[ABSTRAK
Pendahuluan: Osteopontin merupakan salah satu penanda molekuler hipoksiaendogen tumor. Hipoksia adalah salah satu faktor yang menentukan agresifitaspenyakit. Kadar osteopontin tinggi pada berbagai keganasan termasuk gliomamaligna. Peningkatan kadar osteopontin akan menyebabkan respon terapi berkurang.Penelitian ini bertujuan untuk mengetahui korelasi antara kadar osteopontin praradiasidengan respon radiasi pada glioma maligna.Metode: Penelitian ini merupakan studi retrospektif kohort terhadap 15 pasienmaligna glioma yang menjalani terapi radiasi dari juli 2004 sampai mei 2015 diRSUPN. DR. Cipto Mangunkusumo. Osteopontin diperiksa menggunakan metodeELISA dari sampel parafin blok. Volume tumor dihitung dari CT scan atau MRIberdasarkan pengukuran volume tiga dimensi. Respon tumor dinilai denganmembandingkan volume tumor sebelum dan sesudah radiasi dengan menggunakanCT dan MRI.Hasil: Didapatkan rerata kadar osteopontin sebesar 0,49 ± 0,45 ng/ml, reratapersentase perubahan volume tumor 8,59 ± 54,22 %. Volume tumor yang membesar60%. Tumor yang progresif sebesar 26,7%. Secara keseluruhan terdapat korelasinegatif lemah yang tidak bermakna ( r -0,39 dan p 0,146 ) antara kadar osteopontindengan respon radiasi. Terdapat korelasi positif kuat yang tidak bermakna ( r +0,68dan p 0,219 ) antara kadar osteopontin dengan respon radiasi pada kelompok yangmenggunakan kemosensitizer temozolamide.Kesimpulan: Terdapat korelasi negatif lemah yang tidak bermakna antara kadarosteopontin dengan respon radiasi. Terdapat korelasi positif kuat yang tidakbermakna antara kadar osteopontin dengan respon radiasi pada kelompok yangmenggunakan kemosensitizer temozolamide.
ABSTRACT
Introduction : Osteopontin is an endogenous molecular marker of tumor hypoxia,which is one of factors that determine the aggressiveness of the disease. Increasedlevel of osteopontin will decrease therapeutic response which will eventuallyinfluence the success of therapy.The purpose of this study is to determine thecorrelation between osteopontin level and radiation response in malignant glioma.Method : This is a retrospective cohort study of 15 malignant glioma patients whounderwent radiation from July 2004 to May 2015 at Cipto Mangunkusumo Hospital.Osteopontin level was measured with ELISA from paraffin embedded tissue. Tumorvolume was calculated by measuring three dimensional volume of tumor imagingfrom CT or MRI. Tumor response was evaluated by comparing pre-irradiation withpost-irradiation tumor volume seen in CT and MRI.Result : The mean osteopontin level was 0.49 ± 0.45 ng/ml and the mean percentageof change in tumor volume was 8.59 ± 54.22 %. Enlargement of tumor volume was60 %. Progressive disease was found in 26.7 % of patients. Overall, there was aninsignificant weak negative correlation (r -0.39 and p 0.146) between level ofosteopontin and radiation response. There was an insignificant strong positivecorrelation (r +0.68 and p 0.219) between level of osteopontin and radiation responsein the group that received radiation therapy concurrent with temozolamide.Conclusion : Overall, there was an insignificant weak negative correlation betweenlevel of osteopontin and radiation response. In the group that received radiationtherapy concurrent with temozolamide, there was an insignificant strong positivecorrelation between level of osteopontin and radiation response, Introduction : Osteopontin is an endogenous molecular marker of tumor hypoxia,which is one of factors that determine the aggressiveness of the disease. Increasedlevel of osteopontin will decrease therapeutic response which will eventuallyinfluence the success of therapy.The purpose of this study is to determine thecorrelation between osteopontin level and radiation response in malignant glioma.Method : This is a retrospective cohort study of 15 malignant glioma patients whounderwent radiation from July 2004 to May 2015 at Cipto Mangunkusumo Hospital.Osteopontin level was measured with ELISA from paraffin embedded tissue. Tumorvolume was calculated by measuring three dimensional volume of tumor imagingfrom CT or MRI. Tumor response was evaluated by comparing pre-irradiation withpost-irradiation tumor volume seen in CT and MRI.Result : The mean osteopontin level was 0.49 ± 0.45 ng/ml and the mean percentageof change in tumor volume was 8.59 ± 54.22 %. Enlargement of tumor volume was60 %. Progressive disease was found in 26.7 % of patients. Overall, there was aninsignificant weak negative correlation (r -0.39 and p 0.146) between level ofosteopontin and radiation response. There was an insignificant strong positivecorrelation (r +0.68 and p 0.219) between level of osteopontin and radiation responsein the group that received radiation therapy concurrent with temozolamide.Conclusion : Overall, there was an insignificant weak negative correlation betweenlevel of osteopontin and radiation response. In the group that received radiationtherapy concurrent with temozolamide, there was an insignificant strong positivecorrelation between level of osteopontin and radiation response] |
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