[ABSTRAK Proporsi kematian karena MDR TB di Rumah Sakit Hasan Sadikin Bandung12,73%. Penelitian ini bertujuan untuk melihat factor factor yang mempengaruhiketahanan hidup pasien MDR TB di Rumah Sakit Hasan Sadikin Bandung.Desain penelitian yang digunakan adalah kohort retrospektif dengan jumlahsampel 216 di mana 80 sebagai event dan sisanya sebagai sensor. Hasil analisisdengan Survival dengan Spss memperlihatkan predictor utama dari ketahananhidup pasien MDR TB di RSHS adalah pola resistensi(HR 0,3 ; 95% CI 0,2-0,5; Pvalue 0,000), efek samping obat berhubungan dengan waktu(HR 1,12; 95% CI1,02-1,22; P value 0,013)dan BMI kurang (HR 1,8; 95%CI 1,02-3,3; P value0,04). Efek samping obat sebelum terapi bulan kedelapan efeknya proteksi,sedangkan sesudah itu meningkatkan resiko kematian. Konfoundingnya adalahriwayat merokok, jenis kelamin, umur dan pekerjaan. Probabilitas ketahananhidup pasien MDR TB 0,56. Oleh sebab itu peningkatan kepatuhan minum obat,konsistennya pengukuran tinggi badan dan berat badan pasien MDR TB danefektivitas manajemen efek samping OAT dapat meningkatkan ketahanan hiduppasien MDR TB di Rumah Sakit Hasan Sadikin Bandung. ABSTRACT Proportion death caused by MDR TB at Hasan Sadikin General Hospital inBandung (RSHS) is 12,73%. This study is observe factors affecting the survival ofpatient with MDR TB at Hasan Sadikin General Hospital Bandung. The studydesign uses retrospective cohorts with sample size 216 patient, whereas 80 ofthem is used as event and the rest is treated as sensor. Survival analysis resultsusing SPSS demonstrated main predictors of survival among MDR TB patient inRSHS, which are : resistancy pattern (HR 0,31; 95%CI 0,2-0,5; P value 0,000),drug side effect with time dependent (HR 1,12; 95%CI 1,02-1,22; P value 0,013),and BMI (HR 1,8; 95% CI 0,2-3,3, P value 0,04). Confounding factors found wassmoking history, sex/gender, age and occupation. The propability of MDR TBpatient?survival is 0,56. Therefore improving drug taking compliance, consistantmonitoring and improvement of BMI as well as management of anti TB drug sideeffect may improve the survival of MDR TB patient at Hasan Sadikin GeneralHospital in Bandung.;Proportion death caused by MDR TB at Hasan Sadikin General Hospital inBandung (RSHS) is 12,73%. This study is observe factors affecting the survival ofpatient with MDR TB at Hasan Sadikin General Hospital Bandung. The studydesign uses retrospective cohorts with sample size 216 patient, whereas 80 ofthem is used as event and the rest is treated as sensor. Survival analysis resultsusing SPSS demonstrated main predictors of survival among MDR TB patient inRSHS, which are : resistancy pattern (HR 0,31; 95%CI 0,2-0,5; P value 0,000),drug side effect with time dependent (HR 1,12; 95%CI 1,02-1,22; P value 0,013),and BMI (HR 1,8; 95% CI 0,2-3,3, P value 0,04). Confounding factors found wassmoking history, sex/gender, age and occupation. The propability of MDR TBpatient?survival is 0,56. Therefore improving drug taking compliance, consistantmonitoring and improvement of BMI as well as management of anti TB drug sideeffect may improve the survival of MDR TB patient at Hasan Sadikin GeneralHospital in Bandung., Proportion death caused by MDR TB at Hasan Sadikin General Hospital inBandung (RSHS) is 12,73%. This study is observe factors affecting the survival ofpatient with MDR TB at Hasan Sadikin General Hospital Bandung. The studydesign uses retrospective cohorts with sample size 216 patient, whereas 80 ofthem is used as event and the rest is treated as sensor. Survival analysis resultsusing SPSS demonstrated main predictors of survival among MDR TB patient inRSHS, which are : resistancy pattern (HR 0,31; 95%CI 0,2-0,5; P value 0,000),drug side effect with time dependent (HR 1,12; 95%CI 1,02-1,22; P value 0,013),and BMI (HR 1,8; 95% CI 0,2-3,3, P value 0,04). Confounding factors found wassmoking history, sex/gender, age and occupation. The propability of MDR TBpatient’survival is 0,56. Therefore improving drug taking compliance, consistantmonitoring and improvement of BMI as well as management of anti TB drug sideeffect may improve the survival of MDR TB patient at Hasan Sadikin GeneralHospital in Bandung.] |