Status metilasi gen Interleukin 8 (IL-8) pada penderita Periodontitis = Methylation status of interleukin 8 il 8 gene in periodontitis patients / Ananda Ghina Lugiena
Ananda Ghina Lugiena;
A. Winoto Suhartono, supervisor; Elza Ibrahim, supervisor
(Fakultas Kedokteran Gigi Universitas Indonesia, 2014)
|
ABSTRAK Latar Belakang: Metilasi menyebabkan perubahan ekspresi gen IL-8 yang berperan dalam kemotaksis neutrofil pada periodontitis. Tujuan: mengetahui distribusi status metilasi gen IL-8 pada periodontitis, dan perbedaan distribusi status metilasi IL-8 pada periodontitis dengan normal. Metode: modifikasi bisulfit dengan MS-PCR digunakan untuk menganalisis 65 subjek kontrol dan 35 subjek periodontitis. Hasil: 3 sampel (3%) berstatus fully methylated, 97 sampel (97%)berstatus partially methylated, dan tidak terdapat status fully unmethylated.Kesimpulan: Tidak terdapat perbedaan yang signifikan antara status metilasi gen IL-8 pada penderita periodontitis dan individu normal (p=>0.05). ABSTRACT Background: methylation results in modification of IL-8 gene expression which acts as chemotaxis factor of neutrophil in periodontitis. Objectives: describe the distribution of methylation status of IL-8 gene in periodontitis and to observe the difference of methylation status distribution of IL-8 in periodontitis and healthy individuals. Methods: bisulfite modification and MS-PCR were used to analyze65 controls and 35 periodontitis subjects. Result: for all subjects, 3 samples (3%) were fully methylated, 97 (97%) partially methylated, and none fully unmethylated. Conclusion: no significant difference was found in the methylationstatus of IL-8 between periodontitis patients and healthy individuals (p=>0.05). |
![]()
|
No. Panggil : | S-Pdf |
Entri utama-Nama orang : | |
Entri tambahan-Nama orang : | |
Subjek : | |
Penerbitan : | [Place of publication not identified]: Fakultas Kedokteran Gigi Universitas Indonesia, 2014 |
Program Studi : |
Bahasa : | ind |
Sumber Pengatalogan : | LibUI ita rda |
Tipe Konten : | text |
Tipe Media : | unmediated ; computer |
Tipe Carrier : | volume ; online resource |
Deskripsi Fisik : | xvi, 49 pages : illustration ; 28 cm |
Naskah Ringkas : | |
Lembaga Pemilik : | Universitas Indonesia |
Lokasi : | Perpustakaan UI, Lantai 3 |
No. Panggil | No. Barkod | Ketersediaan |
---|---|---|
S-Pdf | TERSEDIA |
Ulasan: |
Tidak ada ulasan pada koleksi ini: 20402154 |