[ABSTRAK
Menstruasi yang menimbulkan nyeri merupakan salah satu masalah ginekologiyang paling umum dialami wanita dari berbagai tingkat usia. Manajemen untukmengatasi nyeri saat haid diantaranya adalah dengan mengonsumsi obat peredanyeri haid. Saat ini masyarakat mulai beralih untuk menggunakan tanaman obatsebagai obat alternatif analgesik, diantaranya tanaman jahe merah merah(Zingiber officinale var. Rubrum) dan cengkeh (Syzigium aromaticum). Penelitianini bertujuan untuk mengetahui pengaruh sediaan krim campuran minyak jahemerah (Zingiber officinale var. Rubrum) dan minyak cengkeh (Syzigiumaromaticum) terhadap penurunan intensitas nyeri haid primer. Minyak jahe merahdan minyak cengkeh dibuat menjadi sediaan krim dengan konsentrasi berturutturut5% dan 3%. Uji stabilitas fisik sediaan krim dilakukan selama 12 minggudan uji keamanan kepada relawan menggunakan metode uji tempel. Uji manfaatdilakukan selama 3 jam pada area abdomen bagian bawah. Sediaan krimmenunjukkan kestabilan selama 12 minggu dan hasil uji keamanan tidakmenimbulkan iritasi sehingga aman digunakan secara topikal. Hasil uji manfaatdiukur dengan parameter Visual Analogue Scale, Wong-Baker Faces Pain RatingScale, frekuensi denyut nadi radialis, frekuensi pernapasan, menunjukkan sediaankrim uji mampu menurunkan intensitas nyeri haid primer. Krim uji memberikanpengaruh penurunan intensitas nyeri yang berbeda nyata dibandingkan krimplasebo, yaitu pada pemakaian krim setelah 3 jam.
ABSTRACT
Painful menstruation is one of the most common gynecological problemsexperienced by women of all ages. To overcome the pain during menstruation isby taking pain medication during menstruation. Nowadays , people are start to useherb as an alternative analgesic medicine, including red ginger plant (Zingiberofficinale var.Rubrum) and cloves (Syzigium aromaticum). This research aims todetermine the effect of mixture cream between red ginger oil (Zingiber officinalevar . Rubrum) and clove oil ( Syzigium aromaticum) to reduce the intensity ofprimary Dysmenorrhea. Oil of red ginger and clove oils are made into cream witha concentration respectively 5% and 3%. Physical stability test for creamsconducted over 12 weeks and safety testing to volunteers using the patch test.Benefit test carried out for 3 hours at the lower abdominal area. Formulationscream showed stability during 12 weeks and the results of safety test does notcause irritation which make safe to use topically. Benefit test results measured byVisual Analogue Scale parameter, Wong- Baker Faces Pain Rating Scale, thefrequency of the radial pulse and respiratory rate, it shows the test cream capableof lowering the intensity of the primary dysmenorrhea. Test creams is able todecrease pain intensity and was significantly different compared to placebo creamwhere each effect of the cream is observed after 3 hours;Painful menstruation is one of the most common gynecological problemsexperienced by women of all ages. To overcome the pain during menstruation isby taking pain medication during menstruation. Nowadays , people are start to useherb as an alternative analgesic medicine, including red ginger plant (Zingiberofficinale var.Rubrum) and cloves (Syzigium aromaticum). This research aims todetermine the effect of mixture cream between red ginger oil (Zingiber officinalevar . Rubrum) and clove oil ( Syzigium aromaticum) to reduce the intensity ofprimary Dysmenorrhea. Oil of red ginger and clove oils are made into cream witha concentration respectively 5% and 3%. Physical stability test for creamsconducted over 12 weeks and safety testing to volunteers using the patch test.Benefit test carried out for 3 hours at the lower abdominal area. Formulationscream showed stability during 12 weeks and the results of safety test does notcause irritation which make safe to use topically. Benefit test results measured byVisual Analogue Scale parameter, Wong- Baker Faces Pain Rating Scale, thefrequency of the radial pulse and respiratory rate, it shows the test cream capableof lowering the intensity of the primary dysmenorrhea. Test creams is able todecrease pain intensity and was significantly different compared to placebo creamwhere each effect of the cream is observed after 3 hours, Painful menstruation is one of the most common gynecological problemsexperienced by women of all ages. To overcome the pain during menstruation isby taking pain medication during menstruation. Nowadays , people are start to useherb as an alternative analgesic medicine, including red ginger plant (Zingiberofficinale var.Rubrum) and cloves (Syzigium aromaticum). This research aims todetermine the effect of mixture cream between red ginger oil (Zingiber officinalevar . Rubrum) and clove oil ( Syzigium aromaticum) to reduce the intensity ofprimary Dysmenorrhea. Oil of red ginger and clove oils are made into cream witha concentration respectively 5% and 3%. Physical stability test for creamsconducted over 12 weeks and safety testing to volunteers using the patch test.Benefit test carried out for 3 hours at the lower abdominal area. Formulationscream showed stability during 12 weeks and the results of safety test does notcause irritation which make safe to use topically. Benefit test results measured byVisual Analogue Scale parameter, Wong- Baker Faces Pain Rating Scale, thefrequency of the radial pulse and respiratory rate, it shows the test cream capableof lowering the intensity of the primary dysmenorrhea. Test creams is able todecrease pain intensity and was significantly different compared to placebo creamwhere each effect of the cream is observed after 3 hours] |
T43642-Fitriani Annisa Al Mansur.pdf :: Unduh