ABSTRAK
Latar Belakang. Kemajuan dalam penanganan bayi prematur menyebabkan angka kesintasan meningkat. Akibatnya, angka kesakitan bayi prematur jugameningkat, salah satunya adalah osteopenia of prematurity (OOP). Pemeriksaankadar kalsium, fosfat, dan fosfatase alkali serum saat usia kronologis 4 minggudigunakan sebagai indikator awal sebelum osteopenia tampak secara klinis.Diagnosis sedini mungkin dan pengendalian faktor risiko perlu dilakukansehingga komplikasi dapat dicegah.Tujuan. Mengetahui prevalens dan faktor risiko terjadinya OOP.Desain Penelitian. Penelitian dengan desain potong lintang ini dilaksanakanpada bayi prematur dengan usia gestasi ≤32 minggu di Divisi Perinatalogi RS Dr.Cipto Mangunkusumo. Subyek diperiksa kadar kalsium serum, fosfat inorganikserum, dan fosfatase alkali serum. Pada subyek dilakukan pencatatan faktor risikoOOP untuk menilai hubungan antar variabel dan dilakukan analisis bivariatdengan uji chi square. Hasil Penelitian. Terdapat 80 subyek yang memenuhi kriteria penelitian.Delapan dari 80 subyek (10%) ditemukan menderita OOP. Faktor risiko yangdianalisis dalam penelitian ini ditemukan tidak memiliki hubungan bermaknadengan kejadian OOP, yakni lama penggunaan nutrisi parenteral total (p=0,457),lama penggunaan metilsantin (p=1,000), berat lahir (p=0,459), preeklampsiaberat pada ibu (p=0,344), korioamnionitis pada ibu (p=0,261), dan pemberiannutrisi enteral (p=0,797).Simpulan. Prevalens OOP di RS Dr. Cipto Mangunkusumo adalah 10%. Faktorlama penggunaan nutrisi parenteral total, penggunaan metilsantin, berat lahir,preeklampsia berat pada ibu, korioamnionitis, dan pemberian nutrisi enteral tidak memiliki hubungan bermakna dengan kejadian OOP.ABSTRACT
Background. Advances in management of premature infants had increased the survival rate of these infants. However there is also increase of morbidity such as osteopenia of prematurity (OOP). Laboratory examination of serum calcium,phosphate, and alkaline phosphatase at the chronological age of 4 weeks is usedas early indicator before osteopenia become clinically appearant. Early diagnosisand risk control are needed to prevent complication. Objective. To evaluate the prevalence and risk factors of OOP.Methods. A cross sectional study was done in premature infants <32 weeks ofgestational age in Perinatalogy Division of Cipto Mangunkusumo Hospital.Laboratory examination of serum calcium, phosphate, and alkalinephosphatasewere conducted toward these subjects. Risk factors of OOP were alsoevaluated. Bivariat analysis was analysed by chi square test.Results. There are 80 subjects who meet the study criteria. Eight of 80 subjects(10%) was diagnosed as OOP. No risk factors have significant relationship withOOP incidence, which include duration of total parenteral nutrition (p=0,457),duration of methylxanthine usage (p=1,000), birth weight (p=0,459), severepreecalampsia in the mother (p=0,344), chorioamnionitis in the mother(p=0,261), and enteral nutrition (p=0,797).Conclusion. Prevalence of OOP in Cipto Mangunkusumo Hospital is 10%. Thereare no significant relationship between OOP incidence and duration of totalparenteral nutrition, methylxanthine usage, birth weight, severe preeclampsia in the mother, chorioamnionitis, and enteral nutrition.;Background. Advances in management of premature infants had increased the survival rate of these infants. However there is also increase of morbidity such as osteopenia of prematurity (OOP). Laboratory examination of serum calcium,phosphate, and alkaline phosphatase at the chronological age of 4 weeks is usedas early indicator before osteopenia become clinically appearant. Early diagnosisand risk control are needed to prevent complication. Objective. To evaluate the prevalence and risk factors of OOP.Methods. A cross sectional study was done in premature infants <32 weeks ofgestational age in Perinatalogy Division of Cipto Mangunkusumo Hospital.Laboratory examination of serum calcium, phosphate, and alkalinephosphatasewere conducted toward these subjects. Risk factors of OOP were alsoevaluated. Bivariat analysis was analysed by chi square test.Results. There are 80 subjects who meet the study criteria. Eight of 80 subjects(10%) was diagnosed as OOP. No risk factors have significant relationship withOOP incidence, which include duration of total parenteral nutrition (p=0,457),duration of methylxanthine usage (p=1,000), birth weight (p=0,459), severepreecalampsia in the mother (p=0,344), chorioamnionitis in the mother(p=0,261), and enteral nutrition (p=0,797).Conclusion. Prevalence of OOP in Cipto Mangunkusumo Hospital is 10%. Thereare no significant relationship between OOP incidence and duration of totalparenteral nutrition, methylxanthine usage, birth weight, severe preeclampsia in the mother, chorioamnionitis, and enteral nutrition. |
SP-Nathalia Ningrum.pdf :: Unduh