with locally advanced breast cancer patient who hadperformed mastectomy as well as definitive therapy, had disease free interval witha median follow-up interval of 30 months. The number of recurrences was 7,6%.In the bivariate analysis found a significant relationship between thehystopathology type (p 0,008), lymph node involvement (p 0,026) withrecurrence. In multivariate analysis found that the most influential factor toreccurrence was lymph node involvement (p 0,002).Conclusion: The most influential factor on the occurrence of locally advancedbreast cancer recurrence after mastectomy is tumor positive lymph nodes in anamount greater than three., Introduction: Locally advanced breast cancer is clinical scenario that is verycommon in developing countries where recurrence is still a problem. Mastectomyis one of the primary teraphy. Age, clinical stage, lymph nodes involvement,histopathlogic type, histopatologic grades, tumor subtypes areclinicohystopatoligic factors affecting recurrence. The purpose of this study wasto determine the influence of these factors on the recurrence of locally advancedbreast cancer after mastectomy.Methodology: The study design was analytical cross-sectional. Data collectionwas performed in all patients with locally advanced breast cancer who hadperformed mastectomy and appropriate definitive therapy according to tumorstage, had disease free interval and can be followed at least 24 month in the periodJanuary 2011 – December 2012 at the Hospital Dr. Cipto Mangunkusumo.Result: There were 39 patient with locally advanced breast cancer patient who hadperformed mastectomy as well as definitive therapy, had disease free interval witha median follow-up interval of 30 months. The number of recurrences was 7,6%.In the bivariate analysis found a significant relationship between thehystopathology type (p 0,008), lymph node involvement (p 0,026) withrecurrence. In multivariate analysis found that the most influential factor toreccurrence was lymph node involvement (p 0,002).Conclusion: The most influential factor on the occurrence of locally advancedbreast cancer recurrence after mastectomy is tumor positive lymph nodes in anamount greater than three.] |