[ABSTRAK
Rambut kepala yang tumbuh subur dan lebat mendukung penampilan seseorang. Bila mengalami kerontokan dan tidak segera diatasi dapat menyebabkan kebotakan. Saat ini telah dikembangkan bahan penyubur rambut yang berasal dari alam. Daun murbei yang telah lama dikenal sebagai bahan pencerah kulit untuk produk kosmetika, secara tradisional juga digunakan sebagai bahan penyubur rambut. Tujuan dari penelitian ini adalah untuk menganalisis aktivitas pertumbuhan rambut sediaan hair tonic ekstrak etanol daun murbei dan memperoleh sediaan hair tonic yang stabil dan aman. Hair tonic yang dibuat terdiri dari tiga kadar ekstrak etanol daun murbei, yaitu 4, 8, dan 16% (b/v). Cara pengujian aktivitas pertumbuhan rambut dengan mengoles sediaan pada punggung kelinci jantan galur New Zealand yang telah dibagi menjadi enam bagian perlakuan, yaitu kontrol normal, kontrol negatif (basis hair tonic), kontrol positif (minoksidil) dan ketiga sediaan tersebut. Pengukuran panjang rambut dilakukan pada hari ke-7, 14, 21, 28, 35, dan 42. Untuk ketebalan rambut diukur dengan Scanning Electron Microscope (SEM) pada minggu I dan VI, sedangkan kelebatan dan bobot rambut diukur pada minggu VI. Hasil analisis statistik menunjukkan kadar 4% dan 16% memiliki aktivitas yang setara dengan kontrol positif, sedangkan kadar 8% aktivitasnya lemah pada parameter kelebatan rambut. Sediaan hair tonic ekstrak etanol daun murbei yang dibuat bersifat stabil dalam penyimpanan. Untuk pengujian keamanan menggunakan metode Patch test dan HET-CAM. Hasilnya sediaan hair tonic yang dibuat aman digunakan untuk kulit dan sedikit iritan pada mata.
ABSTRACT
A person with lush and healthy hair has a looking good appearance. When hair are lost and were not treated, it can lead to baldness. Mulberry previously known as a skin lightening agent for cosmetic products, traditionally also used for hair growth. The purpose of this research is to analyze the activity of hair growth from hair tonic which contain ethanol extract of mulberry leaves and to obtain a stable and safe hair tonic product. Hair tonic from mulberry leaves was made into three concentration, they are 4, 8, and 16%. Activity of hair growth was tested by applying the product on the dorsal site of New Zealand male rabbits divided into six sections of treatment, namely normal, negative (base hair tonic), positive control (Minoxidil) and three concentrations. Hair length measurements performed on days 7th, 14th, 21st, 28th, 35th, and 42nd. Hair thickness was measured by Scanning Electron Microscope (SEM) at week 1st and 6th, while the hair density and weight were measured at weeks 6th. Statistical analysis showed that the concentration of 4% and 16% have an activity equivalent to the positive control, whereas the levels of 8% has weaker activity on density parameter. This hair tonic containing mulberry leaves extract are stable at storage. Skin safety test using Patch test was safe and HET-CAM methode showed mild eye irritation.;A person with lush and healthy hair has a looking good appearance. When hair are lost and were not treated, it can lead to baldness. Mulberry previously known as a skin lightening agent for cosmetic products, traditionally also used for hair growth. The purpose of this research is to analyze the activity of hair growth from hair tonic which contain ethanol extract of mulberry leaves and to obtain a stable and safe hair tonic product. Hair tonic from mulberry leaves was made into three concentration, they are 4, 8, and 16%. Activity of hair growth was tested by applying the product on the dorsal site of New Zealand male rabbits divided into six sections of treatment, namely normal, negative (base hair tonic), positive control (Minoxidil) and three concentrations. Hair length measurements performed on days 7th, 14th, 21st, 28th, 35th, and 42nd. Hair thickness was measured by Scanning Electron Microscope (SEM) at week 1st and 6th, while the hair density and weight were measured at weeks 6th. Statistical analysis showed that the concentration of 4% and 16% have an activity equivalent to the positive control, whereas the levels of 8% has weaker activity on density parameter. This hair tonic containing mulberry leaves extract are stable at storage. Skin safety test using Patch test was safe and HET-CAM methode showed mild eye irritation.;A person with lush and healthy hair has a looking good appearance. When hair are lost and were not treated, it can lead to baldness. Mulberry previously known as a skin lightening agent for cosmetic products, traditionally also used for hair growth. The purpose of this research is to analyze the activity of hair growth from hair tonic which contain ethanol extract of mulberry leaves and to obtain a stable and safe hair tonic product. Hair tonic from mulberry leaves was made into three concentration, they are 4, 8, and 16%. Activity of hair growth was tested by applying the product on the dorsal site of New Zealand male rabbits divided into six sections of treatment, namely normal, negative (base hair tonic), positive control (Minoxidil) and three concentrations. Hair length measurements performed on days 7th, 14th, 21st, 28th, 35th, and 42nd. Hair thickness was measured by Scanning Electron Microscope (SEM) at week 1st and 6th, while the hair density and weight were measured at weeks 6th. Statistical analysis showed that the concentration of 4% and 16% have an activity equivalent to the positive control, whereas the levels of 8% has weaker activity on density parameter. This hair tonic containing mulberry leaves extract are stable at storage. Skin safety test using Patch test was safe and HET-CAM methode showed mild eye irritation., A person with lush and healthy hair has a looking good appearance. When hair are lost and were not treated, it can lead to baldness. Mulberry previously known as a skin lightening agent for cosmetic products, traditionally also used for hair growth. The purpose of this research is to analyze the activity of hair growth from hair tonic which contain ethanol extract of mulberry leaves and to obtain a stable and safe hair tonic product. Hair tonic from mulberry leaves was made into three concentration, they are 4, 8, and 16%. Activity of hair growth was tested by applying the product on the dorsal site of New Zealand male rabbits divided into six sections of treatment, namely normal, negative (base hair tonic), positive control (Minoxidil) and three concentrations. Hair length measurements performed on days 7th, 14th, 21st, 28th, 35th, and 42nd. Hair thickness was measured by Scanning Electron Microscope (SEM) at week 1st and 6th, while the hair density and weight were measured at weeks 6th. Statistical analysis showed that the concentration of 4% and 16% have an activity equivalent to the positive control, whereas the levels of 8% has weaker activity on density parameter. This hair tonic containing mulberry leaves extract are stable at storage. Skin safety test using Patch test was safe and HET-CAM methode showed mild eye irritation.] |
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