[ABSTRAK
Latar Belakang: Diare akut adalah masalah umum di negara berkembang sepertiIndonesia; penyakit ini banyak ditemukan dalam praktek sehari-hari dengan angkamorbiditas dan mortalitas yang cukup tinggi. Pada beberapa Rumah Sakit diJakarta ditemukan bahwa pasien diare akut dewasa mengalami defisiensi kadarseng sebesar 69.3%.Pemberian seng sudah terbukti bermanfaat untuk pengobatan diare akut padaanak.Tujuan: Mengetahui dampak suplementasi seng sebagai terapi alternatif /adjuvant untuk pengobatan diare akut pada pasien dewasa, denganmembandingkan lama berlangsung dan berat-ringan gejala pada kelompok pasienyang diberikan dan yang tidak diberikan suplementasi seng.Metode: Double blind randomized controlled trial dilakukan pada penelitian iniuntuk mengetahui efek suplementasi seng terhadap durasi dan gejalagastrointestinal pada pasien diare akut rawat inap di RS Pusat Pertamina di Jakartaselama periode Januari-Desember 2013. Analisis data dilakukan denganmenggunakan uji chi-square (x2) untuk perbandingan durasi diare dan uji generallinear model (GLM) untuk menilai tren perubahan gejala penyerta diare.Hasil: Analisis data dari 84 pasien yang dikelola: 30 pasien pria [seng 19,plasebo 11] dan 54 pasien wanita [seng 23, plasebo 31] ~ (p 0.111)memperlihatkan pemberian suplementasi seng bermakna mengurangi durasi diareakut (p 0.027) dan bermakna mengurangi gejala mual (p 0.032). Selain itu adatren perbaikan pada sebagian gejala penyerta diare akut, seperti sakit perut,frekuensi b.a.b., konsistensi feses, gejala muntah, kembung, dan gangguanaktivitas sehari-hari.Simpulan: Pemberian suplementasi seng bermakna membuat durasi diare akutlebih singkat dan bermakna mengurangi gejala mual, serta perbaikan padasebagian gejala gastrointestinal.
ABSTRACT
Background: Acute diarrhea is a common problem in developing countries suchas Indonesia; which is found in everyday practice with quite high morbidity andmortality rate. It was revealed in adult acute diarrhea patients in several hospitalsin Jakarta the levels of zinc deficiency was 69.3%. Zinc has been proven to bebeneficial in the treatment of acute diarrhea in pediatric patients.Objective: To discover the effectiveness of zinc supplementation as an adjuvanttherapy in acute diarrhea for adult patients by comparing the duration and theseverity of signs and symptoms of acute diarrhea between the zinc and placebogroup.Methods: A double blind randomized controlled trial is done to find out aboutthe effect of zinc supplementation to the duration, signs and symptoms on acutediarrheal in hospitalized adults patients in Pertamina Central Hospital in Jakartafrom January-December 2013. The data is analyzed using chi-square test (x2) forcomparing the duration of diarrhea and general linear model (GLM) to assesstrend changes accompanying symptoms of diarrhea.Results: Analysis of the data from 84 patients: 30 males [19 zinc, 11 placebo]and 54 females [23 zinc, 31 placebo] ~ (p 0.111) obtained zinc supplementationsignificantly reduced the duration of acute diarrhea (p 0.027) and significantlyreduce the symptoms of nausea (p 0.032). In addition there is trend ofimprovement in some acute diarrhea associated symptoms, such as abdominalpain, frequency of diarrhea, stool consistency, vomiting, bloating, and disruptionof daily activities.Conclusion: Zinc supplementation significantly reduce the duration of diarrhea,significantly reduce the symptoms of nausea; besides, improving some symptomsaccompanying acute diarrhea.;Background: Acute diarrhea is a common problem in developing countries suchas Indonesia; which is found in everyday practice with quite high morbidity andmortality rate. It was revealed in adult acute diarrhea patients in several hospitalsin Jakarta the levels of zinc deficiency was 69.3%. Zinc has been proven to bebeneficial in the treatment of acute diarrhea in pediatric patients.Objective: To discover the effectiveness of zinc supplementation as an adjuvanttherapy in acute diarrhea for adult patients by comparing the duration and theseverity of signs and symptoms of acute diarrhea between the zinc and placebogroup.Methods: A double blind randomized controlled trial is done to find out aboutthe effect of zinc supplementation to the duration, signs and symptoms on acutediarrheal in hospitalized adults patients in Pertamina Central Hospital in Jakartafrom January-December 2013. The data is analyzed using chi-square test (x2) forcomparing the duration of diarrhea and general linear model (GLM) to assesstrend changes accompanying symptoms of diarrhea.Results: Analysis of the data from 84 patients: 30 males [19 zinc, 11 placebo]and 54 females [23 zinc, 31 placebo] ~ (p 0.111) obtained zinc supplementationsignificantly reduced the duration of acute diarrhea (p 0.027) and significantlyreduce the symptoms of nausea (p 0.032). In addition there is trend ofimprovement in some acute diarrhea associated symptoms, such as abdominalpain, frequency of diarrhea, stool consistency, vomiting, bloating, and disruptionof daily activities.Conclusion: Zinc supplementation significantly reduce the duration of diarrhea,significantly reduce the symptoms of nausea; besides, improving some symptomsaccompanying acute diarrhea., Background: Acute diarrhea is a common problem in developing countries suchas Indonesia; which is found in everyday practice with quite high morbidity andmortality rate. It was revealed in adult acute diarrhea patients in several hospitalsin Jakarta the levels of zinc deficiency was 69.3%. Zinc has been proven to bebeneficial in the treatment of acute diarrhea in pediatric patients.Objective: To discover the effectiveness of zinc supplementation as an adjuvanttherapy in acute diarrhea for adult patients by comparing the duration and theseverity of signs and symptoms of acute diarrhea between the zinc and placebogroup.Methods: A double blind randomized controlled trial is done to find out aboutthe effect of zinc supplementation to the duration, signs and symptoms on acutediarrheal in hospitalized adults patients in Pertamina Central Hospital in Jakartafrom January-December 2013. The data is analyzed using chi-square test (x2) forcomparing the duration of diarrhea and general linear model (GLM) to assesstrend changes accompanying symptoms of diarrhea.Results: Analysis of the data from 84 patients: 30 males [19 zinc, 11 placebo]and 54 females [23 zinc, 31 placebo] ~ (p 0.111) obtained zinc supplementationsignificantly reduced the duration of acute diarrhea (p 0.027) and significantlyreduce the symptoms of nausea (p 0.032). In addition there is trend ofimprovement in some acute diarrhea associated symptoms, such as abdominalpain, frequency of diarrhea, stool consistency, vomiting, bloating, and disruptionof daily activities.Conclusion: Zinc supplementation significantly reduce the duration of diarrhea,significantly reduce the symptoms of nausea; besides, improving some symptomsaccompanying acute diarrhea.] |
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