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Caveolins and caveolae: roles in signaling and disease mechanisms

edited by Jean-François Jasmin, Philippe G. Frank, Michael P. Lisanti (Springer, 2012)

 Abstrak

Caveolae are 50-100 nm flask-shaped invaginations of the plasma membrane that are primarily composed of cholesterol and sphingolipids. Using modern electron microscopy techniques, caveolae can be observed as omega-shaped invaginations of the plasma membrane, fully-invaginated caveolae, grape-like clusters of interconnected caveolae (caveosome), or as transcellular channels as a consequence of the fusion of individual caveolae. The caveolin gene family consists of three distinct members, namely Cav-1, Cav-2 and Cav-3. Cav-1 and Cav-2 proteins are usually co-expressed and particularly abundant in epithelial, endothelial, and smooth muscle cells as well as adipocytes and fibroblasts. On the other hand, the Cav-3 protein appears to be muscle-specific and is therefore only expressed in smooth, skeletal and cardiac muscles. Caveolin proteins form high molecular weight homo- and/or hetero-oligomers and assume an unusual topology with both their N- and C-terminal domains facing the cytoplasm.

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 Metadata

No. Panggil : e20401435
Entri tambahan-Nama orang :
Subjek :
Penerbitan : New York: Springer, 2012
Sumber Pengatalogan: LibUI eng rda
Tipe Konten: text
Tipe Media: computer
Tipe Pembawa: online resource
Deskripsi Fisik:
Tautan: http://link.springer.com/book/10.1007%2F978-1-4614-1222-9
Lembaga Pemilik:
Lokasi:
  • Ketersediaan
  • Ulasan
No. Panggil No. Barkod Ketersediaan
e20401435 20-22-34405233 TERSEDIA
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