[ABSTRAK Latar Belakang:Pada tahun 1998-1999, kesintasan pasien karsinoma hepatoselular (KHS) yangberobat di Rumah Sakit Cipto Mangunkusumo (RSCM) sangat rendah karenasebagian besar datang dalam stadium lanjut dan hanya sedikit pasien yang dapatmemperoleh terapi paliatif atau kuratif. Dalam tiga tahun terakhir, RSCM telahmemiliki fasilitas tatalaksana KHS yang lebih baik, namun dampaknya terhadapperbaikan kesintasan pasien KHS belum diketahui.Tujuan:Mengetahui perbandingan kesintasan satu tahun pasien KHS yang berobat diRSCM pada periode 2013-2014 dengan periode 1998-1999.Metode:Data 114 pasien KHS yang berobat di RSCM pada periode 2013-2014 dan datasekunder penelitian 77 pasien KHS di RSCM pada tahun 1998-1999 dikumpulkansecara retrospektif lalu dilakukan penilaian karakteristik dan perbandingan kurvakesintasan dengan menggunakan metode Kaplan-Meier yang dilanjutkan denganuji log-rank.Hasil:Terdapat peningkatan hepatitis B sebagai etiologi KHS dari 32,5% pada 1998-1999 menjadi 67,5% pada 2013-2014. Insidens pasien yang meninggal selamapengamatan adalah 57% (95% interval kepercayaan (IK) = 48-66%) pada periode2013-2014 dan 61% (95% IK = 49-73%) pada periode 1998-1999. Mediankesintasan secara keseluruhan adalah 141 hari. Meskipun terdapat perbaikandalam fasilitas tatalaksana KHS, angka kesintasan satu tahun pada kedua periodetidak berbeda secara signifikan (29,4% pada 2013-2014 dan 24,1% pada 1998-1999, p=0,913). Hal ini tampaknya disebabkan karena surveilans KHS padapopulasi risiko tinggi masih rendah.Simpulan:Tidak ada perbedaan kesintasan satu tahun pasien KHS pada periode 2013-2014dengan periode 1998-1999. ABSTRACT Background:In 1998-1999, the survival of hepatocellular carcinoma (HCC) patients in CiptoMangunkusumo Hospital was very poor because most patients came in advancedstage and only few patients could receive palliative or curative treatment. In thelast three years, Cipto Mangunkusumo Hospital has improved its facilities forHCC treatment. It is unclear whether this effort has resulted in improvement ofpatients? survival.Objectives:To compare one-year survival rate of HCC patients between two periods (2013-2014 and 1998-1999).Method:We analyzed retrospectively 114 HCC patients who came to our department in2013-2014 and 77 patients in 1998-1999. We compare the clinical characteristicsand treatment between two periods and then we analyze the survival of bothgroups using Kaplan-Meier method and compare them using log-rank test.Results:There was an increase in hepatitis B prevalence as the etiology of HCC from32,5% in 1998-1999 to 67,5% in 2013-2014, causing hepatitis B as the mainetiology of HCC in 2013-2014. Incidence rate of patients who died in 2013-2014was 57% (95% confidence interval (CI) = 48-66%) and in 1998-1999 was 61%(95% CI = 49-73%). Overall median survival was 141 days. Despite improvementin treatment facilities, no significant difference was found in one-year survivalrate (29,4% in 2013-2014 versus 24,1% in 1998-1999, p=0,913). It seems thatthis result was caused by low level of surveillance in high-risk population.Conclusion:No improvement was seen in one-year survival rate of HCC patients between2013-2014 and 1998-1999.;Background:In 1998-1999, the survival of hepatocellular carcinoma (HCC) patients in CiptoMangunkusumo Hospital was very poor because most patients came in advancedstage and only few patients could receive palliative or curative treatment. In thelast three years, Cipto Mangunkusumo Hospital has improved its facilities forHCC treatment. It is unclear whether this effort has resulted in improvement ofpatients? survival.Objectives:To compare one-year survival rate of HCC patients between two periods (2013-2014 and 1998-1999).Method:We analyzed retrospectively 114 HCC patients who came to our department in2013-2014 and 77 patients in 1998-1999. We compare the clinical characteristicsand treatment between two periods and then we