:: eBooks :: Kembali

eBooks :: Kembali

Endocrine FGFs and klothos

Makoto Kuro-o ([, Springer], 2012)

 Abstrak

Fibroblast growth factors (FGFs) have been recognized primarily as autocrine/paracrine factors that regulate embryonic development and organogenesis. However, recent studies have revealed that some FGFs function as endocrine factors and regulate various metabolic processes in adulthood. Such FGFs, collectively called endocrine FGFs, are comprised of three members (FGF15/19, FGF21, and FGF23: FGF15 is the mouse ortholog of human FGF19). These endocrine FGFs share a common structural feature that enables the endocrine mode of action at the expense of the affinity to FGF receptors. To restore the affinity to FGF receptors in their target organs, the endocrine FGFs have designated the Klotho family of transmembrane proteins as obligate co-receptors. By expressing Klothos in a tissue-specific manner, this unique co-receptor system also enables the endocrine FGFs to specify their target organs among many tissues that express FGF receptors.

 File Digital: 1

Shelf
 Endocrine FGFs and Klothos.pdf :: Unduh

LOGIN required

 Metadata

No. Panggil : e20417662
Entri utama-Nama orang :
Entri tambahan-Nama orang :
Subjek :
Penerbitan : New York: [, Springer], 2012
Sumber Pengatalogan: LibUI eng rda
Tipe Konten: text
Tipe Media: computer
Tipe Pembawa: online resource
Deskripsi Fisik:
Tautan: http://link.springer.com/book/10.1007%2F978-1-4614-0887-1
Lembaga Pemilik:
Lokasi:
  • Ketersediaan
  • Ulasan
No. Panggil No. Barkod Ketersediaan
e20417662 TERSEDIA
Ulasan:
Tidak ada ulasan pada koleksi ini: 20417662