[ABSTRAK
Latar Belakang: Minosiklin merupakan antibiotik dengan sifat bakteriostatikyang potensial mengeliminasi bakteri patogen periodontal. Kesembuhanperawatan periodontitis kronis umumnya ditunjukkan secara klinis danmikrobiologis. Tujuan: Menganalisis parameter klinis (penurunan kedalamanpoket dan indeks perdarahan gingiva, peningkatan perlekatan klinis) dan jumlahT. forsythia sebelum dan sesudah aplikasi gel Minosiklin HCl 2%. Metode:Empat puluh dua subjek menerima aplikasi gel Minosiklin HCl 2% sebanyakempat kali, kemudian dievaluasi parameter klinis dan T. forsythia dengan Real-Time Polymerase Chain Reaction (RT-PCR). Hasil: Terdapat perbedaanbermakna dari parameter klinis dan T. forsythia antara pemeriksaan awal dankontrol bulan ke-6 (p<0,05). Terdapat perbedaan bermakna antara hubunganpenurunan indeks perdarahan gingiva dengan jumlah T. forsythia (p<0,05).Kesimpulan: Aplikasi gel Minosiklin HCl 2% secara klinis dan mikrobiologisefektif dalam perawatan periodontitis kronis.
ABSTRACT
Background: Minocycline is known as one of the antibiotics with greatbacteriostatic effect to eliminate periodontal pathogen. Healthier periodontalenvironment is usually shown with better clinical and microbiological response.Objective: To clinically and microbiologically (T. forsythia) analyze the effect ofMinocycline HCl 2% for treatment of chronic periodontitis within six months.Methods: Forty-two subjects applied with Minocyline HCl 2% for four times.Clinical and microbiological examinations were evaluated on baseline, month-2,month-3, and month-6. T. forsythia was examined with Real-Time PolymeraseChain Reaction (RT-PCR) techniques. Result: There were significant differencesbetween Probing Pocket Depth, Papilla Bleeding Index, Clinical AttachmentLevel, and amount of T. forsythia in baseline compare to six months period(p<0.05). There was an association between the amount of T. forsythia and PapillaBleeding Index (p<0.05). Conclusion: Minocycline HCl 2% was effectiveclinically and microbiologically in chronic periodontitis therapy.;Background: Minocycline is known as one of the antibiotics with greatbacteriostatic effect to eliminate periodontal pathogen. Healthier periodontalenvironment is usually shown with better clinical and microbiological response.Objective: To clinically and microbiologically (T. forsythia) analyze the effect ofMinocycline HCl 2% for treatment of chronic periodontitis within six months.Methods: Forty-two subjects applied with Minocyline HCl 2% for four times.Clinical and microbiological examinations were evaluated on baseline, month-2,month-3, and month-6. T. forsythia was examined with Real-Time PolymeraseChain Reaction (RT-PCR) techniques. Result: There were significant differencesbetween Probing Pocket Depth, Papilla Bleeding Index, Clinical AttachmentLevel, and amount of T. forsythia in baseline compare to six months period(p<0.05). There was an association between the amount of T. forsythia and PapillaBleeding Index (p<0.05). Conclusion: Minocycline HCl 2% was effectiveclinically and microbiologically in chronic periodontitis therapy., Background: Minocycline is known as one of the antibiotics with greatbacteriostatic effect to eliminate periodontal pathogen. Healthier periodontalenvironment is usually shown with better clinical and microbiological response.Objective: To clinically and microbiologically (T. forsythia) analyze the effect ofMinocycline HCl 2% for treatment of chronic periodontitis within six months.Methods: Forty-two subjects applied with Minocyline HCl 2% for four times.Clinical and microbiological examinations were evaluated on baseline, month-2,month-3, and month-6. T. forsythia was examined with Real-Time PolymeraseChain Reaction (RT-PCR) techniques. Result: There were significant differencesbetween Probing Pocket Depth, Papilla Bleeding Index, Clinical AttachmentLevel, and amount of T. forsythia in baseline compare to six months period(p<0.05). There was an association between the amount of T. forsythia and PapillaBleeding Index (p<0.05). Conclusion: Minocycline HCl 2% was effectiveclinically and microbiologically in chronic periodontitis therapy.] |
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