[ABSTRAK
Tujuan : Mengevaluasi ada tidaknya perbedaan kualitas air mata pada penderita glaukoma yangmengalami mata kering antara yang diberi tetes mata sodium hialuronat 0,1% mengandung bahanpengawet benzalkonium klorida dan tetes mata sodium hialuronat 0,1% tanpa bahan pengawet.Metode : Penelitian ini merupakan penelitian prospektif terandomisasi. 30 pasien glaukoma yangmengalami mata kering dirandomisasi ke dalam kedua kelompok. Kelompokpertama,mendapatkan obat tetes mata artificial tear mengandung sodium hialuronat 0,1% denganpengawet benzalkonium klorida, sedangkan kelompok II, mendapatkan obat tetes mata artificialtear mengandung sodium hialuronat 0,1% tanpa pengawet selama 1 bulan. Pemeriksaan Schirmertest, TFBUT, OPI, dan sitologi impresi dilakukan pada kedua kelompok baik sebelum dan sesudah1 bulan penetesan obat tetes mata artificial tear.Results: Nilai median sitologi impresi sel goblet pasca penetesan artificial tear meningkat padakelompok I (118,15-485) dan kelompok II (67.0-200), namun secara statistik tidak ada perbedaanbermakna. Nilai rata ? rata TFBUT pasca penetesan pada kelompok I (14,45±7,85) dan kelompokII (13,91±7,46) meningkat dibandingkan sebelum penetesan, serta secara statitstik memilikiperbedaan yang bermakna. Nilai Schirmer test dan OPI pasca penetesan pada kedua kelompokmengalami peningkatan secara klinis dibandingkan sebelum penetesan, namun tidak terdapatperbedaan bermakna secara statistik.Conclusions : Pemberian artificial tear mengandung sodium hialuronat 0,1% baik denganpengawet maupun tanpa pengawet selama 1 bulan memberikan peningkatan Schirmer test,TFBUT,OPI dan sitologi impresi sel goblet.
ABSTRACT
Objectives: To evaluate the difference of quality of tears between glaucoma patients sufferingfrom dry eyes treated with 0.1% sodium hyaluronat eyedrops with preservativebenzalconiumchloride and those treated with 0.1% sodium hyaluronat eyedrops withoutpreservative.Methods: This is a randomized prospective study. Subjects were 30 glaucoma patients sufferingfrom dry eyes, whom later randomized into two groups. Group I was treated with artificial tearseye drops, which contained 0.1% sodium hyaluronat and benzalconium chloride preservative,whereas Group II was treated with artificial tears eye drops, which contained 0.1% sodiumhyaluronat without preservative for one-month duration. Before and after the treatment withartificial tears eyedrops, subjects of both groups were tested with Schirmer test, TFBUT, OPI, andimpression cytology.Results: The median of goblet cells in impression cytology after treatment with artificial tears eyedrops increased in group I (118, 15 ? 485) and group II (67, 0 ? 200), even though not statisticallysignificant. Mean TFBUT after treatment was also higher in Group I (14.45±7.85) and Group II(13.91±7.46), yet not statistically significant. Schirmer test and OPI results after treatment showeda clinical improvement in both groups, however no statistic result was found to be significant.Conclusions: Treatment with artifical tears eye drops containing 0.1% sodium hyaluronat with orwithout preservative for one month will improve Schirmer test, TFBUT, OPI, and goblet cellsimpressions cytology result on glaucoma patients suffering from dry eyes.;Objectives: To evaluate the difference of quality of tears between glaucoma patients sufferingfrom dry eyes treated with 0.1% sodium hyaluronat eyedrops with preservativebenzalconiumchloride and those treated with 0.1% sodium hyaluronat eyedrops withoutpreservative.Methods: This is a randomized prospective study. Subjects were 30 glaucoma patients sufferingfrom dry eyes, whom later randomized into two groups. Group I was treated with artificial tearseye drops, which contained 0.1% sodium hyaluronat and benzalconium chloride preservative,whereas Group II was treated with artificial tears eye drops, which contained 0.1% sodiumhyaluronat without preservative for one-month duration. Before and after the treatment withartificial tears eyedrops, subjects of both groups were tested with Schirmer test, TFBUT, OPI, andimpression cytology.Results: The median of goblet cells in impression cytology after treatment with artificial tears eyedrops increased in group I (118, 15 – 485) and group II (67, 0 – 200), even though not statisticallysignificant. Mean TFBUT after treatment was also higher in Group I (14.45±7.85) and Group II(13.91±7.46), yet not statistically significant. Schirmer test and OPI results after treatment showeda clinical improvement in both groups, however no statistic result was found to be significant.Conclusions: Treatment with artifical tears eye drops containing 0.1% sodium hyaluronat with orwithout preservative for one month will improve Schirmer test, TFBUT, OPI, and goblet cellsimpressions cytology result on glaucoma patients suffering from dry eyes., Objectives: To evaluate the difference of quality of tears between glaucoma patients sufferingfrom dry eyes treated with 0.1% sodium hyaluronat eyedrops with preservativebenzalconiumchloride and those treated with 0.1% sodium hyaluronat eyedrops withoutpreservative.Methods: This is a randomized prospective study. Subjects were 30 glaucoma patients sufferingfrom dry eyes, whom later randomized into two groups. Group I was treated with artificial tearseye drops, which contained 0.1% sodium hyaluronat and benzalconium chloride preservative,whereas Group II was treated with artificial tears eye drops, which contained 0.1% sodiumhyaluronat without preservative for one-month duration. Before and after the treatment withartificial tears eyedrops, subjects of both groups were tested with Schirmer test, TFBUT, OPI, andimpression cytology.Results: The median of goblet cells in impression cytology after treatment with artificial tears eyedrops increased in group I (118, 15 – 485) and group II (67, 0 – 200), even though not statisticallysignificant. Mean TFBUT after treatment was also higher in Group I (14.45±7.85) and Group II(13.91±7.46), yet not statistically significant. Schirmer test and OPI results after treatment showeda clinical improvement in both groups, however no statistic result was found to be significant.Conclusions: Treatment with artifical tears eye drops containing 0.1% sodium hyaluronat with orwithout preservative for one month will improve Schirmer test, TFBUT, OPI, and goblet cellsimpressions cytology result on glaucoma patients suffering from dry eyes.] |
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