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Protein-ligand interactions from molecular recognition to drug design

edited by H.-J. Bohm and G. Schneider (Wiley-VCH, 2003)

 Abstrak

The lock-and-key principle formulated by Emil Fischer as early as the end of the 19th century has still not lost any of its significance for the life sciences. The basic aspects of ligand-protein interaction may be summarized under the term 'molecular recognition' and concern the specificity as well as stability of ligand binding. Molecular recognition is thus a central topic in the development of active substances, since stability and specificity determine whether a substance can be used as a drug. Nowadays, computer-aided prediction and intelligent molecular design make a large contribution to the constant search for, e. g., improved enzyme inhibitors, and new concepts such as that of pharmacophores are being developed.

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 Metadata

No. Panggil : e20394591
Entri tambahan-Nama orang :
Subjek :
Penerbitan : Weinheim, Germany: Wiley-VCH, 2003
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Tipe Konten:
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Deskripsi Fisik:
Tautan: http://onlinelibrary.wiley.com/book/10.1002/3527601813
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No. Panggil No. Barkod Ketersediaan
e20394591 20-22-02030242 TERSEDIA
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