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UI - Tugas Akhir :: Kembali

Perbandingan efektivitas injeksi intravitreal vorikonazol 100 µg dengan amfoterisin B 5 µg pada endoftalmitis akibat aspergillus flavus : Uji hewan coba kelinci = Comparison of intravitreal antifungal of 100 µg voriconazole and 5 µg amphotericin B in experimental aspergillus flavus endophthalmitis model in rabbits

Alia Arianti; Made Susiyanti, supervisor; Rianto Setiabudy, supervisor; Anna Rozaliyani, supervisor; Siregar, Nuryati Chairani, supervisor (Fakultas Kedokteran Universitas Indonesia, 2015)

 Abstrak

ABSTRAK
Tesis ini bertujuan menilai perbandingan efektivitas injeksi intravitreal
vorikonazol 100 µg/0.1 mL dengan amfoterisin B 5 µg/0.1 mL pada endoftalmitis
akibat Aspergillus flavus di hewan coba kelinci. Uji eksperimental tersamar acak
dilakukan pada 15 kelinci albino New Zealand white yang terbagi menjadi tiga
kelompok, yaitu kelompok vorikonazol, amfoterisin B, dan kontrol. Parameter
yang dinilai adalah perubahan klinis, pemeriksaan mikologi, dan perubahan
histopatologi jaringan. Perubahan skor klinis di akhir evaluasi tidak berbeda
bermakna antara kelompok vorikonazol dengan amfoterisin B, namun respons
klinis cenderung lebih baik pada kelompok vorikonazol. Jumlah koloni jamur
terkecil dan berbeda bermakna didapatkan pada kelompok amfoterisin B. Tidak
didapatkan perbedaan bermakna pada rerata nilai histopatologi jaringan kedua
kelompok, namun derajat inflamasi cenderung lebih ringan pada kelompok vorikonazol.ABSTRACT
The purpose of this study was to compare the efficacies of intravitreal 100 µg voriconazole and 5 µg amphotericin B treatment against Aspergillus flavus in an
exogenous endophthalmitis model in rabbit eyes. A randomized, controlledexperimental
study was conducted on 15 albino New Zealand white rabbits, which latter allocated into three different
treatment group of voriconazole, amphotericin B, and control. Clinical grading were performed at multiple times, while mycology analysis and histopathological examination were performed at 10 days
after treatment. No significant change in clinical grading was found between the
treatment group, but voriconazole group showed better response tendency. The smallest number of fungal colony forming unit was found significantly in the
amphotericin B group. No significant difference was found, however, between the mean histopathological score of the two treatment groups, but the tendency of a lower inflammation score was shown in voriconazole group. ;The purpose of this study was to compare the efficacies of intravitreal 100 µg
voriconazole and 5 µg amphotericin B treatment against Aspergillus flavus in an
exogenous endophthalmitis model in rabbit eyes. A randomized, controlledexperimental
study
was
conducted
on
15
albino
New
Zealand
white
rabbits,
which
latter
allocated
into
three
different
treatment
group
of
voriconazole,
amphotericin
B,
and control. Clinical grading were performed at multiple times, while
mycology analysis and histopathological examination were performed at 10 days
after treatment. No significant change in clinical grading was found between the
treatment group, but voriconazole group showed better response tendency. The
smallest number of fungal colony forming unit was found significantly in the
amphotericin B group. No significant difference was found, however, between the
mean histopathological score of the two treatment groups, but the tendency of a lower inflammation score was shown in voriconazole group. ;The purpose of this study was to compare the efficacies of intravitreal 100 µg
voriconazole and 5 µg amphotericin B treatment against Aspergillus flavus in an
exogenous endophthalmitis model in rabbit eyes. A randomized, controlledexperimental
study
was
conducted
on
15
albino
New
Zealand
white
rabbits,
which
latter
allocated
into
three
different
treatment
group
of
voriconazole,
amphotericin
B,
and control. Clinical grading were performed at multiple times, while
mycology analysis and histopathological examination were performed at 10 days
after treatment. No significant change in clinical grading was found between the
treatment group, but voriconazole group showed better response tendency. The
smallest number of fungal colony forming unit was found significantly in the
amphotericin B group. No significant difference was found, however, between the
mean histopathological score of the two treatment groups, but the tendency of a lower inflammation score was shown in voriconazole group. ;The purpose of this study was to compare the efficacies of intravitreal 100 µg
voriconazole and 5 µg amphotericin B treatment against Aspergillus flavus in an
exogenous endophthalmitis model in rabbit eyes. A randomized, controlledexperimental
study
was
conducted
on
15
albino
New
Zealand
white
rabbits,
which
latter
allocated
into
three
different
treatment
group
of
voriconazole,
amphotericin
B,
and control. Clinical grading were performed at multiple times, while
mycology analysis and histopathological examination were performed at 10 days
after treatment. No significant change in clinical grading was found between the
treatment group, but voriconazole group showed better response tendency. The
smallest number of fungal colony forming unit was found significantly in the
amphotericin B group. No significant difference was found, however, between the
mean histopathological score of the two treatment groups, but the tendency of a lower inflammation score was shown in voriconazole group.

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 Metadata

No. Panggil : SP-PDF
Entri utama-Nama orang :
Entri tambahan-Nama orang :
Entri tambahan-Nama badan :
Subjek :
Penerbitan : [Place of publication not identified]: Fakultas Kedokteran Universitas Indonesia, 2015
Program Studi :
Bahasa : ind
Sumber Pengatalogan : LibUI ind rda
Tipe Konten : text
Tipe Media : computer
Tipe Carrier : online resource
Deskripsi Fisik : xiii, 91 pages : illustration + appendix
Naskah Ringkas :
Lembaga Pemilik : Universitas Indonesia
Lokasi : Perpustakaan UI, Lantai 3
  • Ketersediaan
  • Ulasan
No. Panggil No. Barkod Ketersediaan
SP-PDF 16-18-980018714 TERSEDIA
Ulasan:
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