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[Pemberian terapi yang sesuai, khususnya obat antiepilepsi (OAE) sebagai terapiutama dapat menyembuhkan pasien penyandang epilepsi.Seringkali faktor yangberkaitan erat dengan pemberian OAE kurang diperhatikan.Oleh karena itu,penelitian yang dilakukan penulis membahas bagaimana hubungan antara faktorfaktoryang memengaruhi respons terapi pada anak penyandangepilepsi.Penelitian dilakukan dengan metode cross-sectional, yaitu denganmenggunakan data sekunder dari rekam medis epilepsy registry pada pasien anakdi Departemen Ilmu Kesehatan Anak RSUPN Cipto Mangunkusumo dengantanggal kunjungan 1995-2010. Dari penelitian, ditemukan bahwa dari 174 subyekpenelitian, 76,4% mengalami bangkitan umum dan 23,6% mengalami bangkitanfokal. Terdapat 62,1% subyek yang mengalami epilepsi simtomatik dan 37,9%epilepsi idiopatik. Sembilan puluh enam koma enam persen subyek mendapatkanregimen yang sesuai dengan lini pertama, 63,8% mendapatkan OAE dengan dosissesuai, 77,0% subyek mendapatkan terapi tunggal (monoterapi), dan 70,3% tidakmengalami perubahan regimen selama terapi. Dari analisis bivariat menggunakanuji Chi-Square maupun Fisher?s, tidak ditemukan hubungan yang signifikan baikuntuk faktor kesesuaian regimen, dosis OAE, kombinasi OAE, maupun perubahanregimen selama terapi (seluruhnya memiliki nilai p > 0,05). Namun, nilai ORmasing-masing faktor menunjukkan hasil yang sesuai dengan teori sehingga dapatdisimpulkan bahwa secara klinis respons bebas kejang akan didapatkan padapasien yang mendapatkan regimen sesuai, dosis sesuai, monoterapi, dan tidak adapergantian regimen. Adapun bila dikaitkan dengan klasifikasi epilepsi yangdialami, pasien dengan epilepsi idiopatik memiliki kecenderungan mendapatkanrespons bebas kejang (OR=1,407 95%CI 0,732-2,705). Analisis multivariatmenggunakan uji regresi logistik menunjukkan monoterapi menjadi faktor yangterkuat dalam pencapaian respons terapi epilepsi walaupun hasil pada penelitianini tidak signifikan.;Appropiate therapy admission, especially antiepileptic drugs (AED) as the maintherapy for epileptic patients, might help the patients to achieve its maximumrecovery. Health care providers don?t pay much attention to factors related toAED admission. Therefore, this research was determined to analyze theassociation between several factors affecting treatment response in children withepilepsy. This research is a cross-sectional study, using secondary data fromepilepsy registry medical record in pediatric patient at Pediatric HealthDepartment of RSUPN Cipto Mangunkusumo during 1995-2010. This studyshowed that among 174 subjects, 76.4% subjects had general seizure and 23.6%subjects had focal seizure. It is also found that 62.1% subjects had symptomaticepilepsy and 37.9% subjects had idiophatic epilepsy. Ninety six point six percentsubjects had appropriate regiment with first-line drugs, 63.8% subjects hadappropriate AED dose, 77.0% subjects received monotherapy, and 70.3% did notreceive any regiment modification during therapy. Through bivariate analysisusing Chi-Square and Fisher?s test: there were no significant association betweenregiment compatibility, AED dose, AED combination, and regiment modificationduring therapy (p > 0.05). However, the odds ratio (OR) of each factors showedcorresponding result with the theory. In conclusion, seizure-free response will beachieved by patients who had appropriate regiment, appropriate dose,monotherapy, and no regiment modification. Analysis about association betweenepilepsy classification and therapy response showed that patient with idiophaticepilepsy tended to be easier to be seizure-free. Multivariate analysis using logisticregression showed that monotherapy was the strongest factor affecting therapyresponse, even though in this study it was not statistically significant;Appropiate therapy admission, especially antiepileptic drugs (AED) as the maintherapy for epileptic patients, might help the patients to achieve its maximumrecovery. Health care providers don?t pay much attention to factors related toAED admission. Therefore, this research was determined to analyze theassociation between several factors affecting treatment response in children withepilepsy. This research is a cross-sectional study, using secondary data fromepilepsy registry medical record in pediatric patient at Pediatric HealthDepartment of RSUPN Cipto Mangunkusumo during 1995-2010. This studyshowed that among 174 subjects, 76.4% subjects had general seizure and 23.6%subjects had focal seizure. It is also found that 62.1% subjects had symptomaticepilepsy and 37.9% subjects had idiophatic epilepsy. Ninety six point six percentsubjects had appropriate regiment with first-line drugs, 63.8% subjects hadappropriate AED dose, 77.0% subjects received monotherapy, and 70.3% did notreceive any regiment modification during therapy. Through bivariate analysisusing Chi-Square and Fisher?s test: there were no significant association betweenregiment compatibility, AED dose, AED combination, and regiment modificationduring therapy (p > 0.05). However, the odds ratio (OR) of each factors showedcorresponding result with the theory. In conclusion, seizure-free response will beachieved by patients who had appropriate regiment, appropriate dose,monotherapy, and no regiment modification. Analysis about association betweenepilepsy classification and therapy response showed that patient with idiophaticepilepsy tended to be easier to be seizure-free. Multivariate analysis using logisticregression showed that monotherapy was the strongest factor affecting therapyresponse, even though in this study it was not statistically significant, Appropiate therapy admission, especially antiepileptic drugs (AED) as the maintherapy for epileptic patients, might help the patients to achieve its maximumrecovery. Health care providers don’t pay much attention to factors related toAED admission. Therefore, this research was determined to analyze theassociation between several factors affecting treatment response in children withepilepsy. This research is a cross-sectional study, using secondary data fromepilepsy registry medical record in pediatric patient at Pediatric HealthDepartment of RSUPN Cipto Mangunkusumo during 1995-2010. This studyshowed that among 174 subjects, 76.4% subjects had general seizure and 23.6%subjects had focal seizure. It is also found that 62.1% subjects had symptomaticepilepsy and 37.9% subjects had idiophatic epilepsy. Ninety six point six percentsubjects had appropriate regiment with first-line drugs, 63.8% subjects hadappropriate AED dose, 77.0% subjects received monotherapy, and 70.3% did notreceive any regiment modification during therapy. Through bivariate analysisusing Chi-Square and Fisher’s test: there were no significant association betweenregiment compatibility, AED dose, AED combination, and regiment modificationduring therapy (p > 0.05). However, the odds ratio (OR) of each factors showedcorresponding result with the theory. In conclusion, seizure-free response will beachieved by patients who had appropriate regiment, appropriate dose,monotherapy, and no regiment modification. Analysis about association betweenepilepsy classification and therapy response showed that patient with idiophaticepilepsy tended to be easier to be seizure-free. Multivariate analysis using logisticregression showed that monotherapy was the strongest factor affecting therapyresponse, even though in this study it was not statistically significant] |
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