Gambaran kadar fibrin monomer pada gestational hypertension dan preeklampsia = Description of fibrin monomer levels in gestational hypertension and preeclampsia
Wilia Candra;
Diana Aulia, supervisor; Kanadi Sumapradja, supervisor; Arini Setiawati, supervisor
(Fakultas Kedokteran Universitas Indonesia, 2016)
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ABSTRAK Hipertensi merupakan kelainan yang umum dijumpai pada kehamilan.Sekitar 70% wanita hamil mengalami gestational hypertension dan preeklampsia.Disfungsi endotel pada preeklampsia menyebabkan permukaan endotel yangnontrombogenik menjadi trombogenik sehingga dapat terjadi aktivasi koagulasi.Preeklampsia meningkatkan keadaan hiperkoagulabel yang sudah ada padakehamilan normal. Gestational hypertension pada wanita hamil adalah hipertensiyang tidak memenuhi kriteria preeklampsia. Hampir setengah dari pasien dengangestational hypertension akan berkembang menjadi preeklampsia. Fibrinmonomer merupakan petanda aktivasi koagulasi yang digunakan pada keadaan pretrombotik oleh karena terbentuk terlebih dahulu pada keadaan hiperkoagulabel daripada D-dimer yang terbentuk setelah fibrinolisis. Tujuan penelitian adalahmendapatkan gambaran fibrin monomer pada gestational hypertension danpreeklampsia. Penelitian ini adalah penelitian potong lintang pada 30 wanitahamil gestational hypertension dan 30 wanita hamil preeklampsia yang dilakukanpada Oktober sampai November 2015. Pemeriksaan FM menggunakan reagenSTA-Liatest memakai koagulometer STA Compact Analyzer. Kadar fibrinmonomer pada gestational hypertension didapatkan mean 4,61 µg/mL denganstandar deviasi 0,86 µg/mL. Kadar fibrin monomer pada preeklampsia didapatkanmedian 10,5 µg/mL dengan mean 11.99 µg/mL dan rentang 6,12 ? 23,26 µg/mL.Didapatkan perbedaan bermakna kadar fibrin monomer pada gestationalhypertension dan preeklampsia dengan nilai p<0,001.ABSTRACT Hypertension is a common disorder in pregnancy. Approximately 70% ofpregnant women is gestational hypertension and preeclampsia. Endothelialdysfunction in preeclampsia causes the endothelial surface of the nonthrombogenicbe thrombogenic so it can activated coagulation. Preeclampsiaincrease hypercoagulability state in normal pregnancy. Gestational hypertension isa hypertension in pregnancy who do not meet the criteria of preeclampsia. Nearlyhalf of patients with gestational hypertension develop into preeclampsia. Fibrinmonomers are used for coagulation activation marker on the prethrombotic statetherefore formed before on hypercoagulability state hiperkoagulabel than D-dimerformed after fibrinolysis. The objective of this study is to gain description offibrin monomer levels and it was a cross-sectional study 30 pregnant women withgestational hypertension and 30 pregnant women with preeclampsia. The studywas conducted in October and November 2015. Examination of fibrin monomerusing the reagent STA-Liatest and analyzer STA Compact. Mean of fibrinmonomer in gestational hypertension was 4.61 µg/mL with standard deviationwas 0.86 µg/mL. Median of fibrin monomer in preeclampsia was 10.5 µg / mLwith range was 6.12 to 23.26 µg/mL. Fibrin monomer levels found significantdifferences in gestational hypertension and preeclampsia with p <0.001.;Hypertension is a common disorder in pregnancy. Approximately 70% ofpregnant women is gestational hypertension and preeclampsia. Endothelialdysfunction in preeclampsia causes the endothelial surface of the nonthrombogenicbe thrombogenic so it can activated coagulation. Preeclampsiaincrease hypercoagulability state in normal pregnancy. Gestational hypertension isa hypertension in pregnancy who do not meet the criteria of preeclampsia. Nearlyhalf of patients with gestational hypertension develop into preeclampsia. Fibrinmonomers are used for coagulation activation marker on the prethrombotic statetherefore formed before on hypercoagulability state hiperkoagulabel than D-dimerformed after fibrinolysis. The objective of this study is to gain description offibrin monomer levels and it was a cross-sectional study 30 pregnant women withgestational hypertension and 30 pregnant women with preeclampsia. The studywas conducted in October and November 2015. Examination of fibrin monomerusing the reagent STA-Liatest and analyzer STA Compact. Mean of fibrinmonomer in gestational hypertension was 4.61 µg/mL with standard deviationwas 0.86 µg/mL. Median of fibrin monomer in preeclampsia was 10.5 µg / mLwith range was 6.12 to 23.26 µg/mL. Fibrin monomer levels found significantdifferences in gestational hypertension and preeclampsia with p <0.001.;Hypertension is a common disorder in pregnancy. Approximately 70% ofpregnant women is gestational hypertension and