analyze the survival of bothgroups using Kaplan-Meier method and compare them using log-rank test.Results:There was an increase in hepatitis B prevalence as the etiology of HCC from32,5% in 1998-1999 to 67,5% in 2013-2014, causing hepatitis B as the mainetiology of HCC in 2013-2014. Incidence rate of patients who died in 2013-2014was 57% (95% confidence interval (CI) = 48-66%) and in 1998-1999 was 61%(95% CI = 49-73%). Overall median survival was 141 days. Despite improvementin treatment facilities, no significant difference was found in one-year survivalrate (29,4% in 2013-2014 versus 24,1% in 1998-1999, p=0,913). It seems thatthis result was caused by low level of surveillance in high-risk population.Conclusion:No improvement was seen in one-year survival rate of HCC patients between2013-2014 and 1998-1999.;Background:In 1998-1999, the survival of hepatocellular carcinoma (HCC) patients in CiptoMangunkusumo Hospital was very poor because most patients came in advancedstage and only few patients could receive palliative or curative treatment. In thelast three years, Cipto Mangunkusumo Hospital has improved its facilities forHCC treatment. It is unclear whether this effort has resulted in improvement ofpatients? survival.Objectives:To compare one-year survival rate of HCC patients between two periods (2013-2014 and 1998-1999).Method:We analyzed retrospectively 114 HCC patients who came to our department in2013-2014 and 77 patients in 1998-1999. We compare the clinical characteristicsand treatment between two periods and then we analyze the survival of bothgroups using Kaplan-Meier method and compare them using log-rank test.Results:There was an increase in hepatitis B prevalence as the etiology of HCC from32,5% in 1998-1999 to 67,5% in 2013-2014, causing hepatitis B as the mainetiology of HCC in 2013-2014. Incidence rate of patients who died in 2013-2014was 57% (95% confidence interval (CI) = 48-66%) and in 1998-1999 was 61%(95% CI = 49-73%). Overall median survival was 141 days. Despite improvementin treatment facilities, no significant difference was found in one-year survivalrate (29,4% in 2013-2014 versus 24,1% in 1998-1999, p=0,913). It seems thatthis result was caused by low level of surveillance in high-risk population.Conclusion:No improvement was seen in one-year survival rate of HCC patients between2013-2014 and 1998-1999., Background:In 1998-1999, the survival of hepatocellular carcinoma (HCC) patients in CiptoMangunkusumo Hospital was very poor because most patients came in advancedstage and only few patients could receive palliative or curative treatment. In thelast three years, Cipto Mangunkusumo Hospital has improved its facilities forHCC treatment. It is unclear whether this effort has resulted in improvement ofpatients? survival.Objectives:To compare one-year survival rate of HCC patients between two periods (2013-2014 and 1998-1999).Method:We analyzed retrospectively 114 HCC patients who came to our department in2013-2014 and 77 patients in 1998-1999. We compare the clinical characteristicsand treatment between two periods and then we analyze the survival of bothgroups using Kaplan-Meier method and compare them using log-rank test.Results:There was an increase in hepatitis B prevalence as the etiology of HCC from32,5% in 1998-1999 to 67,5% in 2013-2014, causing hepatitis B as the mainetiology of HCC in 2013-2014. Incidence rate of patients who died in 2013-2014was 57% (95% confidence interval (CI) = 48-66%) and in 1998-1999 was 61%(95% CI = 49-73%). Overall median survival was 141 days. Despite improvementin treatment facilities, no significant difference was found in one-year survivalrate (29,4% in 2013-2014 versus 24,1% in 1998-1999, p=0,913). It seems thatthis result was caused by low level of surveillance in high-risk population.Conclusion:No improvement was seen in one-year survival rate of HCC patients between2013-2014 and 1998-1999.] |