ABSTRAK
Latar belakang: Konstipasi fungsional kronik adalah masalah yang seringditemukan di masyarakat dengan prevalensi sekitar 15-25%. Konstipasimenimbulkan berbagai gejala, meningkatkan angka kesakitan dan biaya kesehatan.Saat ini, penggunaan probiotik untuk pengobatan konstipasi kronik pada dewasatelah diteliti, namun, dari berbagai penelitian yang telah dilakukan hasil yangdiperoleh masih terbatas dan menimbulkan kontroversi.Tujuan: Untuk menilai manfaat Lactobacillus reuteri dalam memperbaiki skorkonstipasi Agachan, jumlah L. reuteri feses dan pH feses pada pasien konstipasifungsional kronik.Metode: Uji acak tersamar ganda dilakukan pada 40 pasien dewasa (12 laki-laki/28 perempuan), rerata usia 45,95+/-16 tahun, yang menderita konstipasi fungsionalkronik sesuai kriteria Rome III, selanjutnya dilakukan randomisasi dan diberikanL.reuteri atau Plasebo selama 4 minggu.Hasil: Pada minggu ke-4, setelah pemberian L.reuteri terjadi perbaikan gejalakonstipasi, yang dinilai dari penurunan skor konstipasi Agachan dari 17 menjadi 8dengan p <0.001. Terjadi peningkatan jumlah L.reuteri feses dari 6,80x10 menjadi 2,12x10 8 dengan p <0,001 dan penurunan pH feses dari 5,44 (SB 0,70) menjadi4,78 (SB 0,56) dengan p <0,001 pada kelompok L.reuteri, sedangkan padakelompok Plasebo tidak didapatkan hasil yang bermakna pada perbaikan skorkonstipasi Agachan, jumlah L.reuteri feses dan pH feses.Kesimpulan: L.reuteri lebih efektif dibandingkan Plasebo dalam memperbaikikonstipasi, meningkatkan jumlah L.reuteri feses dan menurunkan pH feses padapasien konstipasi fungsional kronik dewasa.
ABSTRACT
Background: Chronic functional constipation is a common problem that affectsbetween 15-25% of the population and cause symptoms and disorders, that createsdiscomfort, morbidity and high costs for health care. Recently, the consumption ofprobiotics in treating chronic constipation in adults have been investigated.However, there are still limited and controversial evidences available fromcontrolled trials.Aim: To evaluate the effects of L. reuteri in improving the Agachan constipationscore, the number of L. reuteri in the feces and the fecal pH in the patients withchronic functional constipation.Methods: A double-blind, placebo RCT was conducted in 40 adult (12 male/ 28female with mean age 45,95+/-16 years) affected by chronic functional constipationaccording to Rome III criteria. Patients were randomly assigned to receive asupplementation of L.reuteri or Placebo for 4 weeks.Results: At week 4, the decrease in Agachan constipation score was from 17.00 to8.00 with p <0.001, the increase number of L.reuteri was from 6,80x10with p <0,001 and the decrease of pH feces was from 5,44 (SB 0,70) to 4,78 (SB0,56) with p <0,001 in the L. reuteri group, otherwise in the Placebo group therewere no significant results in Agachan constipation score, the number of L.reuteriand fecal pH assessed.Conclusion: L.reuteri is more effective than the Placebo group in improving theAgachan constipation score, increasing the number of L. reuteri in the feces anddecreasing the fecal pH in adult with chronic functional constipation.;Background: Chronic functional constipation is a common problem that affectsbetween 15-25% of the population and cause symptoms and disorders, that createsdiscomfort, morbidity and high costs for health care. Recently, the consumption ofprobiotics in treating chronic constipation in adults have been investigated.However, there are still limited and controversial evidences available fromcontrolled trials.Aim: To evaluate the effects of L. reuteri in improving the Agachan constipationscore, the number of L. reuteri in the feces and the fecal pH in the patients withchronic functional constipation.Methods: A double-blind, placebo RCT was conducted in 40 adult (12 male/ 28female with mean age 45,95+/-16 years) affected by chronic functional constipationaccording to Rome III criteria. Patients were randomly assigned to receive asupplementation of L.reuteri or Placebo for 4 weeks.Results: At week 4, the decrease in Agachan constipation score was from 17.00 to8.00 with p <0.001, the increase number of L.reuteri was from 6,80x10with p <0,001 and the decrease of pH feces was from 5,44 (SB 0,70) to 4,78 (SB0,56) with p <0,001 in the L. reuteri group, otherwise in the Placebo group therewere no significant results in Agachan constipation score, the number of L.reuteriand fecal pH assessed.Conclusion: L.reuteri is more effective than the Placebo group in improving theAgachan constipation score, increasing the number of L. reuteri in the feces anddecreasing the fecal pH in adult with chronic functional constipation.;Background: Chronic functional constipation is a common problem that affectsbetween 15-25% of the population and cause symptoms and disorders, that createsdiscomfort, morbidity and high costs for health care. Recently, the consumption ofprobiotics in treating chronic constipation in adults have been investigated.However, there are still limited and controversial evidences available fromcontrolled trials.Aim: To evaluate the effects of L. reuteri in improving the Agachan constipationscore, the number of L. reuteri in the feces and the fecal pH in the patients withchronic functional constipation.Methods: A double-blind, placebo RCT was conducted in 40 adult (12 male/ 28female with mean age 45,95+/-16 years) affected by chronic functional constipationaccording to Rome III criteria. Patients were randomly assigned to receive asupplementation of L.reuteri or Placebo for 4 weeks.Results: At week 4, the decrease in Agachan constipation score was from 17.00 to8.00 with p <0.001, the increase number of L.reuteri was from 6,80x10with p <0,001 and the decrease of pH feces was from 5,44 (SB 0,70) to 4,78 (SB0,56) with p <0,001 in the L. reuteri group, otherwise in the Placebo group therewere no significant results in Agachan constipation score, the number of L.reuteriand fecal pH assessed.Conclusion: L.reuteri is more effective than the Placebo group in improving theAgachan constipation score, increasing the number of L. reuteri in the feces anddecreasing the fecal pH in adult with chronic functional constipation. |
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