preeclampsia. Endothelialdysfunction in preeclampsia causes the endothelial surface of the nonthrombogenicbe thrombogenic so it can activated coagulation. Preeclampsiaincrease hypercoagulability state in normal pregnancy. Gestational hypertension isa hypertension in pregnancy who do not meet the criteria of preeclampsia. Nearlyhalf of patients with gestational hypertension develop into preeclampsia. Fibrinmonomers are used for coagulation activation marker on the prethrombotic statetherefore formed before on hypercoagulability state hiperkoagulabel than D-dimerformed after fibrinolysis. The objective of this study is to gain description offibrin monomer levels and it was a cross-sectional study 30 pregnant women withgestational hypertension and 30 pregnant women with preeclampsia. The studywas conducted in October and November 2015. Examination of fibrin monomerusing the reagent STA-Liatest and analyzer STA Compact. Mean of fibrinmonomer in gestational hypertension was 4.61 µg/mL with standard deviationwas 0.86 µg/mL. Median of fibrin monomer in preeclampsia was 10.5 µg / mLwith range was 6.12 to 23.26 µg/mL. Fibrin monomer levels found significantdifferences in gestational hypertension and preeclampsia with p <0.001.;Hypertension is a common disorder in pregnancy. Approximately 70% ofpregnant women is gestational hypertension and preeclampsia. Endothelialdysfunction in preeclampsia causes the endothelial surface of the nonthrombogenicbe thrombogenic so it can activated coagulation. Preeclampsiaincrease hypercoagulability state in normal pregnancy. Gestational hypertension isa hypertension in pregnancy who do not meet the criteria of preeclampsia. Nearlyhalf of patients with gestational hypertension develop into preeclampsia. Fibrinmonomers are used for coagulation activation marker on the prethrombotic statetherefore formed before on hypercoagulability state hiperkoagulabel than D-dimerformed after fibrinolysis. The objective of this study is to gain description offibrin monomer levels and it was a cross-sectional study 30 pregnant women withgestational hypertension and 30 pregnant women with preeclampsia. The studywas conducted in October and November 2015. Examination of fibrin monomerusing the reagent STA-Liatest and analyzer STA Compact. Mean of fibrinmonomer in gestational hypertension was 4.61 µg/mL with standard deviationwas 0.86 µg/mL. Median of fibrin monomer in preeclampsia was 10.5 µg / mLwith range was 6.12 to 23.26 µg/mL. Fibrin monomer levels found significantdifferences in gestational hypertension and preeclampsia with p <0.001.;Hypertension is a common disorder in pregnancy. Approximately 70% ofpregnant women is gestational hypertension and preeclampsia. Endothelialdysfunction in preeclampsia causes the endothelial surface of the nonthrombogenicbe thrombogenic so it can activated coagulation. Preeclampsiaincrease hypercoagulability state in normal pregnancy. Gestational hypertension isa hypertension in pregnancy who do not meet the criteria of preeclampsia. Nearlyhalf of patients with gestational hypertension develop into preeclampsia. Fibrinmonomers are used for coagulation activation marker on the prethrombotic statetherefore formed before on hypercoagulability state hiperkoagulabel than D-dimerformed after fibrinolysis. The objective of this study is to gain description offibrin monomer levels and it was a cross-sectional study 30 pregnant women withgestational hypertension and 30 pregnant women with preeclampsia. The studywas conducted in October and November 2015. Examination of fibrin monomerusing the reagent STA-Liatest and analyzer STA Compact. Mean of fibrinmonomer in gestational hypertension was 4.61 µg/mL with standard deviationwas 0.86 µg/mL. Median of fibrin monomer in preeclampsia was 10.5 µg / mLwith range was 6.12 to 23.26 µg/mL. Fibrin monomer levels found significantdifferences in gestational hypertension and preeclampsia with p <0.001. |
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No. Panggil : | SP-PDF |
Entri utama-Nama orang : | |
Entri tambahan-Nama orang : | |
Entri tambahan-Nama badan : | |
Subjek : | |
Penerbitan : | [Place of publication not identified]: Fakultas Kedokteran Universitas Indonesia, 2016 |
Program Studi : |
Bahasa : | ind |
Sumber Pengatalogan : | LibUI ind rda |
Tipe Konten : | text |
Tipe Media : | computer |
Tipe Carrier : | online resource |
Deskripsi Fisik : | xv, 44 pages : illustration + appendix |
Naskah Ringkas : | |
Lembaga Pemilik : | Universitas Indonesia |
Lokasi : | Perpustakaan UI, Lantai 3 |
No. Panggil | No. Barkod | Ketersediaan |
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SP-PDF | 16-18-707243474 | TERSEDIA |
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